Ankaferd influences mRNA expression of iron-regulated genes during iron-deficiency anemia

Ankaferd Blood Stopper (ABS) comprises a mixture of plants and stops bleeding via forming a protein network by erythroid aggregation. Bleeding causes reduction of iron levels in body. It has been indicated that ABS contains significant amount of iron. Thus, we investigated the biological activity of ABS-derived iron on iron-regulated genes during iron-deficiency anemia (IDA). IDA We selected Caco-2 and HepG2 cell lines as in vitro models of human intestine and liver, respectively. Iron deficiency anemia was induced by deferoxamine. The cells were treated with ferric ammonium citrate (FAC) and ABS. Messenger RNA levels of iron-regulated genes were analyzed by quantitative reverse transcription polymerase chain reaction to elucidate whether iron in ABS behaved similar to inorganic iron (FAC) during IDA. The results showed that ABS-derived iron influenced transcriptions of iron-regulated marker genes, including divalent metal transporter (Dmt1), transferrin receptor (TfR), ankyrin repeat domain 37 (Ankrd37), and hepcidin (Hamp) in IDA-induced Caco-2 and HepG2 cells. Our results suggest that when ABS is used to stop tissue bleeding, it might have an ability to reduce levels of IDA

Coordinated task manipulation by nonholonomic mobile robots

Coordinated task manipulation by a group of autonomous mobile robots has received signicant research effort in the last decade. Previous studies in the area revealed that one of the main problems in the area is to avoid the collisions of the robots with obstacles as well as with other members of the group. Another problem is to come up with a model for successful task manipulation. Signicant research effort has accumulated on the denition of forces to generate reference trajectories for each autonomous mobile robots engaged in coordinated behavior. If the mobile robots are nonholonomic, this approach fails to guarantee successful manipulation of the task since the so-generated reference trajectories might not satisfy the nonholonomic constraint. In this work, we introduce a novel coordinated task manipulation model inclusive of an online collision avoidance algorithm. The reference trajectory for each autonomous nonholonomic mobile robot is generated online in terms of linear and angular velocity references for the robot; hence these references automatically satisfy the nonholonomic constraint. The generated reference velocities inevitably depend on the nature of the specied coordinated task. Several coordinated task examples, on the basis of a generic task, have been presented and the proposed model is veried through simulations

Rom traditional to new instruments: the role of public diplomacy in conflict prevention

There has been an increase in the number and activity of global actors who are not states; the information revolution has changed the diplomacy field as well as information gathering is concerned; and diplomacy now involves many more participants who are experts in matters other than diplomacy, and hold their positions outside foreign ministries. Public diplomacy is about building relationships that comprises understanding the needs of other countries, cultures and peoples, communicating the points of view and correcting misperceptions. This paper highlights the role and importance of public diplomacy for conflict prevention in international arena. Diplomacy is always based on dialogue, usually between two countries, and dialogue is a crucial element of success as a mean for resolving conflict. Whether the conflict has a historical dimension or is the result of current circumstances, it is important to bring the sides together. When governments do not want or cannot engage in dialogue, it is important to involve parties from the non-government sector. Although in itself will not be the sole solution for peace between the countries, public diplomacy can implement programs to strengthen mutual trust, both within countries with a high degree of risk and in areas with conflict potential. Accordingly, after definition of diplomacy in a general framework, the evolution and role of public diplomacy mechanisms in conflict prevention will be elaborated in this paper

Turkish discourse on Arab upheavals in international environment: Post-structural analysis of un general assembly speeches (2011-2018)

With the outbreak of the grassroots movements in December 2010, the conjuncture of the Middle East began to undergo a major transformation. The first demonstrations took place in Central Tunisia, and after a while, a series of anti-government protests, uprisings, and armed rebellions spread across the whole region. With this process, defined as “Arab Spring”, any country affected by the rebellion wave has experienced different political developments and started to follow different routes. Turkey, as a regional country, has not only monitor developments, but instead followed a very active foreign policy towards the transformations occurred. The aim of this paper is to understand and situate Turkish discourse about Arab upheavals in the international environment, specifically in UN General Assembly. Through asking “how” questions, the construction and hierarchical positioning of different actors in the process will seek to be analyzed. The concepts of “presupposition”, “predication” and “subject positioning”, which were borrowed from Roxanne Lynn Doty, will be used as analytical categories to provide a textual framework. The representational practices through which meaning are generated is important in this study. Accordingly, the discursive identities produced by Turkish elites with their speech acts will be examined throughout the time in order to understand the attachments to various social objects and subjects in the region. Thus, both continuity and change within the Turkish discourse would be put forward.Mayı

