Theoretical approaches towards global social development

Background/Objective: The topicality of the research is stipulated by the determination of the theoretical approaches that could serve as a basis for path finding out of the global systemic crisis. Theoretical views of outstanding economists of the past toward the future of humanity and the real state of the world are of undoubted interest. The article deals with the ideas of G.V. Plekhanov, analyzes the results of their implementation in Russia in the 1990s. Possible perspectives of social development are associated with a change in the socio-economic views on the role and the place of nature in today’s context. Methods: The basic methods of studying this problem are the economic analysis, deduction, factor analysis and system-structural approach. Findings: The authors have given the analysis of the theory of economic growth stages, considered the views of Plekhanov toward the development of capitalism in Russia and the modification of the social nature of the monarchy and its consequences. To secure its future, the humankind is destined to change moral principles. Changing social consciousness depends on the level of culture and education. The theoretical approaches are determined that could be core ones in searching for ways out of the today’s global problems. Improvements/Novelty: Solving global problems of today such as nature and society, war and peace, social inequality is closely linked to changes in consumption patterns. Nature, life on the planet should be a common goal for all countries and peoples. Economy and politics should be subject to this goal. These findings are of practical value to scientists, economists, sociologists, philosophers, as well as for college teachers.peer-reviewe

Heterodyne performance and characteristics of terahertz MgB2hot electron bolometers

We have studied THz heterodyne detection in sub-micrometer MgB2 hot electron bolometer (HEB) mixers based on superconducting MgB2 films of ∼5nm (HEB-A), corresponding to a critical temperature (Tc) of 33.9 K, and ∼7nm (HEB-B), corresponding to a \u1d447\u1d450 of 38.4 K. We have measured a double sideband (DSB) receiver noise temperature of 2590 K for HEB-A and 2160 K for HEB-B at 1.6 THz and 5 K. By correcting for optical losses, both HEBs show receiver noise temperatures of ∼1600 K referenced to the front of anti-reflection (AR)-coated Si lenses. An intermediate frequency (IF) noise bandwidth of 11 GHz has been measured for both devices. The required local oscillator (LO) power is about 13 μW for both HEBs. We have also measured a DSB receiver noise temperature of 3290 K at 2.5 THz and 5 K but with an AR-coated lens optimized for 1.6 THz. Besides, we have observed a step-like structure in current voltage (IV) curves, which becomes weaker when the LO power increases and observable only in their differential resistance. Such a correlated structure appears also in the receiver output power as a function of voltage, which is likely due to electronic inhomogeneities intrinsic to the variations in the thickness of the MgB2 films. Different behavior in the IV curves around the low bias voltages, pumped with the same LO power at 1.6 and 5.3 THz, was observed for HEB-B, suggesting the presence of a high-energy σ-gap in the MgB2 film

Green and Social Investment as a Tool for Providing Water Security in Ukrainian Settlements

The article suggests a scientific base for using «green» and social bonds to solve environmental problems in water supply systems; numerous facts that encourage using social investment tools in the high-yield water sector are revealed. In particular, preconditions for intensifying economic activity in the construction field are appearing, as it is obvious that a constant threat of shelling faced by our country changes the requirements for all living conditions, and water supply systems as well. Emphasis is placed on the assumption that if the green bond market in Ukraine is implemented and developed, it will help to create a multiplier for attracting funds to implement various environmental projects and to increase guarantees for investors injecting funds in such projects. Both negative and positive factors of using social investment to modernize water supply systems in Ukraine are identified. It is concluded that it is necessary to intensify the development of the regulatory framework for «green» and social investment in order to offset the trend of debt accumulation among enterprises operating water supply systems in Ukrainian settlements, so that such enterprises could become monopolists in the market

Финансовая политика государственной поддержки отрасли микроэлектроники в России в условиях санкций

