Novel SNARE Complex Polymorphisms Associated with Multiple Sclerosis: Signs of Synaptopathy in Multiple Sclerosis

Background: It is well known that axonal degeneration plays a role in disability in patients with multiple sclerosis, and synaptopathy has recently become an important issue.Aims: To investigate the possible roles of selected synaptic and presynaptic membrane protein genetic polymorphisms (VAMP2, SNAP-25, synaptotagmin, and syntaxin 1A) in patients with multiple sclerosis.Study Design: Case-control study.Methods: A total of 123 patients with multiple sclerosis and 192 healthy controls were included. The functional polymorphisms of specific SNARE complex proteins (VAMP2, synaptotagmin XI, syntaxin 1A, and SNAP-25) were analyzed by polymerase chain reaction.Results: Significant differences were detected in the genotype and allele distribution of 26-bp Ins/Del polymorphisms of VAMP2 between patients with multiple sclerosis and control subjects; Del/Del genotype and Del allele of VAMP2 were more frequent in patients with multiple sclerosis (p=0.011 and p=0.004, respectively). Similarly, Ddel polymorphism of SNAP-25 gene C/C genotype (p=0.059), syntaxin 1A T/C and C/C genotypes (p=0.005), and synaptotagmin XI gene C allele (p=0.001) were observed more frequently in patients with multiple sclerosis. CC, syntaxin rs1569061 1A gene for 33-bp promoter region TC haplotypes, and synaptotagmin XI gene were found to be associated with an increased risk for multiple sclerosis (p=0.012). Similarly, GC haplotype for rs3746544 of SNAP-25 gene and rs1051312 of SNAP-25 gene were associated with an increased risk for multiple sclerosis (p=0.022).Conclusion: Genetic polymorphisms of SNARE complex proteins, which have critical roles in synaptic structure and communication, may play a role in the development of multiple sclerosis

The contribution of vacuum-assisted modified Menghini type needle to diagnosis of US-guided fine needle aspiration biopsy of the thyroid

PURPOSEWe aimed to determine the contribution of vacuum-assisted modified Menghini type needle to diagnosis of ultrasound-guided fine needle aspiration biopsy (FNAB) of the thyroid evaluated by a pathologist at the bedside.METHODSA total of 147 thyroid nodules in 138 patients (122 women, 16 men) were included in this prospective study. Sonographic features of nodules, number of aspirations, pain and pain severity during the process, hemorrhage, and presence of sample obtained for cell block analysis were recorded and analyzed with the results of aspiration biopsy.RESULTSUsing the 21G modified Menghini type needle, a diagnosis could not be reached in 14.3% of nodules. Adequate samples for cell block analysis were obtained in 47 nodules (32%), 17 of which contributed to the diagnosis. While the difference between diagnostic cytopathology results and the contribution of the cell block were statistically significant, obtainability of cell block samples was not significantly correlated with the number of aspirations or the presence of a cystic component in the nodule.CONCLUSIONFNAB with 21G vacuum-assisted modified Menghini type needle is a safe procedure with very low complication rates. In addition to the cytologic smear samples, microtissue fragments obtained with this method help pathologists in the diagnosis of thyroid nodules

DETERMINING THE FACTORS THAT AFFECT TAXPAYERS’PERSPECTIVE ON TAX ADMINISTRATION: RESEARCH IN TURKEY

Countries that have restructured their tax administration often use a "withtaxpayer" approach rather than a "despite taxpayer"approach and have organizedtax administrations in the form of taxpayer-focusedstructures. Parallel to thisapproach, changes in taxpayers’ perspectives have gained importance, and studieshave begun to examine this perspective. Taxpayers’perspectives on taxadministration are determined by various factors. Based on empirical datacollected from a survey of 680 respondents in Turkey, this study seeks to identifyfactors that influence taxpayers’ perspectives on tax administration. These factors include fairness, trust, taxpayers’ rights, resistance, respect, technology use,consultation, and outcomes favorability. A factor analysis is used to analyze theeffects of these variables on taxpayers’ perspectives on tax administration. Theresults indicate that fairness and trust in the administration have a significantimpact on taxpayers’ perspectives. The implicationsof these results are discussed

