Benign and Malignant Neoplasms Affecting Periodontal Tissues: A Retrospective Study

Introduction: Oral neoplasms are the second most common oral lesions after reactive proliferative lesions. The aim of this study is to determine the distribution of the oral neoplasms by gender and age, and briefly discussed the clinical manifestations, diagnosis, and treatments of these lesions. Materials and Methods: To collect the study material, a pathological retrospective archive analysis has been performed and 61 oral neoplasm cases were determined in a total of 423 samples. 61 biopsies and clinical data of patients were studied and classified based on their histopathologic diagnosis, age, gender, and frequency. Results: In our study, a total of 61 neoplastic lesions were examined, and the mean age was 45.5 ±18.2. The most common lesion in the oral neoplastic lesion is leukoplakia (n=15, 24.59%). This is followed by squamous cell carcinoma (SCC) (n =13, 21.31%) and squamous papilloma (n =11, 18.03%). The rest are gingival granular cell tumor, hemangioma, odontoma, lipoma, mucosal nevus, myxoma, ameloblastoma, leukemia, melanoma, lymphoma, and osteosarcoma. Conclusion: This study provided important data on the frequency and histological distribution of oral benign and malign neoplasms. This study also highlights the diagnosis, and management of these oral neoplasms for the dentists

The effect of periodontal treatment on the severity of disease on patients having desquamative gingivitis related with pemphigus vulgaris (Case Series)

Pemfigus Vulgaris (PV) deri ve mükoz membranlar n otoimmün vezikülobülloz bir hastaldr. Çou vakada, oral mukoza etkilenir ve oral lezyonlar hastaln ilk belirtisi olabilir. Baz hastalarda, deri tutulumu oral lezyonlar takip edebilir. Etiyoloji ve patogenez tam olarak net deildir. Zaman nda tehis ve oral lezyonlarn tedavisi kritik önem arz eder. Ancak PV’in erken oral lezyonlarnn tehisi zordur, çünkü balangç oral lezyonlar spesifik deildir, yüzeysel erozyon ve ülserasyonlar seklinde aça çkar ve nadiren bül oluumu gösterirler. Oral lezyonlar dietini de içeren herhangi bir yerde oluabilir, ancak; PV ile birlikte görülen deskuamatif gingivitisin skl pemfigoid veya liken planus gibi dier mukokütanöz durumlara göre daha nadirdir. Tehis; biyopsinin histolojik olarak incelenmesi ve immünohistokimyasal boyama ile dorulanr. Tedavi; kortikosteroidler ve genelde azatioprin ve dier ajanlarla sistemik immünsüpresyon ile yaplmaktadr, ancak potansiyel olarak daha az yan etkiye sahip yeni tedaviler umut vericidir. Bu makale PV tehisi konulmu 3 hastann klinik özelliklerini ve tedavilerini göstermektedir.Pemphigus Vulgaris (PV) is an autoimmune vesiculobullous disease of the skin and mucous membranes. In most cases oral mucosa is frequently affected, and oral lesions may be the first sign of the disease. In some patients, oral lesions may also be followed by skin involvement. The etiology and pathogenesis are not completely clear. Timely recognition and treatment of oral lesions is critical. Early oral lesions of PV are difficult to diagnose, since the initial oral lesions may be relatively nonspecific, manifesting as superficial erosions or ulcerations, and rarely presenting with the formation of intact bullae. Oral lesions may occur anywhere including gingiva; however, desquamative gingivitis is less common with PV than other mucocutaneous conditions such as pemphigoid or lichen planus. The diagnosis is confirmed by biopsy with histological examination and immunostaining. Treatment is done by systemic immunosuppression with corticosteroids, usually azathioprine or other agents, but newer treatments with potentially fewer adverse effects look promising. This paper describes clinical features and treatment of 3patients who is diagnosed as having PV

Impact of Non-Surgical Periodontal Treatment of Generalized Chronic Periodontitis on Quality of Life

Aim: In recent years, after treatments variety of measurement scales are used to record the extent and impact of the treatment on quality of patient’s life. Among these scales, Oral Health Impact Profile (OHIP-49) and a shorter version of that OHIP-14 are the most comprehensive, accessible and common ones. Our aim was to evaluate the effect of non-surgical periodontal therapy on quality of generalized chronic periodontitis patients’ life by using the Turkish version of the OHIP-14 scale (OHIP-14-TR). Method: 58 patients (37 men and 21 women) diagnosed with generalized chronic periodontitis and requiring non-surgical periodontal therapy were recruited in this study. All patients were asked to fill in a form containing demographic, socio-economic information, reason of dental visit and oral hygiene habits. Clinical periodontal parameters (Plaque index (PI), gingival index (GI), probing pocket depth (PPD), clinical attachment loss (CAL), and bleeding on probing (BOP)) were recorded at baseline, and one month after treatment. Non-surgical periodontal treatment containing scaling and root planning was performed during one week in two seperate sessions. OHIP-14-TR questionnaires have been filled out before and after treatment. Results: There were significant decreases in all periodontal parameters and OHIP-14-TR one month after non-surgical periodontal treatment (p0.05). Significant positive correlation was found between physical pain, and BOP and PPD. After periodontal treatment, BOP, PPD, and physical pain decreased. Conclusion: According the results of this study, it was revealed that non-surgical periodontal treatment was effective in improving the quality of life of patients