The relevance of this study is determined by the need to develop the domestic semiconductors industry in Russia, taking into account the negative effects both internal and external.The purpose of this paper is to test the hypothesis of the positive impact of the methods used by the state of financial support of domestic companies to acquire advanced technologies in a specific area in the context of a lack of funding and the significant lag of the national semiconductor industry in the world’s leading countries.The target of this study is the analysis of possible tools of state support, including subsidies and grants, and methods of their application for the creation of competitive industry of domestic semiconductor production.The key methods used in this study include the collection and processing of statistical data, their comparative analysis, as well as the elaboration of the regulatory framework on tax regulation in this sector of the economy.The main methods applied in this study are data collection and processing, comparative analysis, and the development of a regulatory framework for tax regulation in this sector of the economy. The authors analyzed the semiconductors industry in the world, including the production of microprocessors and other semiconductor components. The situation in countries such as China, USA, Japan, Europe, Taiwan, India and Russia is discussed in more detail. The main problems with semiconductor industry development in Russia have been revealed. Additionally, researchers have evaluated and outlined fields of federal budget spendings in the industry in the period of years 2022 and 2025.The scientific novelty of this paper is to identify the relationship between the measures of state tax incentives provided to the radio-electronic industry and macroeconomic indicators. Based on that authors have developed evaluation criteria of the relevance and efficiency of fiscal preferences for the analyzed industry which is considered as the result of research.It concluded that the state’s initiatives to promote the radio-electronics industry might provide Russia a chance to catch up to the world’s leading countries in this industry.Актуальность исследования определяется необходимостью развития отечественной отрасли микроэлектроники в России с учетом сложившихся негативных как внутренних, так и внешних эффектов.Целью является проверка гипотезы о положительном влиянии используемых государством методов финансовой поддержки отечественных компаний для получения прорывных технологий в конкретной области в условиях недостатка финансирования и существенного отставания национальной отрасли микроэлектроники от ведущих стран мира.Задачей данного исследования является анализ возможных инструментов государственной поддержки, включая субсидии и гранты, а также методов их применения с целью создания конкурентной отрасли производства отечественной микроэлектроники.Основные методы, используемые в данном исследовании, включают в себя сбор и обработку статистических данных, их сравнительный анализ, а также проработку нормативной базы по налоговому регулированию в данном секторе экономики. Авторы проанализировали состояние отрасли микроэлектроники в мире, включая производство микропроцессоров и других полупроводниковых компонентов. Более детально рассмотрена ситуация в таких странах, как Китай, США, Япония, Европа, Тайвань, Индия и Россия. На основе проведенного анализа выявлены основные проблемы развития отрасли микроэлектроники в России. Дана оценка масштабов и выявлены направления расходования средств федерального бюджета на развитие радиоэлектронной промышленности в период 2022–2025 гг.Научная новизна проведенного исследования заключается в выявлении взаимосвязи между предоставляемыми мерами государственного налогового стимулирования радиоэлектронной промышленности и макроэкономическими показателями.Результаты позволили авторам выработать критерии оценки востребованности и эффективности фискальных преференций для исследуемого вида деятельности.Сделан вывод, что используемые государством меры поддержки радиоэлектронной промышленности могут дать России шанс преодолеть значительное отставание в этой отрасли от ведущих стран мира

Low noise MgB₂ hot electron bolometer mixer operated at 5.3 THz and at 20 K

We have demonstrated a low noise superconducting MgB2 hot electron bolometer (HEB) mixer working at the frequency of 5.3 terahertz (THz) with 20 K operation temperature. The bolometer consists of a 7 nm thick MgB2 submicrometer bridge contacted with a spiral antenna to couple THz radiation through a high resistive Si lens, and it has a superconducting critical temperature of 38 K. By using hot/cold blackbody loads and a Mylar beam splitter all in vacuum and applying a 5.25 THz far-infrared gas laser as a local oscillator, we measured a minimal double sideband receiver noise temperature of 3960 K at the LO power of 9.5 mu W. This can be further reduced to 2920 K if a Si lens with an antireflection coating optimized at this frequency and a 3 mu m beam splitter are used. The measured intermediate frequency (IF) noise bandwidth is 9.5 GHz. The low noise, wide IF bandwidth mixers, which can be operated in a compact, low dissipation Stirling cooler, are more suitable for space applications than the existing HEB mixers. Furthermore, we likely observed a signature of the double-gap in MgB2 by comparing current-voltage curves pumped at 5.3 and 1.6 THz

