165,784 research outputs found
A survey of epistemology and its implications on an organisational information and knowledge management model
This is a theoretical paper which aims to integrate various epistemologies from the philosophical, knowledge management, cognitive science, and educational perspectives. From a survey of knowledge-related literature, we have collated diverse views of knowledge. This is followed by categorising as well as ascribing attributes to the different types of knowledge. We have developed a novel Organisational Information and Knowledge Management Model which seeks to clarify the distinctions between information and knowledge by introducing a novel information and knowledge conversions; followed by providing mechanisms for individual knowledge creation and information sharing within an organisation
The PULSE Vision & Change Rubrics,version 1.0: A valid and equitable tool to measure transformation of life sciences departments at all institution types
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OntoEng: A design method for ontology engineering in information systems
This paper addresses the design problem relating to ontology engineering in the discipline of information systems. Ontology engineering is a realm that covers issues related to ontology development and use throughout its life span. Nowadays, ontology as a new innovation promises to improve the design, semantic integration, and utilization of information systems. Ontologies are the backbone of knowledge-based systems. In addition, they establish sharable and reusable common understanding of specific domains amongst people, information systems, and software agents. Notwithstanding, the ontology engineering literature does not provide adequate guidance on how to build, evaluate, and maintain ontologies. On the basis of the
gathered experience during the development of V4 Telecoms Business Model Ontology as well as the conducted integration of the related literature from the design science paradigm, this paper introduces OntoEng and its application as a novel systematic design
method for ontology engineering
Placental Morphology of Pregnant Iraqi Women with Rheumatic Heart Disease
Background: Placental morphology and cellular arrangement can be altered in maternal diseases. Rheumatic heart disease (RHD) is a chronic heart condition that can lead to death in pregnant women. The aim of this study is to determine the histological changes of the placenta in pregnant women suffering from RHD. Methods: Placentae were collected from 10 healthy pregnant women, and 31 pregnant women with heart conditions (26 with RHD and 5 with NRHD) who had been admitted to the Baghdad Teaching Hospital. Placental tissues were fixed in 10% formal-saline and were processed for light microscopy. Measurements including the placental weight and diameter of the chorionic villi capillaries were recorded. Results: The results indicate that there are many histological changes in pregnant women with RHD such as hyalinisation, fibrosis of the chorionic villi, proliferation of trophoblastic cells, and thickening of its membrane. Additionally, expectant mothers with RHD experience a reduction in capillary diameter and thickening of the capillary walls, and decreased size and weight of their placenta when compared with the control. Conclusions: Heart diseases, especially RHD, are associated with developmental damage of the placenta in pregnant women by injuring the endothelial cells of the placentas capillaries
Moving forward with actionable therapeutic targets and opportunities in endometrial cancer: NCI clinical trials planning meeting report on identifying key genes and molecular pathways for targeted endometrial cancer trials
Serum resistin is associated with C-reactive protein and LDL- cholesterol in type 2 diabetes and coronary artery disease in a Saudi population
Aims
Resistin is an adipocyte-derived factor implicated in obesity-associated type 2 diabetes (T2DM). This study examines the association between human serum resistin, T2DM and coronary heart disease.
Methods
One hundred and fourteen Saudi Arabian patients (male: female ratio 46:68; age 51.4 (mean ± SD)11.7 years; median and range: 45.59 (11.7) years and BMI: 27.1 (mean ± SD) 8.1 Kgm2 median and range: 30.3 (6.3) were studied. Serum resistin and C-reactive protein (CRP), a marker of inflammation CRP levels, were measured in all subjects. (35 patients had type 2 diabetes mellitus (T2DM); 22 patients had coronary heart disease (CHD).
Results
Serum resistin levels were 1.2-fold higher in type 2 diabetes and 1.3-fold higher in CHD than in controls (p = 0.01). In addition, CRP was significantly increased in both T2DM and CHD patients (p = 0.007 and p = 0.002 respectively). The use of regression analysis also determined that serum resistin correlated with CRP levels (p = 0.04, R2 0.045).
Conclusion
The findings from this study further implicate resistin as a circulating protein associated with T2DM and CHD. In addition this study also demonstrates an association between resistin and CRP, a marker of inflammation in type 2 diabetic patients
JPEG steganography: A performance evaluation of quantization tables
The two most important aspects of any image based steganographic system are the imperceptibility and the capacity of the stego image. This paper evaluates the performance and efficiency of using optimized quantization tables instead of default JPEG tables within JPEG steganography. We found that using optimized tables significantly improves the quality of stego-images. Moreover, we used this optimization strategy to generate a 16x16 quantization table to be used instead of that suggested. The quality of stego-images was greatly improved when these optimized tables were used. This led us to suggest a new hybrid steganographic method in order to increase the embedding capacity. This new method is based on both and Jpeg-Jsteg methods. In this method, for each 16x16 quantized DCT block, the least two significant bits (2-LSBs) of each middle frequency coefficient are modified to embed two secret bits. Additionally, the Jpeg-Jsteg embedding technique is used for the low frequency DCT coefficients without modifying the DC coefficient. Our experimental results show that the proposed approach can provide a higher information-hiding capacity than the other methods tested. Furthermore, the quality of the produced stego-images is better than that of other methods which use the default tables
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