Structural features of jammed-granulate metamaterials

Granular media near jamming exhibit fascinating properties, which can be harnessed to create jammed-granulate metamaterials: materials whose characteristics arise not only from the shape and material properties of the particles at the microscale, but also from the geometric features of the packing. For the case of a bending beam made from jammed-granulate metamaterial, we study the impact of the particles' properties on the metamaterial's macroscopic mechanical characteristics. We find that the metamaterial's stiffness emerges from its volume fraction, in turn originating from its creation protocol; its ultimate strength corresponds to yielding of the force network. In contrast to many traditional materials, we find that macroscopic deformation occurs mostly through affine motion within the packing, aided by stress relieve through local plastic events, surprisingly homogeneously spread and persistent throughout bending

Cost-effectiveness of Interferon-free therapy for Hepatitis C in Germany - an application of the efficiency frontier approach

Background:The approval of direct-acting antivirals for Interferon-free treatment revolutionized the therapy of chronic Hepatitis C infection. As of August 2014, two treatment regimens for genotype 1 infection received conditional approval in the European Union: Sofosbuvir and Ribavirin for 24 weeks and Sofosbuvir and Simeprevir with or without Ribavirin for 12 weeks. We aim to analyze the cost-effectiveness of both regimens in Germany. Methods: We set up a Markov model with a lifetime horizon to simulate immediate treatment success and long-term disease progression for treatment-naive patients. The model analyzes both short-term and long-term costs and benefits from the perspective of the German Statutory Health Insurance. We apply the efficiency frontier method, which was suggested by German Institute for Quality and Efficiency in Health Care for cost-effectiveness analysis in Germany. Results: The efficiency frontier is defined by dual therapy and first generation direct-acting antiviral Boceprevir, yielding a maximum of € 1,447.69 per additional percentage point of sustained virologic response gained. Even without rebates, Sofosbuvir/Simeprevir is very close with € 1,560.13 per additional percentage point. It is both more effective and less expensive than Sofosbuvir/Ribavirin. Conclusions: In addition to higher sustained virologic response rates, new direct-acting antivirals save long-term costs by preventing complications such as liver cirrhosis, hepatocellular carcinoma and ultimately liver transplants, thereby offsetting part of higher drug costs. Our findings are in line with the guidance published by German Society for Gastroenterology, Digestive and Metabolic Diseases, which recommends Sofosbuvir/Simeprevir for Interferon ineligible or intolerant patients

Methane distribution at high spatial resolution in North Sea estuaries

Rivers are suspected to be a main suppliers of greenhouse gases (methane and carbon dioxide) to coastal seas, while the role of the interjacent tidal flats is still ambiguous. In this study we investigated the role of the Elbe and Weser estuaries as source of methane to the North Sea. We used high spatially resolved methane measurements from an underway degassing system and subsequent analysis with cavity ring down spectroscopy. Thus, a high-resolution representation of the methane distribution in surface waters as well as of hydrographic parameters was obtained for several cruises with two ships in 2019. For most areas, riverine methane was simply diluted by seawater, overlain by a strong tidal signal. However, on several occasions unexpectedly high methane concentrations were observed. Further detailed analysis will elucidate the role of riverine versus tidal impact on coastal North Sea methane fluxes

Granular meta-material: response of a bending beam

Jammed granular matter can be considered a meta-material that behaves viscoelastic for small deformations. We characterize the elastic properties of the meta-material through the response of a simply supported bending beam consisting of jammed granular matter under weak load and quasistatic deformation.Open Access funding enabled and organized by Projekt DEAL.Deutsche ForschungsgemeinschaftFriedrich-Alexander-Universität Erlangen-Nürnberg (1041

GraphMatch: Subgraph Query Processing on FPGAs

Efficiently finding subgraph embeddings in large graphs is crucial for many application areas like biology and social network analysis. Set intersections are the predominant and most challenging aspect of current join-based subgraph query processing systems for CPUs. Previous work has shown the viability of utilizing FPGAs for acceleration of graph and join processing. In this work, we propose GraphMatch, the first genearl-purpose stand-alone subgraph query processing accelerator based on worst-case optimal joins (WCOJ) that is fully designed for modern, field programmable gate array (FPGA) hardware. For efficient processing of various graph data sets and query graph patterns, it leverages a novel set intersection approach, called AllCompare, tailor-made for FPGAs. We show that this set intersection approach efficiently solves multi-set intersections in subgraph query processing, superior to CPU-based approaches. Overall, GraphMatch achieves a speedup of over 2.68x and 5.16x, compared to the state-of-the-art systems GraphFlow and RapidMatch, respectively

Рабочие характеристики синхронных реактивных двигателей при переменной частоте

В работе рассмотрен метод расчета рабочих характеристик синхронных реактивных двигателей при переменной частоте. Проведен анализ влияния частоты, законов регулирования напряжения, величины и характера изменения момента нагрузки на рабочие характеристики. Расчетные рабочие характеристики сравниваются с экспериментальными

Structural features of jammed-granulate metamaterials

Granular media near jamming exhibit fascinating properties, which can be harnessed to create jammed-granulate metamaterials: materials whose characteristics arise not only from the shape and material properties of the particles at the microscale but also from the geometric features of the packing. For the case of a bending beam made from jammed-granulate metamaterial, we study the impact of the particles' properties on the metamaterial's macroscopic mechanical characteristics. We find that the metamaterial's stiffness emerges from its volume fraction, in turn originating from its creation protocol; its ultimate strength corresponds to yielding of the force network. In contrast to many traditional materials, we find that macroscopic deformation occurs mostly through affine motion within the packing, aided by stress relief through local plastic events, surprisingly homogeneously spread and persistent throughout bending

Digital product passport : the ticket to achieving a climate neutral and circular European economy?

The introduction of a Digital Product Passport (DPP) is an opportunity to create a system that can store and share all relevant information throughout a product's life cycle. This would provide industry stakeholders, businesses, public authorities and consumers with a better understanding of the materials used in the product as well as their embodied environmental impact. With the COVID-19 pandemic, the Russian invasion of Ukraine and the cost-of-living crisis, now is a critical moment to transform our economic and business models, while also addressing the huge scale of material emissions. DPPs can be a pivotal policy instrument in this goal. Furthermore, DPPs can accelerate the twin green and digital transitions as part of EU efforts to deliver positive climate action and sustainable economies. In 2020, the European Commission (EC) adopted a new Circular Economy Action Plan (CEAP), which emphasised the need for circular economy initiatives to consider the entire life cycle of products, from the production of basic materials to end-of-life disposal. The Circular Economy Package published in March 2022 includes a proposal for an Ecodesign for Sustainable Products Regulation (ESPR), which builds upon the Ecodesign Directive that covers energy-related products. A DPP will form a key regulatory element of the ESPR by enhancing the traceability of products and their components. This will provide consumers and manufacturers with the information needed to make better informed choices by taking their environmental impact into consideration. As discussed in the report, there is widespread agreement amongst business leaders that a well-designed DPP could have both short- and longer-term benefits, improving access to reliable and comparable product sustainability information for businesses, consumers and policymakers. A well-designed DPP can unify information, making it more readily accessible to all actors in the supply chain. This will support businesses to ensure an effective transformation towards a decarbonised industry. It could also create incentives for companies to make their products more sustainable, as improving access to reliable and consistent information across supply chains will make it easier for customers to make comparisons