High-frequency homogenization for periodic media

This article is available open access through the publisher’s website at the link below. Copyright @ 2010 The Royal Society.An asymptotic procedure based upon a two-scale approach is developed for wave propagation in a doubly periodic inhomogeneous medium with a characteristic length scale of microstructure far less than that of the macrostructure. In periodic media, there are frequencies for which standing waves, periodic with the period or double period of the cell, on the microscale emerge. These frequencies do not belong to the low-frequency range of validity covered by the classical homogenization theory, which motivates our use of the term ‘high-frequency homogenization’ when perturbing about these standing waves. The resulting long-wave equations are deduced only explicitly dependent upon the macroscale, with the microscale represented by integral quantities. These equations accurately reproduce the behaviour of the Bloch mode spectrum near the edges of the Brillouin zone, hence yielding an explicit way for homogenizing periodic media in the vicinity of ‘cell resonances’. The similarity of such model equations to high-frequency long wavelength asymptotics, for homogeneous acoustic and elastic waveguides, valid in the vicinities of thickness resonances is emphasized. Several illustrative examples are considered and show the efficacy of the developed techniques.NSERC (Canada) and the EPSRC

New concept of pathogenesis of impaired circulation in traumatic cervical spinal cord injury and its impact on disease severity: case series of four patients

Purpose: The purpose of this study is to justify a new concept of the pathogenesis of secondary changes in the cervical spinal cord, and its correlation with the depth of development of neurological disorders in spinal injury. Methods: Standard magnetic resonance imaging examination and angiography of the cervical and vertebral arteries of four patients were performed to diagnose the prevalence rate of ischemia and edema, and examine the spinal cord vasculature. Correlation of the data obtained with the neurological status was performed. Results: Collateral circulation is most apparent in the upper-cervical region, above the C4 vertebra. Following occlusion of the vertebral artery, the circulation above the C4 vertebra is performed by collaterals of the ascending cervical artery. With extensive damage to the spinal cord, the intensity of edema and ischemia can be regarded as the effect of damage to radicular medullary arteries, which are injured in the intervertebral foramen. Secondary changes of the spinal cord are most apparent by impaired circulation in the artery of cervical enlargement. Conclusions: Collateral circulation is a significant factor that limits the damage to the cervical spinal cord. Impaired circulation in the artery of cervical enlargement is significant in extension of perifocal ischemia. The appearance of early arteriovenous shunting in the region of a primary spinal cord injury (contusion focus) by angiography is pathognomonic. The data obtained open a perspective for the endovascular treatment of spinal cord injury

Uncoupling of ATP-Mediated Calcium Signaling and Dysregulated Interleukin-6 Secretion in Dendritic Cells by Nanomolar Thimerosal

Dendritic cells (DCs), a rare cell type widely distributed in the soma, are potent antigen-presenting cells that initiate primary immune responses. DCs rely on intracellular redox state and calcium (Ca(2+)) signals for proper development and function, but the relationship between these two signaling systems is unclear. Thimerosal (THI) is a mercurial used to preserve vaccines and consumer products, and is used experimentally to induce Ca(2+) release from microsomal stores. We tested adenosine triphosphate (ATP)-mediated Ca(2+) responses of DCs transiently exposed to nanomolar THI. Transcriptional and immunocytochemical analyses show that murine myeloid immature DCs (IDCs) and mature DCs (MDCs) express inositol 1,4,5-trisphosphate receptor (IP(3)R) and ryanodine receptor (RyR) Ca(2+) channels, known targets of THI. IDCs express the RyR1 isoform in a punctate distribution that is densest near plasma membranes and within dendritic processes, whereas IP(3)Rs are more generally distributed. RyR1 positively and negatively regulates purinergic signaling because ryanodine (Ry) blockade a) recruited 80% more ATP responders, b) shortened ATP-mediated Ca(2+) transients > 2-fold, and c) produced a delayed and persistent rise (≥ 2-fold) in baseline Ca(2+). THI (100 nM, 5 min) recruited more ATP responders, shortened the ATP-mediated Ca(2+) transient (≥ 1.4-fold), and produced a delayed rise (≥ 3-fold) in the Ca(2+) baseline, mimicking Ry. THI and Ry, in combination, produced additive effects leading to uncoupling of IP(3)R and RyR1 signals. THI altered ATP-mediated interleukin-6 secretion, initially enhancing the rate of cytokine secretion but suppressing cytokine secretion overall in DCs. DCs are exquisitely sensitive to THI, with one mechanism involving the uncoupling of positive and negative regulation of Ca(2+) signals contributed by RyR1

