25-Hydroxy vitamin d levels and endothelial vasodilator function in normotensive women

Introduction: Vitamin D was shown to be related to endothelial function and bloodpressure. Reactive hyperaemia index (RHI) measurement by pulse arterial tonometryis a new method to evaluate vasodilator function of endothelium. We aimedto evaluate the relationship between vitamin D levels and RHI in women.Material and methods: We enrolled 56 normotensive, nonsmoker, normolipidemicand normoglycemic women, (23 with 25-OH-vita min D levels > 20 µg/l,and 33 with values lower than 20 µg/l). The cardiologist who was blind for vitaminD results executed measurements by pulse arterial tonometry. The measurementwas performed on the lying patient with pre- and post-occlusion measurementsof RHI by digital sensors placed on each index finger, by 5 minintervals. Pulse amplitudes were recorded, pre-occlusion and post-occlusionratio was compared by the software of device. Stepwise linear regression andmultiple regression analyses were performed to evaluate predictors of endothelialfunction.Results: The low vitamin D group had a lower RHI value than the normal vitaminD group (p = 0.042). In regression analysis, positive predictors of RHI wereserum 25-OHD (ß = 0.401; 95% CI 0.010-0.042, p = 0.002), serum albumin(ß = 0.315; 95% CI 0.286-2.350, p = 0.013), and, inversely, serum calcium(ß = –0.247; 95% CI (–1.347)-(–0.010), p = 0.047).Conclusions: Serum 25-hydroxy vitamin D was significantly related to endothelialfunctions measured as RHI, even in healthy non-smoker women

Theory of mind deficit in bipolar disorder major depressive episode

Bu çalışmanın amacı, Bipolar Bozukluk (BB) major depresyon döneminde olan hastalarda sağlıklı kontrollere göre akıl teorisi yetilerinde bozukluk olup olmadığı ve akıl teorisi defisitinin cinsiyet, yaş, eğitim düzeyi, depresyon şiddeti, hastalık süresi, atak sayısı, hastaneye yatış öyküsü, özkıyım girişimi öyküsü, anksiyete gibi klinik değişkenler ve sosyal uyum ile ilişkisini araştırmaktır. Çalışmaya BB major depresyon döneminde olan 50 hasta ve 50 sağlıklı kontrol grubu dahil edilmiştir. Demografik bilgiler ve hastalık öyküsü alınmış, Beck Depresyon Envanteri (BDE), Beck Anksiyete Envanteri (BAE), İma Testi, Gözler Testi, Sosyal Uyum ve Kendini Değerlendirme Ölçeği (SUKDÖ), Muhakeme Becerisi (WAIS-R) testleri uygulanmıştır. BB major depresyon döneminde akıl teorisi defisitinin depresyon şiddeti, cinsiyet, eğitim düzeyi, manik atak sayısı, hastaneye yatış öyküsü, sosyal işlevsellik düzeyi ve anksiyeteden bağımsız biçimde var olduğu bulunmuştur. Akıl teorisi defisitinin, diğer özellikleri ne olursa olsun BB major depresyon döneminde olan bireyi normallerden ayıran önemli bir etmen olduğu tespit edilmiştir. Sonuç olarak akıl teorisi defisitinin BB major depresyon döneminin temel patolojisinde yer aldığı ve patolojinin varlığını (belki de ortaya çıkışını) diğer özelliklerinden bağımsız biçimde etkilediği düşünülmüştür.The aim of this study is to Access the theory of mind deficits in the patients with bipolar disorder major depressive episode compared to healty controls. Fifty patients with bipolar disorder major depressive episode and 50 healty controls were included in the study. Beck depression inventory (BDI) , Beck anxiety inventory Envanteri (BAI), Reading the Mind in the Eyes test, The Hinting Task, Social Adaptation Self-evaluation Scale (SASS) and Adult Intelligence Scale-Revised (WAIS-R) tests were used as assessment tools. The theory of mind deficit in bipolar disorder major depressive episode was found to be independent from gender, age, education, level of social functioning, severity of depression, numbers of manic episode, hospitalisation history and anxiety. According to our findings, we may suggest that the theory of mind deficit may play a defining role in the pathophysiology of bipolar disorder major depressive episode independent of sociodemographic charecteristics of the patients and clinical charecteristics of major depressio