Meşreb'in Kitab-ı Medbe-i Nur'u Mevlana'nın Mesnevi'sinin Şerhi Midir?

[No Abstract Available

Problem Solving Skills in Social Studies Education and Problem Solving Skills of Social Studies Teachers

Problem solving skills are mentioned among the skills which need to be acquired in the Social Studies course. In this study, how the social studies teachers perceived problem solving skills was examined by emphasizing the importance of having individuals acquire problem solving skills through social studies teaching. The sample of the study was composed of social studies teachers. In order to evaluate the preservice teachers' perceptions in relation to problem solving skills, the "Problem Solving Inventory" developed by Heppner and Petersen (1982) and adapted by Şahin, Şahin and Heppner (1993) into Turkish was used. In the analysis of the data, firstly if the obtained data distributed normally was tested with Kolmogorov-Smirnov test. Since the data obtained from the problem solving inventory showed normal distribution, the Independent Samples T test was used for paired comparisons and One-Way ANOVA was used for multiple comparisons. It was found that the teachers' problem solving skills did not differ significantly according to the variables of gender, age, marital status, length of service and educational status, satisfaction from school of service, frequency of experiencing problems at their schools and the teachers' problem solving skills were at sufficient level

Characterization of the Mortars and Plasters of the Mahmut the First Library of Fatih Mosque

Eski eserlerin koruma ve onarım (restorasyon ve konservasyon) çalışmaları belgeleme, teşhis, uygulama (temizleme, yapıştırma-dolgu-tümleme, sağlamlaştırma-koruma) ve bakım aşamalarından oluşmaktadır. Onarım gerektiren uygulamalarda, eserin sorunlarının teşhisi kadar eserin orijinal malzemelerinin içeriklerinin ve niteliklerinin bilinmesi de önemlidir. Özellikle camii, kilise, saray, medrese, hamam gibi binalarla kale, köprü, çeşme, heykel gibi anıtsal yapıların üretiminde kullanılmış olan taş, tuğla, harç-sıva ve diğer orijinal malzemelerinin içerik ve niteliklerinin bilinmesi, uygulamada kullanılacak onarım malzemelerinin seçimi ve üretilmesi için bir gerekliliktir. Ancak bu bilgilerin elde edilmesiyle yan yana kullanılacak olan orijinal ve onarım malzemelerinin fiziksel, kimyasal ve mekanik özellikleri birbirleriyle uyumlu ve benzer olacaktır. Aksi takdirde sağlıklı bir onarımın yapılması pek mümkün değildir. Çünkü yan yana kullanılan orijinal ve onarım malzemeleri farklı fiziksel ve mekanik özeliklere sahip olduklarında, birbirleri üzerine mekanik baskılar yaratacaklardır. Bu baskılar sonucunda da zayıf olan yapı malzemelerinin (çoğunlukla orijinal malzemelerdir) hasar görmesi kaçınılmazdır. Bunun sonucu olarak koruma ve onarımı yapılan eser, çevre koşullarının etkisine bağlı olarak kısa veya orta vadede, orijinal malzemeleri hasar göreceğinden, tekrar onarım gerektirir hale gelecektir. Bu çalışmada, 1999 depreminden zarar görmüş, İstanbul Fatih Camii Kütüphanesinin harç ve sıva analizleri yapılmış ve değerlendirilmiştir. Analiz sonuçlarına göre harç ve sıvalar 4 grup altında toplanmıştır. Birinci grup harç ve sıvalarda bağlayıcı olarak % 30-35 oranında kaymak kireç bağlayıcı, % 0,20-0,50 kıtık katkı ile tamamı kireçtaşı kırığı olan % 65-70 dolgu kullanılmıştır. Aynı bağlayıcı ve katkının kullanıldığı ikinci grupta dolgu olarak % 15-20 kireçtaşı kırığı ile yaklaşık % 50 oranında tuğla kırığı kullanılmıştır. % 30-35 hidrolik kirecin bağlayıcı olduğu üçüncü grup harç ve sıvalarda agrega olarak sadece tuğla kırığı kullanılmıştır. Üçüncü gruba dahil edilen ve muhtemelen 1894 depremi sonrasında üretilmiş olan harçlarda tuğla kırığı’nın yaklaşık % 30’u çakıl niteliklidir. Son dönem restorasyonu’nda kullanılmış olan Dördüncü grup harçlarda bağlayıcı olarak % 25-30 hidrolik kireç, dolgu olarak % 15-20 kireçtaşı kırığı, yaklaşık % 30 tuğla kırığı ve % 30 kum kullanılmıştır. Fatih Camii Kütüphanesini restorasyonunda kullanılacak onarım harç ve sıvası olarak, alındıkları yerlere bağlı olarak birinci, ikinci ve üçüncü grup karışımlar önerilmiştir. Dördüncü gruba dahil olan yerlerde ise onarım malzemesi olarak üçüncü grup harç karışımı önerilmiştir. Böylece, onarım sonrasında, Fatih Camii I Mahmut Kütüphanesi’nin yapı teknolojisi değiştirilmezken, onarımda kullanılan yeni harç ve sıvaların orijinal malzemeler üzerine fiziksel ve mekanik baskı yapması da engellenmiş olacaktır. Bu da yapının uzun bir süre, bir problem ve onarımla karşılaşmadan sağlıklı yaşamasını sağlayacaktır