ДИАГНОСТИЧЕСКАЯ ЗНАЧИМОСТЬ ТЕСТА GENE XPERT MTB-RIF ВО ФТИЗИАТРИЧЕСКОЙ ПРАКТИКЕ

The article presents the data on the use of Gene Хpert MBT-RIF testing in 122 patients. In 69 (56.6%) patients the diagnosis of tuberculosis was confirmed, and some other non-tuberculous pulmonary diseases were verified in 53 (43.4%) patients. Efficiency of tuberculous causative agent detection by Gene Xpert was compared to routine bacteriological methods. The sensitivity of this method made 63.8%, specificity made 98.1%, prognostic value of the positive result - 97.8%, prognostic value of negative result - 67.5%. Factors associated with positive results of this method are presented.В статье представлены данные о применении теста Gene Хpert MBT-RIF у 122 больных. У 69 (56,6%) пациентов диагноз туберкулеза был подтвержден, у 53 (43,4%) - верифицированы иные, нетуберкулезные заболевания легких. Сопоставлена эффективность выявления возбудителя туберкулеза посредством теста Gene Xpert в сравнении с рутинными бактериологическими методами. Чувствительность метода составила 63,8%, специфичность - 98,1%, прогностическая ценность положительного результата - 97,8%, прогностическая ценность отрицательного результата - 67,5%. Представлены ассоциированные факторы с положительным результатом данного метода

In Vitro Biologic Activities of the Antimicrobials Triclocarban, Its Analogs, and Triclosan in Bioassay Screens: Receptor-Based Bioassay Screens

BackgroundConcerns have been raised about the biological and toxicologic effects of the antimicrobials triclocarban (TCC) and triclosan (TCS) in personal care products. Few studies have evaluated their biological activities in mammalian cells to assess their potential for adverse effects.ObjectivesIn this study, we assessed the activity of TCC, its analogs, and TCS in in vitro nuclear-receptor-responsive and calcium signaling bioassays.Materials and methodsWe determined the biological activities of the compounds in in vitro, cell-based, and nuclear-receptor-responsive bioassays for receptors for aryl hydrocarbon (AhR), estrogen (ER), androgen (AR), and ryanodine (RyR1).ResultsSome carbanilide compounds, including TCC (1-10 muM), enhanced estradiol (E(2))-dependent or testosterone-dependent activation of ER- and AR-responsive gene expression up to 2.5-fold but exhibited little or no agonistic activity alone. Some carbanilides and TCS exhibited weak agonistic and/or antagonistic activity in the AhR-responsive bioassay. TCS exhibited antagonistic activity in both ER- and AR-responsive bioassays. TCS (0.1-10 muM) significantly enhanced the binding of [(3)H]ryanodine to RyR1 and caused elevation of resting cytosolic [Ca(2+)] in primary skeletal myotubes, but carbanilides had no effect.ConclusionsCarbanilides, including TCC, enhanced hormone-dependent induction of ER- and AR-dependent gene expression but had little agonist activity, suggesting a new mechanism of action of endocrine-disrupting compounds. TCS, structurally similar to noncoplanar ortho-substituted poly-chlorinated biphenyls, exhibited weak AhR activity but interacted with RyR1 and stimulated Ca(2+) mobilization. These observations have potential implications for human and animal health. Further investigations are needed into the biological and toxicologic effects of TCC, its analogs, and TCS