Comparison of Bioelectrical Impedance Analysis (BIA)-Derived Parameters in Healthy Volunteers and Critically Ill Patients

Objective: To compare bioelectrical impedance analysis (BIA)-derived parameters in healthy volunteers and critically ill patients and to assess its prognostic value in an ICU patient cohort. Design: Retrospective, observational data analysis. Setting: Single centre, tertiary-level ICU (Ziekenhuis Netwerk Antwerpen, ZNA Stuivenberg Hospital). Patients: 101 patients and 101 healthy subjects, participants of International Fluid Academy Days. Measurements and main results: Compared to healthy volunteers, both male and female ICU patients had significantly higher values for total body water (TBW), extracellular water (ECW), extracellular fluid (ECF), plasma, and interstitial fluid volumes. The phase angle was significantly lower and the malnutrition index was significantly higher in ICU patients, regardless of gender. Non-survivors in the ICU had significantly higher extracellular water content (ECW, 50.7 ± 5.1 vs. 48.9 ± 4.3%, p = 0.047) and accordingly significantly lower intracellular water (ICW, 49.2 ± 5.1 vs. 51.1 ± 4.3%, p = 0.047). The malnutrition index was also significantly higher in non-survivors compared to survivors (0.94 ± 0.17 vs. 0.87 ± 0.16, p = 0.048), as was the capillary leak index (ECW/ICW). Conclusions: Compared to healthy volunteers, this study observed a higher malnutrition index and TBW in ICU patients with an accumulation of fluids in the extracellular compartment. ICU non-survivors showed similar results, indicating that ICU patients and a fortiori non-survivors are generally overhydrated, with increased TBW and ECW, and more undernourished, as indicated by a higher malnutrition index

Grey value contrast sensitivity of dental practitioners in function of luminance and age

Objectives: Grey value perception is important in viewing and interpreting X-ray images. It is possible that ageing decreases the number of gray values that a person can distinguish. This hypothesis was tested in a group of dental practitioners from students to experienced dentists using a 12-bit grey scale. Methods and materials: A custom-made computer software was used based on the principle of the “just noticeable difference” (JND). Observers were shown a picture of an outer square with increasing grey value in which a smaller square of different grey value popped up in changing positions. As soon as the observers could see the difference, they clicked the inner square. The grey values were shown with a 12-bit depth in batches of 400 grey value steps. 59 dentists of 3 age groups (20–24, 25–45 and 46–70 years) participated in the study. A subgroup of 20 practitioners performed a validation test with test-retest and test in reversed grey value sequence (white to black). JND was calculated and plotted against grey value using a third-order polynomial function. These curves were compared statistically. Results: Test-retest, also in reversed order did not yield different curves (p values between 0.79 and 0.97). Curves between different age groups showed significant differences, with older practitioners needing more contrast to accomplish the task. Contrast sensitivity showed an optimum in the darker third of the grey scale (values around 1200). Conclusion: Age and grey value played a significant role in grey value perception by dental practitioners.info:eu-repo/semantics/publishe

Prognostic value of bioelectrical impedance analysis for assessment of fluid overload in ICU patients: A pilot study

Background: The non-invasive analysis of body fluid composition with bio-electrical impedance analysis (BIA) provides additional information allowing for more personalised therapy to improve outcomes. The aim of this study is to assess the prognostic value of fluid overload (FO) in the first week of intensive care unit (ICU) stay. Methods: A retrospective, observational analysis of 101 ICU patients. Whole-body BIA measurements were performed, and FO was defined as a 5% increase in volume excess from baseline body weight. Results: Baseline demographic data, including severity scores, were similar in both the fluid overload-positive (FO+, n = 49) patients and in patients without fluid overload (FO-, n = 52). Patients with FO+ had significantly higher cumulative fluid balance during their ICU stay compared to those without FO (8.8 \ub1 7.0 vs. 5.5 \ub1 5.4 litres; P = 0.009), VE (9.9 \ub1 6.5 vs. 1.5 \ub1 1.5 litres; P < 0.001), total body water (63.0 \ub1 9.5 vs. 52.8 \ub1 8.1%; P < 0.001), and extracellular water (27.0 \ub1 7.3 vs. 19.6 \ub1 3.7 litres; P < 0.001). The presence of 5%, 7.5%, and 10% fluid overload was directly associated with increased ICU mortality rates. The percentage fluid overload (P = 0.039) was an independent predictor for hospital mortality. Conclusions: A higher mortality rate in ICU-patients with FO was observed. FO is an independent prognostic factor because neither APACHE-II, SOFA, nor SAPS-II significantly differed on admission between survivors and non-survivors. Further research is needed to confirm these data prospectively and to evaluate whether BIA-guided deresuscitation in the subacute phase will improve mortality rates