Çinko Fosfür İçeren Fare Zehiri ile Özkıyım Girişimi Olgu Sunumu

Çinko fosfür rodentisit olarak kullanılan toksik kimyasal bir ajandır. Etkileri kalp, akciğer, böbrek ve gastrointestinal sistem üzerinedir. Metabolik asidoz, amilaz yüksekliği, karaciğer hasarı, hipotansiyon, şok ve kardiyak aritmi görülmektedir. Kırkbir yaşında erkek hasta özkıyım amacıyla çinko fosfür içeren fare zehiri alımı hikayesiyle değerlendirildi. Solunum sıkıntısı, aritmi, istemsiz yaygın kas kasılması, metabolik asidoz, koagülasyon bozukluğu, amilaz, AST ve LDH yüksekliği tespit edildi. Yoğun bakım takibi sonrası iyilik haliyle taburcu edildi. Bu yazıda, özkıyım amacıyla çinko fosfür alan olgunun yoğun bakım ünitesindeki takip-tedavi sürecinde yaşadığımız tecrübenin genel bilgiler eşliğinde paylaşılması amaçlanmıştır. Anahtar kelimeler: Fare zehiri, Çinko fosfür, İntihar, Metabolik asidoz, Yüksek amilaz

Suicide Attempt with Rodenticide Including Zinc Phosphide: Case Report

Çinko fosfür rodentisit olarak kullanılan toksik kimyasal bir ajandır. Etkileri kalp, akciğer, böbrek ve gastrointestinal sistem üzerinedir. Metabolik asidoz, amilaz yüksekliği, karaciğer hasarı, hipotansiyon, şok ve kardiyak aritmi görülmektedir. Kırkbir yaşında erkek hasta özkıyım amacıyla çinko fosfür içeren fare zehiri alımı hikayesiyle değerlendirildi. Solunum sıkıntısı, aritmi, istemsiz yaygın kas kasılması, metabolik asidoz, koagülasyon bozukluğu, amilaz, AST ve LDH yüksekliği tespit edildi. Yoğun bakım takibi sonrası iyilik haliyle taburcu edildi. Bu yazıda, özkıyım amacıyla çinko fosfür alan olgunun yoğun bakım ünitesindeki takip-tedavi sürecinde yaşadığımız tecrübenin genel bilgiler eşliğinde paylaşılması amaçlanmıştır.Zinc phosphide is a toxic chemical agent used as a rodenticide. The effects are on heart, lung, kidney and gastrointestinal tract. Metabolic acidosis, high amylase, liver damage, hypotension, shock and cardiac arrhythmia is observed. Forty-year-old male patient evaluated with a history of taking zinc phosphide containing rat poison in order to commit suicide. Respiratory distress, arrhythmias, commonly involuntary muscle contraction, metabolic acidosis, coagulation disorders, amylase, AST and LDH levels were determined. Term follow-up after intensive care unit and was discharged favor. In this paper, for the purpose of suicide zinc phosphide our experiences in the field of public information in the cases of ICU follow-up treatment process is intended to share the accompaniment

A Case of Peduncular Hallucinosis Secondary to a Tuberothalamic Artery Infarction and Review of the Literature

Peduncular hallucinosis is a rare syndrome characterized with visual hallucinations, sleep disorders and behavioural abnormalities. Generally it occurs when thalamus and midbrain is affected by vascular lesions. In this report we aim to discuss on a case of tuberothalamic artery infarction presenting with peduncular hallusinosis with the previously reported cases in literatüre

Novel SNARE Complex Polymorphisms Associated with Multiple Sclerosis: Signs of Synaptopathy in Multiple Sclerosis