Influence of periodontal inflammation on tryptophan-kynurenine metabolism: A cross-sectional study

Objectives Kynurenine pathway (KP) is the primary way of degrading tryptophan (TRP) and generates several bioactive metabolites (such as kynurenine (KYN), kynurenic acid (KYNA), 3-hydroxykynurenine (3OHKYN)) to regulate biological processes that include host-microbiome signaling and immune cell response. This study is aimed to determine the relationship between periodontal inflammation and tryptophan-kynurenine metabolism and identify their association with periodontal clinical parameters. Materials and methods Saliva and serum samples were collected from 20 stage III, grade B generalized periodontitis patients, and 20 periodontally healthy control individuals. Samples were analyzed for IL-6, KYN, TRP, KYN/TRP ratio, KYNA, 3OHKYN, picolinic acid (PA), and quinolinic acid (QA) by liquid chromatography-mass spectrometry. Clinical periodontal parameters (plaque index (PI), probing pocket depth (PPD), gingival recession (GR), clinical attachment loss (CAL), and bleeding on probing (BOP)) were recorded. Results Clinical parameters were significantly higher in the periodontitis group (p < 0.001). Salivary IL-6, TRP, KYN, KYNA, PA, and QA levels were significantly higher and KYN/TRP ratio was significantly lower in periodontitis group than control group (p < 0.05). Serum KYN, KYN/TRP ratio and PA levels were significantly higher in periodontitis group than control group (p < 0.05). PPD, BOP, PI, and CAL had significantly positive correlations with salivary IL-6, TRP, PA, QA, and serum KYN and significantly negative correlations with salivary KYN/TRP ratio. Conclusions Our results suggest that periodontal inflammation plays a role in local and systemic tryptophan-kynurenine metabolism.Ankara University Department of Periodontology ; Istanbul Medipol University Department of Periodontolog

Evaluation of Lipid Peroxidation and Oxidative DNA Damage in Patients With Periodontitis and Hyperlipidemia

Background: The purpose of this study is to determine the serum levels of malondialdehyde (MDA), as a lipid peroxidation marker, and 8-hydroxydeoxyguanosine (8-OHdG), as an oxidative DNA damage marker, in patients with chronic periodontitis (CP) and hyperlipidemia

Serum Lp-PLA2: as a novel viewpoint in periodontal treatment of hyperlipidaemics

Background/aim: To evaluate the effects of periodontal treatment on serum lipoprotein-associated phospholipase A2 (Lp-PLA2) and C-reactive protein (CRP) levels in hyperlipidaemic patients with periodontitis

Gingival crevicular fluid tissue/blood vessel-type plasminogen activator and plasminogen activator inhibitor-2 levels in patients with rheumatoid arthritis: Effects of nonsurgical periodontal therapy

WOS: 000399955500030PubMed ID: 27781272Background and ObjectiveThe aim of this study was to evaluate the effect of nonsurgical periodontal therapy on clinical parameters and gingival crevicular fluid levels of tissue/blood vessel-type plasminogen activator (t-PA) and plasminogen activator inhibitor-2 (PAI-2) in patients with periodontitis, with or without rheumatoid arthritis (RA). Material and MethodsFifteen patients with RA and chronic periodontitis (RA-P), 15 systemically healthy patients with chronic periodontitis (H-P) and 15 periodontally and systemically healthy volunteers (C) were included in the study. Plaque index, gingival index, probing pocket depth, clinical attachment level, bleeding on probing, gingival crevicular fluid t-PA and PAI-2 levels, erythrocyte sedimentation rate, serum C-reactive protein and disease activity score were evaluated at baseline and 3 mo after mechanical nonsurgical periodontal therapy. ResultsAll periodontal clinical parameters were significantly higher in the RA-P and H-P groups compared with the C group (p < 0.001) and decreased significantly after treatment (p < 0.001). Pretreatment t-PA levels were highest in the RA-P group and significantly decreased post-treatment (p = 0.047). Pre- and post-treatment PAI-2 levels were significantly lower in controls compared with both periodontitis groups (p < 0.05). Gingival crevicular fluid volume and the levels of t-PA and PAI-2 were significantly correlated. ConclusionIn patients with periodontitis and RA, nonsurgical periodontal therapy reduced the pretreatment gingival crevicular fluid t-PA levels, which were significantly correlated with gingival crevicular fluid PAI-2 levels. The significantly higher t-PA and PAI-2 gingival crevicular fluid levels in periodontal patients, regardless of systemic status, suggest that the plasminogen activating system plays a role in the disease process of periodontitis.Ankara University Scientific Research Projects Office, Ankara, Turkey [08B3334005]This study was supported by the Ankara University Scientific Research Projects Office, Ankara, Turkey (08B3334005). The authors declare that they have no conflicts of interest