Analysis of Forces Involved in the Perching Maneuver of Flapping-Wing Aerial Systems and Development of an Ultra-Lightweight Perching System

Trying to optimize the design of aerial robotics systems, this work presents an optimized low-weight landing system for flapping-wing aerial robots. The design, based on the use of low-sized neodymium magnets, intends to provide that these aerial robots have the capability of landing in restricted areas by using the presented solution. This capacity will increase the application range of these robots. A study of this situation has been done to analyze the perching maneuver forces and evaluate the system. The solution presented is low-weight, lowsized, and also relatively inexpensive. Therefore, this solution may apply to most ornithopter robots. Design, analysis of the implied forces, development and experimental validation of the idea are presented in this work, demonstrating that the developed solution can overcome the ornithopter’s payload limitation providing an efficient and reliable solutionUnión Europea SI-1867/23/2018 ERC-AD

Treatment of congenital atypical haemangiosarcoma in a foal

Haemangiosarcoma is a rare vascular tumour in horses, usually originating from blood vessel endothelial cells. We present the case of an 8-day-old foal, referred for an atypical large subcutaneous mass on the left side since birth. Ultrasonographically, it showed multiple cavities with hypoechoic content, marked vascularisation and fluid movement between cavities. As the nature of the mass suggested that surgery could result in profuse bleeding, we decided to perform an initial arteriography to identify the pattern and calibre of the main vessels and embolisation of this vascular supply, which allowed surgical removal with less bleeding than expected. This approach, with pre-surgical transarterial embolisation of the tumour, is not commonly used in equine surgery. Histology established a diagnosis of cutaneous haemangiosarcoma. During 1-year post-surgery, clinical and ultrasound examinations were carried out without any signs of recurrence or metastasis. One year later, the foal was euthanised due to a limb fracture. No macroscopic signs of metastasis were observed at necropsy. Histology showed no signs of recurrence. Cutaneous haemangiosarcomas, though rare, should be included in the differential of masses and growths with compatible ultrasound or cytological findings. Transcatheter arterial embolisation of highly vascularised neoplasms can reduce bleeding and facilitate subsequent surgical resection

A ground system for early forest fire detection based on infrared signal processing

This article presents a ground remote automatic system for forest surveillance based on infrared signal processing applied to early fire detection. Advanced techniques, which are based on infrared signal processing, are used in order to process the captured images. With the aim of determining the presence or absence of fire, the system performs the fusion of different detectors that exploit different expected characteristics of a real fire, such as persistence and increase. Theoretical simulations and practical results are presented to corroborate the control of the probability of false alarm. Results in a real environment are also presented to authenticate the accuracy of the operation of the proposed system. In particular, some experiments have been done to evaluate the delay of the system (tens of seconds on average) in detecting a controlled ground fire in a range of 1-10 km. Moreover, temporary evolution of false alarms and true detections are presented to evaluate the long-term performance of the system in a real environment. We have reached a detection probability of 100% at a false alarm rate of around 1 x 10(-9).This work has been supported by Generalitat Valenciana, under grant GVEMP06/001, and by MEC under the FPU programme.Bosch Roig, I.; Gómez, S.; Vergara Domínguez, L. (2011). A ground system for early forest fire detection based on infrared signal processing. International Journal of Remote Sensing. 32(17):4857-4870. https://doi.org/10.1080/01431161.2010.490245S485748703217Arrue, B. C., Ollero, A., & Matinez de Dios, J. R. (2000). An intelligent system for false alarm reduction in infrared forest-fire detection. IEEE Intelligent Systems, 15(3), 64-73. doi:10.1109/5254.846287Bernabeu, P., Vergara, L., Bosh, I., & Igual, J. (2004). A prediction/detection scheme for automatic forest fire surveillance. Digital Signal Processing, 14(5), 481-507. doi:10.1016/j.dsp.2004.06.003Briz, S. (2003). Reduction of false alarm rate in automatic forest fire infrared surveillance systems. Remote Sensing of Environment, 86(1), 19-29. doi:10.1016/s0034-4257(03)00064-6Pastor, E. (2003). Mathematical models and calculation systems for the study of wildland fire behaviour. Progress in Energy and Combustion Science, 29(2), 139-153. doi:10.1016/s0360-1285(03)00017-0Vergara, L., & Bernabeu, P. (2000). Automatic signal detection applied to fire control by infrared digital signal processing. Signal Processing, 80(4), 659-669. doi:10.1016/s0165-1684(99)00159-0Vergara, L., & Bernabeu, P. (2001). Simple approach to nonlinear prediction. Electronics Letters, 37(14), 926. doi:10.1049/el:20010616Vicente, J., & Guillemant, P. (2002). An image processing technique for automatically detecting forest fire. International Journal of Thermal Sciences, 41(12), 1113-1120. doi:10.1016/s1290-0729(02)01397-