"He can recite a poem every form" The Evaluation of Poem and Poem in Osmanli Muellifleri

Bursalı Mehmet Tahir'in Osmanlı Muellifleri isimli eseri araştırmacılar için mutlaka görülmesi gereken kaynaklardandır. Bu biyografik eserinde Bursalı, müellifleri Osmanlı Devleti'nde her hangi bir konuda eser vermiş yazarları mesleklerine göre tasnif ederek yazarı ve eserleri hakkında bilgi vermektedir. Üç ciltlik eserin ikinci cildinde Osmanlı şairlerinden bahsettiği bölümde şairlerin hayatı hakkında bilgi vermenin yanı sıra şairlikleri ve şiirleri hakkında da değerlendirmelerde bulunmaktadır. Bu yazıda Bursalı Mehmet Tahir'in bu değerlendirmelerinin nesnel/eleştirel olup olmadığı tartışılmış ve Bursalı'nın şair ve şiir anlayışının ortaya konulmasına çalışılmıştır. The work Osmanlı Muellifleri written by Bursalı Mehmet Tahir is significant for all researchers. Bursalı's biographical work categorises all authors who wrote about any subject within the Ottoman State according to their profession and provides information regarding their works. The second volume of the 3-volume output not only gives information regarding the authors' lives but also mentions their poetic qualities and the poems they wrote. The study discusses if Bursalı Mehmet Tahir's examinations are of an objective/critical nature and attempts to reveal Bursalı's understanding of poets and poetry

Cultural diplomacy and Turkey in the age of globalization

In today’s political world, diplomatic means play a significant role in a country’s efforts to achieve political goals and to promote its image in the international arena. Diplomatic channels are also being used by the governments rather than relying solely on military and economic means in their interactions with other countries. Moreover, in contrast to state-based diplomacy, which involves interactions between governments, nowadays, states’ diplomatic efforts are targeted at people as well. This paper examines the concept and practice of cultural diplomacy. Cultural diplomacy is carried out by a government to support its foreign policy goals or diplomacy or both by using a wide range of cultural manifestations for a number of purposes. In line with these discussions, the paper examines aspects of the cultural diplomacy of Turkey in order to understand how cultural diplomacy has been used as an important tool by Turkey within its relations with the Middle East in recent period with its limitations