Unveiling the Essence of Regional Humor and Local Color: A Comprehensive Analysis of Stephen Leacock's Comedic Legacy

                This paper delves into the rich tapestry of regional humor and local color in the works of Stephen Leacock, a renowned Canadian humorist. Employing a comprehensive analytical approach, the study explores Leacock's comedic legacy, dissecting the nuanced elements that contribute to the unique flavor of his humor. By unraveling the intricate layers of Leacock's writings, this research aims to illuminate the distinctive blend of wit and cultural insight that characterizes his contributions to the world of literature

A CLINICAL OBSERVATIONAL STUDY TO EVALUATE THE COMBINED EFFECT OF DADRUGHNA LEPA AND PITTAKUSTAHARA KASHAYA IN MANAGEMENT OF DADRU (TINEA)

Dadru is one among the Kushta described in the classical text books of Ayurveda which bears greater resemblance with Tinea or Ringworm Infection. It is the commonest single fungus group of infectious skin disorders found in unhygienic conditions of tropical and subtropical countries and most encountered in clinical practice. Unless properly treated they become chronic. Dadru is a disease where all the treatment modalities can be applied as per the requirement of the disease condition. Here in this study, patients diagnosed with Dadru were treated with Dadrughna Lepa externally and Pittaja Kustahara Kashaya internally for a period of 30 days and observations were recorded. Methods: 50 patients fulfilling the diagnostic and inclusion criteria were considered for this single group study of 30 days for each patient. Periodical assessment done during the course of treatment and observations recorded as per case proforma. The data collected during study were Statistical analysed and resultant overall effect of therapy is noted. Results: As a result, Out of 50 patients, highly significant results (p< 0.05) were obtained with respect to Kandu (Itching) (i.e. 75.61%), Raga (Redness)(79.61%), Daha (Burning sensation)(83.12%), Pidaka (Eruption) (84.21%), Rookshata (Dryness)(53.66%), Udgata Mandala (elevated lesion) (71.43%), Size and No. of Lesions (67.82%). Discussion: Out of 50 patients, 2 patients (4%) were getting No improvement, 4 patients (8%) observed to have Mild improvement, 16 patients (32%) were observed with Moderate improvement and 28 patients (56%) with Marked Improvement. Overall effect of the treatment observed is 75.25%

Finasteride as a model for personalized medicine

The side effects of Finasteride are currently a subject of controversy. Some studies report minor or acceptable adverse effects, which decrease after a variable period of time so that they do not necessitate terminating Finasteride administration. However, several clinical and neuro-endocrine studies show that some adverse effects persist indefinitely in the form of post-Finasteride syndrome, even after the drug cessation. This paper presents a possible explanation for these inconsistent findings. First, the study design of either informing or not informing patients prior therapy about possible adverse effects can influence the incidence and magnitude of reported adverse effects. Second, structural and information dichotomies of the brain generate four distinct neuronal networks, which are activated through specific cerebral neuromodulators and that are able to support four distinct minds within an individual body. As a conclusion, the “mind psychophysiology” and the corresponding mental impairments differ across individuals, such that not only the prediction of adverse effects should be addressed from a more individualized medical perspective, but also the therapeutic strategies could be tailored to the four distinct mental profiles described. It is a personalized approach that would be applicable to several interrelated domains of neuroscience, like psychology, psychiatry and sexuality. Finally, this perspective may represent a starting point for a more individualized understanding of mental events, perhaps even a step forward in the understanding of the mind-body problem

Anakyzing the performance of Active Queue Management Algorithms

Congestion is an important issue which researchers focus on in the Transmission Control Protocol (TCP) network environment. To keep the stability of the whole network, congestion control algorithms have been extensively studied. Queue management method employed by the routers is one of the important issues in the congestion control study. Active queue management (AQM) has been proposed as a router-based mechanism for early detection of congestion inside the network. In this paper we analyzed several active queue management algorithms with respect to their abilities of maintaining high resource utilization, identifying and restricting disproportionate bandwidth usage, and their deployment complexity. We compare the performance of FRED, BLUE, SFB, and CHOKe based on simulation results, using RED and Drop Tail as the evaluation baseline. The characteristics of different algorithms are also discussed and compared. Simulation is done by using Network Simulator(NS2) and the graphs are drawn using X- graph.Comment: 19 Pages, IJCNC Journal 201

On generalized sarmanov bivariate distributions

A class of bivariate distributions which generalizes the Sarmanov class is introduced. This class possesses a simple analytical form and desirable dependence properties. The admissible range for association parameter for given bivariate distributions are derived and the range for correlation coefficients are also presented.Publisher's Versio

Androgenic alopecia; the risk–benefit ratio of Finasteride

Finasteride is currently approved and largely used as a therapeutic option for androgenetic alopecia. Apparently a safe drug and effective at the onset of its application, several concerns have since appeared over the years regarding the frequency and magnitude of finasteride adverse effects, which in some cases appear irreversible even after drug termination. This paper discusses the use of finasteride for androgenic alopecia from two distinct perspectives. On the one hand, androgenic alopecia is a condition that especially affects a person’s self-image and esteem, aspects that are subjectively-constructed and thus relative and changeable. On the other hand, this condition involves a multifactorial etiology, with androgens being only partly responsible. Because androgens have important and unique physiological roles within the body, any procedure that results in androgenic suppression should be advised with caution. Furthermore, adverse effects induced by finasteride are neither fully documented nor easily treated. Finally, as alternative therapeutic approaches (such as topical finasteride) become available, the oral administration of finasteride for androgenic alopecia should, in our opinion, be reevaluated. Due to such concerns, a detailed and informed discussion should take place with patients considering therapy with finasteride for androgenic alopecia

