Proteomic dataset of Paracentrotus lividus gonads of different sexes and at different maturation stages

We report the proteomic dataset of gonads from wild Paracentrotus lividus related to the research article entitled "Proteomic changes occurring along gonad maturation in the edible sea urchin Paracentrotus lividus" [1]. Gonads of three individuals per sex in the recovery, pre-mature, mature, and spent stages were analyzed using a shotgun proteomics approach based on filter-aided sample preparation followed by tandem mass spectrometry, protein identification carried out using Sequest-HT as the search engine within the Proteome Discoverer informatics platform, and label-free differential analysis. The dataset has been deposited in the ProteomeXchange Consortium via the PRIDE partner repository with the dataset identifier PRIDE: PXD004200

Benign thyroid nodules treatment using Percutaneous Laser Ablation (PLA) and Radiofrequency Ablation (RFA)

Purpose: To evaluate the reduction over time of benign thyroid nodules treated using percutaneous laser ablation (PLA) and radiofrequency ablation (RFA) by the same equipe. Materials and methods: Ninety patients (age 55.6\u2009\ub1\u200914.1 years) underwent ablation for benign thyroid nodule causing compression/aesthetic dissatisfaction from 2011. Fifty-nine (age 55.8\u2009\ub1\u200914.1 years) underwent RFA and 31 (age 55.2\u2009\ub1\u200914.2 years) PLA, ultrasound guided. Technical success, complications, duration of ablation and treatment, energy deployed, volumetric percentage reduction at 1, 6 and 12 months were derived. A regression model for longitudinal measurements was used with random intercept and random slope. Values are expressed as mean\u2009\ub1\u2009standard deviation or N (%). Results: Technical success was always obtained. No major complications occurred. Mean ablation time was 30.1\u2009\ub1\u200913.8 vs. 13.9\u2009\ub1\u20095.9\u2009min (p\u2009<\u2009.0001) and mean energy deployment was 5422.3\u2009\ub1\u20092484.5 J vs. 34 662.7\u2009\ub1\u200915 812.3 J in PLA vs. RFA group. Mean volume reduced from 20.3\u2009\ub1\u200916.4\u2009ml to 13.17\u2009\ub1\u200910.74\u2009ml (42%\u2009\ub1\u200917% reduction) at 1st month, 8.7\u2009\ub1\u20097.4\u2009ml (60%\u2009\ub1\u200915% reduction) at 6th month and 7.1\u2009\ub1\u20097.7\u2009ml (70%%\u2009\ub1\u200916% reduction) at 12th month, in PLA group, and from 32.7\u2009\ub1\u200919.5\u2009ml to 17.2\u2009\ub1\u200912.9\u2009ml (51%\ub115% reduction) at 1st month, 12.8\u2009\ub1\u20099.6\u2009ml (64\u2009\ub1\u200914% reduction) at 6th month and 9.9\u2009\ub1\u20099.2\u2009ml (74%\u2009\ub1\u200914% reduction) at 12th month in RFA group. No difference in time course of the relative volume reduction between the two techniques was found. Conclusions: RFA and PLA are similarly feasible, safe and effective in treating benign thyroid nodules when performed by the same equipe. RFA is faster than PLA but require significantly higher energy

Microneedles: A New Frontier in Nanomedicine Delivery

This review aims to concisely chart the development of two individual research fields, namely nanomedicines, with specific emphasis on nanoparticles (NP) and microparticles (MP), and microneedle (MN) technologies, which have, in the recent past, been exploited in combinatorial approaches for the efficient delivery of a variety of medicinal agents across the skin. This is an emerging and exciting area of pharmaceutical sciences research within the remit of transdermal drug delivery and as such will undoubtedly continue to grow with the emergence of new formulation and fabrication methodologies for particles and MN. Firstly, the fundamental aspects of skin architecture and structure are outlined, with particular reference to their influence on NP and MP penetration. Following on from this, a variety of different particles are described, as are the diverse range of MN modalities currently under development. The review concludes by highlighting some of the novel delivery systems which have been described in the literature exploiting these two approaches and directs the reader towards emerging uses for nanomedicines in combination with MN