Successful Treatment of Essential Palatal Tremor Lasting Over a Long Term with a Rare Application of Botulinum Toxin in a Child

 AbstractHow to Cite This Article: Eryılmaz A, Başal Y, Günel C, Ozkul A, Tosun A. Successful Treatment of Essential Palatal Tremor LastingOver a Long Term with a Rare Application of Botulinum Toxin in a Child. Iran J Child Neurol. Autumn 2015;9(4): 75-77.AbstractObjectiveAttention deficit hyperactivity disorder (ADHD) is one of the most prevalent mental health disorders. In recent years, the impacts of various micronutrients on ADHD have been studied. However, vitamin D has received much less attention. This study was aimed at evaluating the association and level ofserum vitamin D in children with ADHD.Materials & MethodsThis case-control study was carried out, in 2012, on 6 to 12 yr-old children. Thirty-seven were children with ADHD in the cases group and another 37 healthy children were in the control group. Venous blood sample was drawn from each child to measure the serum level of vitamin D. Other variables were compared as well.ResultsThe mean serum vitamin D level of children with ADHD (19.11±10.10 ng/ml) was significantly lower than that of the control group (28.67±13.76 ng/ml) (P<0.001).ConclusionDeficiency of vitamin D has been proved in various psychiatric diseases. This study evidenced a significantly low level of serum vitamin D in children with ADHD. This suggests the need for regularly monitoring of serum vitamin D levels and treatment of patients with vitamin D deficiencies

Electrical and structural characterization of metallic superconductor MgB2

Thesis (Master)--Izmir Institute of Technology, Physics, Izmir, 2003Includes bibliographical references (leaves: 66-72)Text in English; Abstract: Turkish and Englishviii, 72 leavesThe brittleness of recently discovered superconductor MgB2 requires novel technique to prepare them as a superconducting wire. In this study, the metal matrix composites consisting of Mg and MgB2 were fabricated by uniaxial hot pressing with a pressure application of 0.5 GPa. While some of the composite pellets was exposed to a heat treatment at 400 0C, the other samples prepared by a heat treatment at 500 0C. One of the samples in each group was a pure pellet of commercially available powders and the others include excess Mg with 5wt %, 10wt %, 15wt % and 20wt % of the MgB2 powders in the pure pellets. X-ray results illustrate that the initial excess Mg consitutient is still present in the final metal matrix composite in unreacted form, which is what we wanted. Microstructural studies performed by SEM and EDX indicate the possible presence of secondary phases like MgB4, MgB6 and MgO in very small amounts. While the MgB4 and MgB6 probably originated from the initial commercial MgB2 powder, the concentration of MgO might be increased with the heat treatment. Microstructural studies also point out that all the composites exhibited a porous structure with no significant amount of secondary phases. The temperature dependence of resistivity was measured for each sample with an application of 1 mA, 5 mA, 10 mA, 50 mA and 100 mA by four-point measurement technique. The midpoint critical temperatures at 10 mA were found in a range between 22.67 and 32.50 different sample preparation conditions. Present data imply a possible improvement in superconducting transition temperature of sample annealed at 500 °C with increasing Mg concentration up to some value between 15% and 20%, and an increase in critical current relative to samples annealed at 400 °C. For the samples prepared with lower heat treatment, there is an improvement in superconducting critical temperature up to an excess Mg concentration around 10% weight of the constituted MgB2 powder

Electrical and microstructural properties of superconducting MgB 2/Mg composites

MgB2/Mg composites were prepared to improve mechanical properties of brittle superconducting MgB2. MgB2 and Mg powders were mixed at different weight ratios and uniaxially pressed in a cylindrical dye at 0.5 GPa and at various temperatures for two hours to prepare MgB2/Mg composites. X-ray diffraction, SEM and EDX were used for phase identification and microstructural characterization. In addition to the main MgB2 and Mg phases, the microstructural studies have indicated the presence of a minor amounts of second phases, namely MgO and B-rich compounds. The surface morphology, grain size and porosity ratio of the samples prepared under various temperatures were also investigated. The resistivity measurements were performed in the range of room temperature to 15 K. The effect of excess Mg and secondary phases on critical temperature of MgB2/Mg composites were studied.TÜBİTAK project number TBAG-203

Inhibitory Effect of Pycnogenol® on Airway Inflammation in Ovalbumin-Induced Allergic Rhinitis

Background: The supplement Pycnogenol® (PYC) has been used for the treatment of several chronic diseases including allergic rhinitis (AR). However, the in vivo effects on allergic inflammation have not been identified to date. Aims: To investigate the treatment results of PYC on allergic inflammation in a rat model of allergic rhinitis. Study Design: Animal experimentation. Methods: Allergic rhinitis was stimulated in 42 rats by intraperitoneal sensitization and intranasal challenge with Ovalbumin. The animals were divided into six subgroups: healthy controls, AR group, AR group treated with corticosteroid (dexamethasone 1 mg/kg; CS+AR), healthy rats group that were given only PYC of 10 mg/kg (PYC10), AR group treated with PYC of 3mg/kg (PYC3+AR), and AR group treated with PYC of 10 mg/kg (PYC10+AR). Interferon-γ (IFN-γ), interleukin-4 (IL-4), interleukin-10 (IL-10), and OVA-specific immunoglobulin E (Ig-E) levels of serum were measured. Histopathological changes in nasal mucosa and expression of tumor necrosis factor-α (TNF-α) and IL-1β were evaluated. Results: The levels of the IL-4 were significantly decreased in the PYC3+AR, PYC10+AR and CS+AR groups compared with the AR group (p=0.002, p<0.001, p=0.006). The production of the IFN-γ was significantly decreased in the PYC3+AR and PYC10+AR groups compared with the AR group (p=0.013, p=0.001). The administration of PYC to allergic rats suppressed the elevated IL-10 production, especially in the PYC3+AR group (p=0.006). Mucosal edema was significantly decreased respectively after treatment at dose 3 mg/kg and 10 mg/kg PYC (both, p<0.001). The mucosal expression of TNF-α has significantly decreased in the PYC3+AR and PYC10+AR groups (p=0.005, p<0.001), while the IL-1β expression significantly decreased in the CS+AR, PYC3+AR, and PYC10+AR groups (p<0.001, p=0.003, p=0.001). Conclusion: PYC has multiple suppressive effects on allergic response. Thus, PYC may be used as a supplementary agent in allergic response