Further Guaianolides from Chrysophthalmum montanum

Five new guaiane type sesquiterpene lactones; 6 beta-hydroxy-guai-9(10)-en-12,8 beta-olide-4 beta-O-beta-glucopyranoside (1), 6 beta-acetoxy-guai-9(10)-en-12,8 beta-olide-4 beta-O-beta-glucopyranoside (2), 5 alpha,10 beta-dihydroxy-guai-1(2)-en-12,8 beta-olide (3), 4 beta-hydroxy-guai-1(2)-en-12,8 beta-olide-10 beta-O-beta-glucopyranoside (4a), 1 alpha,4 alpha,10 beta-trihydroxy-guaian-12,8 beta-olide (5) were identified in the repeated examination of the aerial parts of the Chrysophthalmum montanum (DC) Boiss. The structures of the isolated compounds were elucidated by extensive 1D- and 2D-NMR spectroscopic analyses in combination with HRESIMS experiments

Biflavonoids from Fumana procumbens (DUNAL) GREN GODR.

The first phytochemical investigation on the aerial parts of Fumana procumbens (Dunal) Gren. & Godr. led to the isolation and identification of six compounds, including two biflavonoids, i.e. dihydrodaphnodorin B (1) and daphnodorin B (2); three flavonoids, i.e. quercitrin (3), myricitrin (4), and quercetin (5); and a flavan derivative, i.e. epigallocatechin (6). The structures of the compounds were elucidated by extensive 1D- and 2D-NMR spectroscopic analysis in combination with MS experiments. This is the first report on the isolation of biflavonoids from the genus Fumana and from the family Cistaceae. (C) 2017 Elsevier Ltd. All rights reserved

Chemical constituents of Stenotaenia macrocarpa Freyn & Sint. (Apiaceae)

© 2021 Elsevier LtdPhytochemical investigation of Stenotaenia macrocarpa Freyn & Sint. (Apiaceae) led to the isolation of ten known compounds: eight flavonoids (1–8) and two furanocoumarins (9–10). The chemical structures of the compounds were elucidated based on 1D and 2D NMR and MS spectra, as well as comparison with the relevant literature data. To the best of our knowledge, this is the first detailed phytochemical study about Stenotaenia macrocarpa and the first report on the isolation of all the compounds from the genus Stenotaenia, and manghaslin (2) and its methoxylated derivative typhaneoside (3) from Apiaceae. The chemotaxonomic significance of isolates was also discussed

Chemical Constituents of Pulicaria armena Boiss. & Kotschy ex Boiss. (Asteraceae); an Endemic Turkish Species

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Cytotoxic Activity-Guided Isolation Studies on Fumana procumbens (Dunal) Gren. & Godr.

Among the plant secondary metabolites much attention has been given to naturally occurring phenolic compounds as attractive candidates for cancer treatment and prevention. Fumana procumbens (Dunal) Gren. & Godr (Cistaceae) is a perennial herb, distributed in inner and southwest Anatolia, Turkey. F. procumbens was shown to be rich in phenolic constituents especially flavonoids and biflavonoids which are known for their antioxidant and anticarcinogenic effects. Thus, this study aims to investigate the anticancer activity of F. procumbens extracts, fractions and pure compounds by MTT test against HeLa, MCF-7, and A549 as well as BEAS-2B cell lines for determining selectivity. Bioactivity-guided phytochemical investigation on Fumana procumbens (Dunal) Gren. & Godr. led to the isolation and identification of three biflavonoids: genkwanol A, dihydrodaphnodorin B and stelleranol. The structures were elucidated by extensive 1D- and 2D-NMR spectroscopic analysis in combination with MS experiments. This is the first report on the isolation of genkwanol A and stelleranol from the genus Fumana and from the family Cistaceae. As a result, no individual cytotoxic activity was obtained for biflavonoid compounds. However, the former fractions FrC and FrD as well as MeOH and n-BuOH extracts exerted moderate and significant cytotoxic activity which suggested a possible synergistic effect