Background: It is well known that axonal degeneration plays a role in disability in patients with multiple sclerosis, and synaptopathy has recently become an important issue. Aims: To investigate the possible roles of selected synaptic and presynaptic membrane protein genetic polymorphisms (VAMP2, SNAP-25, synaptotagmin, and syntaxin 1A) in patients with multiple sclerosis. Study Design: Case-control study. Methods: A total of 123 patients with multiple sclerosis and 192 healthy controls were included. The functional polymorphisms of specific SNARE complex proteins (VAMP2, synaptotagmin XI, syntaxin 1A, and SNAP-25) were analyzed by polymerase chain reaction. Results: Significant differences were detected in the genotype and allele distribution of 26-bp Ins/Del polymorphisms of VAMP2 between patients with multiple sclerosis and control subjects; Del/Del genotype and Del allele of VAMP2 were more frequent in patients with multiple sclerosis (p=0.011 and p=0.004, respectively). Similarly, Ddel polymorphism of SNAP-25 gene C/C genotype (p=0.059), syntaxin 1A T/C and C/C genotypes (p=0.005), and synaptotagmin XI gene C allele (p=0.001) were observed more frequently in patients with multiple sclerosis. CC, syntaxin rs1569061 1A gene for 33-bp promoter region TC haplotypes, and synaptotagmin XI gene were found to be associated with an increased risk for multiple sclerosis (p=0.012). Similarly, GC haplotype for rs3746544 of SNAP-25 gene and rs1051312 of SNAP-25 gene were associated with an increased risk for multiple sclerosis (p=0.022). Conclusion: Genetic polymorphisms of SNARE complex proteins, which have critical roles in synaptic structure and communication, may play a role in the development of multiple sclerosis

Epileptic seizures in cerebral venous sinus thrombosis: Subgroup analysis of VENOST study

Purpose: The aim of this study is to evaluate the presence and prognostic impact of early seizures in cerebral venous sinus thrombosis patients (CVST).Method: VENOST is a retrospective and prospective national multicenter observational study. CVST patients with or without epileptic seizures (ES) were analyzed and compared in terms of demographic and imaging data, causative factors, clinical variables, and prognosis in a total of 1126 patients.Results: The mean age of the patients in the ES group was 39.73 +/- 12.64 and 40.17 +/- 14.02 years in the non-ES group (p > 0.05). Epileptic seizures were more common (76.6 %) in females (p < 0.001). Early ES occurred in 269 of 1126 patients (23.9 %). Epileptic seizures mainly presented in the acute phase (71.4 %) of the disease (p < 0.001). Majority of these (60.5 %) were in the first 24 h of the CVST. The most common neurological signs were focal neurologic deficits (29.9 %) and altered consciousness (31.4 %) in the ES group. Superior sagittal sinus (SSS) and cortical veins (CV) involvement were the most common sites of thrombosis and the mostly related etiology were found puerperium in seizure group (30.3 % vs 13.9 %). Patients with seizures had worse outcome in the first month of the disease (p < 0.001) but these did not have any influence thereafter.Conclusions: In this largest CVST cohort (VENOST) reported female sex, presence of focal neurological deficits and altered consciousness, thrombosis of the SSS and CVs, hemorrhagic infarction were risk factors for ES occurrence in patients with CVST

Epileptic seizures in cerebral venous sinus thrombosis: Subgroup analysis of VENOST study

Purpose: The aim of this study is to evaluate the presence and prognostic impact of early seizures in cerebral venous sinus thrombosis patients (CVST). Method: VENOST is a retrospective and prospective national multicenter observational study. CVST patients with or without epileptic seizures (ES) were analyzed and compared in terms of demographic and imaging data, causative factors, clinical variables, and prognosis in a total of 1126 patients. Results: The mean age of the patients in the ES group was 39.73 +/- 12.64 and 40.17 +/- 14.02 years in the non-ES group (p > 0.05). Epileptic seizures were more common (76.6 %) in females (p < 0.001). Early ES occurred in 269 of 1126 patients (23.9 %). Epileptic seizures mainly presented in the acute phase (71.4 %) of the disease (p < 0.001). Majority of these (60.5 %) were in the first 24 h of the CVST. The most common neurological signs were focal neurologic deficits (29.9 %) and altered consciousness (31.4 %) in the ES group. Superior sagittal sinus (SSS) and cortical veins (CV) involvement were the most common sites of thrombosis and the mostly related etiology were found puerperium in seizure group (30.3 % vs 13.9 %). Patients with seizures had worse outcome in the first month of the disease (p < 0.001) but these did not have any influence thereafter. Conclusions: In this largest CVST cohort (VENOST) reported female sex, presence of focal neurological deficits and altered consciousness, thrombosis of the SSS and CVs, hemorrhagic infarction were risk factors for ES occurrence in patients with CVST.WOS:0005375741000192-s2.0-85083703251PubMed: 3235381