Protective effect of Pycnogenol on cisplatin-induced ototoxicity in rats

Context: Pycnogenol((R)), which is French maritime pine bark extract, is a potent antioxidant. It is used in medical conditions caused by oxidative stress. Cisplatin (cis-diamminedichloroplatinum II) is an antineoplastic agent. However, its serious side effects such as ototoxicity limit its usage.Objective: Antioxidants can be used to prevent ototoxicity. We investigated the effect of Pycnogenol((R)) on cisplatin-induced ototoxicity.Materials and methods: Rats were randomly assigned to four groups of five. Distortion product-evoked otoacoustic emissions (DPOAE) test was performed for each rat. The experimental groups were as follows: Control Group, Pycnogenol((R)) Group: 10mg/kg Pycnogenol((R)) intraperitoneally for 7 days, Cisplatin Group: intraperitoneally 15mg/kg single injection of cisplatin on the fifth day, Cisplatin+Pycnogenol((R)) Group: intraperitoneally 10mg/kg Pycnogenol((R)) treatment for 7 days, additionally on the fifth day, 15mg/kg single injection of cisplatin was given. On the eighth day, DPOAE was re-performed and rats were sacrificed. Apoptosis was evaluated histopathologically.Results: Mean percentage of apoptotic cells was 1.5, 3, 30 and 11% in organ of Corti and 2, 2, 40, 15% in spiral ganglion neurons in Control Group, Pycnogenol((R)) Group, Cisplatin Group and Cisplatin+Pycnogenol((R)) Group, respectively. Cisplatin Group and Cisplatin+Pycnogenol((R)) Group were significantly different when compared to Control Group histopathologically both in organ of Corti and spiral ganglion neuron (p<0.001, p=0.019, p=0.001, p=0.015). DPOAE results showed that Cisplatin+Pycnogenol((R)) Group was significantly different when compared to Cisplatin Group at 3, 6 and 8kHz (p<0.05).Conclusion: Pycnogenol protected against cisplatin ototoxicity. Also, pycnogenol is not ototoxic

Evaluation of Lapatinib and Trastuzumab for Ototoxic Effects

OBJECTIVE: Trastuzumab and lapatinib are widely used chemotherapeutic agents. Our aim in this study was to assess the possible ototoxicity of these chemotherapeutic agents

Kültürel Bellek 2016

Hacettepe Üniversitesi Tarihi ve Kültürel Mirası Araştırma Merkezi HÜTKAM olarak kültürel bellek çalışmalarına katkıda bulunmayı görevimiz kabul ediyoruz. 2016 yılında, yönetim kurulu olarak bu serüvene başlamaya karar verdik. Güvendiğimiz dostlarımız, arkadaşlarımız ve elbette hocalarımız çağrımızı yanıtsız bırakmadı. Birbirinden değerli araştırmalarla zenginleştik ve tarihe not düşmek adına kültürel bellek çalışmalarına biz de katıldık. Kültürel mirasın evrensel olduğu, oralı/buralı, sizden/bizden, uzak/yakın ayırmadan, hepimizin olduğu fikrinden yola çıktık. Bizi biz yapan, toplumları oluşturan, birleştiren kültürel belleğimizdir. Kimi zaman insan eliyle, cehaletle, yıkıcılıkla bazen adamsendecilikle, bilinçsizlikle tahrip edilen, yok edilen tarihi ve kültürel miras, belleğimizin önemli, çok önemli bir parçasıdır. Her zaman önünden geçtiğimiz bir yapı bir gecede yıkıldıysa, çocukluk anılarımızı biriktirdiğimiz mahallemiz yok olduysa, sokağımızın, meydanımızın adı değiştiyse eksiliriz. Bizi büyüten oyunlar kaybolduysa, bir tekerleme artık hatırlanmıyorsa, çocukluğumuzun sanatçıları göçmüşse, eski şarkılar plaklarda bile yoksa eksiliriz. Hafızamızı tetikleyen imgeler, kokular, sesler, tatlar değişirse bireysel belleğimiz, yaşadığımız kentin ve toplumun belleği zarar görür, eksiliriz. Bireysel tarihimizde, belleğimizdeki insanları yitirdikçe nasıl azalıyorsak tarihi ve kültürel mirası, ortak belleği yitirdikçe de öyle zayıflar ve giderek yok oluruz. İşte bu nedenle biz hatırlamayı, öğrenmeyi, görmeyi, araştırmayı seçiyoruz. Unutmamak için, unutulduysa hatırlamak ve hatırlatmak için, bilmeyenlere göstermek, anlatmak ve belleğimize sahip çıkmak için başladığımız bu serüvende çağrımızı kırmayan değerli araştırmacılara şükranlarımızı sunuyoruz. Unutmayalım ki kültürel bellek, hepimizi birleştiren güçtür