Strong Forms of b-Continuous Multifunctions

In this paper we have introduced strong forms of b-continuous multifunctions namely b#-multicontinuity and *b-multicontinuity and studied their properties and characterizations. Also investigate the relationship with other type of functions with suitable examples

Pre clinical and clinical study on Swasa Kasam and the drug of choice is Thuthuvalayathy Chooranam

The aim of the study was to evaluate the therapeutic efficacy of the drug Thuthuvalayathy chooranam (internal medicine) in Swasa kasam. • Before initiating the clinical trial, approval was got from the Institutional Animal Ethical Committee (1248/ac/09/CPCSEA/4/04/2011 – 20/12/2011) and Institutional Ethical Committee (NIS/IEC/2011/3/04 – 24/12/2011) for conducting the pre clinical studies and clinical studies respectively by submitting the well defined protocol and proforma. • The raw drugs were authenticated by the concerned department and the trial drug was prepared by the investigator in the Gunapadam lab of National Institute of Siddha as per the Standard Operating Procedure mentioned in the protocol. • The medicine was then subjected to pre clinical toxicity studies (Acute and sub acute toxicity studies) as per the protocol and the safety of the drug was ensured. • From the Acute oral toxicity study, the trial drug was found to be safe even at higher dose level of 0.027gm/kg/bw. • From the sub acute toxicity study the trial drug at the dose of 0.27gm/kg/bw (10X) did not exhibit any mortality in rats. • The qualitative and quantitative bio chemical studies were done at the bio chemistry lab of National Institute of Siddha and IIT Chennai respectively. • For the clinical study, 40 cases were selected based on the inclusion and exclusion criteria. Out of this, 30 cases were treated in OPD and 10 cases were treated in IPD of Ayothidoss pandithar hospital of NIS, Chennai. • A day before starting the trial drug treatment, purgation was given to correct the elevated mukkutram. • The clinical trial was conducted in 40 patients of Swasa kasam with the trial drug thuthuvalayathy chooranam(internal medicine) at the dose of 1.5gm twice a day with adjuvant of honey .During the study period, there were no adverse reactions. • The trial drugs were found to play the major role to correct the deranged three humours, thereby correcting Pranan, Abanan, Udhanan, Kirugaran, Devathathan Vayus, Pitham such as Anal Pitham and the vitiated kabam is restored to the normal. • Blood and urine Investigations were carried out before and after treatment and data were recorded in the proforma. • Radiological investigations (Chest X-ray PA view) and ECG were also done before treatment. • Clinical assessments Progress were done once in 7 days for OPD patients and daily for IPD patients. • As per objective parameters (PEFR) Out of 40 cases, 72.5% of cases had clinically good improvement, 22.5% of cases had clinically moderate improvement and 5% of cases had clinically mild improvement. • Out of 40 cases, Clinical results were found to be Good in 87.5% of cases, Moderate results were found in 10% of cases and Mild results were found in 2.5% of cases Statistical analysis: PEFR, Esinophil,ESR for ½ hr and 1 hrs before treatment and after treatment is statistically significant (p<0.0001). CONCLUSION 1. Toxicity study reveals that the trial drugs is safe even in higher dosage of thuthuvalathy chooranam – 0.27 gm/animal in albino rats as per WHO guideline 1993. 2. The results of the clinical trial indicate that the trial drugs are clinically effective. No adverse effects were reported during the course of treatment. 3. The method of preparation is easy and the cost is comparatively economical. 4. Clinical results were found to be Good in 87.5% of cases, moderate results were found in 10% of cases and mild results were found in 2.5% of cases. Because of the encouraging results clinically, the study may be undertaken with same medicine in a large number of cases and it may throw new lights for the treatment of Swasa kasam

Perinatal outcome of meconium stained amniotic fluid in pregnancy beyond 37 weeks

Background: To identify the frequency of meconium aspiration syndrome among the total births who suffered from meconium staining of amniotic fluid, to find out risk factors during pregnancy, therapies and various complications associated with this condition and their effects on perinatal outcome.Methods: This was a retrospective study of 252 antenatal patients delivered at Department of DNB-OBG District hospital Bellary during the year January 2019 to December 2019 with gestational age between 37-40 weeks with singleton pregnancies and cephalic presentation were included in the study.Results: The Caesarean section rate for fetal distress was 96.6% in patients with meconium stained amniotic fluid (MSAF). Meconium aspiration syndrome (MAS) was found in3.93% babies. APGAR score at 1 minute <7 was found in 25 cases (9.84%).Conclusions: Meconium stained amniotic fluid is associated with increased need for neonatal resuscitation, increased risk of birth asphyxia, meconium aspiration syndrome, hospital admission and mortality. So identification of pregnant woman at risk of passage of meconium during labour would allow intensive fetal surveillance and early intervention which might lead to reduction in neonatal adverse outcome

Fetal and maternal outcome in oligohydramnios pregnancy (37-40 weeks)

Background: This study is conducted to see the effects of oligohydramnios on both mother and fetus.Methods: 237 antenatal patients delivered at Department of DNB-OBG District hospital Bellari during January 2018 to December 2018 with gestational age between 37-40wks with AFI2.5 kg birth weight about 144 (60.75%) of cases.  New born with APGAR <7 @ 1 min seen in 36 cases (15.15%). Meconeum stained liquor seen in about 70 cases (29.5%).Conclusions: Oligohydramnios has significant correlation with increased Caesarean section for fetal distress. Oligohydramnios is associated with high rate of pregnancy complication and increased rate of NICU admission. Oligohydramnios is a frequent occurrence demanding careful evaluation, intensive fetal surveillance and proper antepartum and intrapartum care