El modelo integrador y de innovación docente del Grado en Veterinaria de Zaragoza: integración en équidos

Desde hace cuatro años se ha comenzado a impartir en la Universidad de Zaragoza el nuevo Grado en Veterinaria, de 300 créditos ECTS distribuidos en 5 cursos. En el diseño de este nuevo Plan de Estudios se ha tratado de dotar a la Titulación de un enfoque basado, fundamentalmente, en las competencias que la profesión exige y la sociedad necesita de un t itulado (graduado) en veterinaria. Tras una formación inicial básica el alumno llega al CUARTO CURSO del grado, en el que las materias se han organizado en asignaturas siguiendo una estructura totalmente novedosa para los estudios de veterinaria en España. Como consecuencia de esta nueva estructura desaparecen como tales muchas de las asignaturas tradicionales que han estado presentes como asignaturas propias (con denominaciones idénticas o similares) en la práctica totalidad de los planes de estudio de veterinaria españoles desde la década de los 70 del siglo pasado. Al cursar estas asignaturas, los alumnos de esos planes, estudiábamos las particularidades de las diferentes especies animales de interés veterinario desde el enfoque, inevitablemente compartimentalizado, de esas asignaturas

Desarrollo de una aplicación informática para aprender clínica y producción equina jugando al Trivial

Introducción/objetivos: esta iniciativa surge de la puesta en común de experiencias docentes en las I Jornadas de Innovación Docente en Medicina y Cirugía Animal (Córdoba, 2011). Allí se presentaron algunas actividades que utilizan el éxito de metodologías basadas en concursos y competiciones, que consiguen que los alumnos las adopten fácilmente como métodos de aprendizaje.La actividad propuesta se basa en el popular juego TRIVIAL™ en el que equipos de alumnos contestan cuestiones de una batería de preguntas sobre veterinaria equina. Las preguntas están agrupadas por sistemas/especialidades.Se persigue crear un sistema de aprendizaje y autoevaluación formativa, que permita la evaluación de conocimientos adaptados al nivel de los alumnos de S~ del Grado en Veterinaria. Además de autoevaluar sus propios conocimientos sin la presión de un examen formal, el alumno practica la dinámica de grupo. La competitividad generada entre equipos estimula el trabajo individual y de grupo (...

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Novel genes and sex differences in COVID-19 severity.

Here we describe the results of a genome-wide study conducted in 11 939 COVID-19 positive cases with an extensive clinical information that were recruited from 34 hospitals across Spain (SCOURGE consortium). In sex-disaggregated genome-wide association studies for COVID-19 hospitalization, genome-wide significance (p < 5x10-8) was crossed for variants in 3p21.31 and 21q22.11 loci only among males (p = 1.3x10-22 and p = 8.1x10-12, respectively), and for variants in 9q21.32 near TLE1 only among females (p = 4.4x10-8). In a second phase, results were combined with an independent Spanish cohort (1598 COVID-19 cases and 1068 population controls), revealing in the overall analysis two novel risk loci in 9p13.3 and 19q13.12, with fine-mapping prioritized variants functionally associated with AQP3 (p = 2.7x10-8) and ARHGAP33 (p = 1.3x10-8), respectively. The meta-analysis of both phases with four European studies stratified by sex from the Host Genetics Initiative confirmed the association of the 3p21.31 and 21q22.11 loci predominantly in males and replicated a recently reported variant in 11p13 (ELF5, p = 4.1x10-8). Six of the COVID-19 HGI discovered loci were replicated and an HGI-based genetic risk score predicted the severity strata in SCOURGE. We also found more SNP-heritability and larger heritability differences by age (<60 or ≥ 60 years) among males than among females. Parallel genome-wide screening of inbreeding depression in SCOURGE also showed an effect of homozygosity in COVID-19 hospitalization and severity and this effect was stronger among older males. In summary, new candidate genes for COVID-19 severity and evidence supporting genetic disparities among sexes are provided

GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Data availability: Downloadable summary data are available through the GenOMICC data site (https://genomicc.org/data). Summary statistics are available, but without the 23andMe summary statistics, except for the 10,000 most significant hits, for which full summary statistics are available. The full GWAS summary statistics for the 23andMe discovery dataset will be made available through 23andMe to qualified researchers under an agreement with 23andMe that protects the privacy of the 23andMe participants. For further information and to apply for access to the data, see the 23andMe website (https://research.23andMe.com/dataset-access/). All individual-level genotype and whole-genome sequencing data (for both academic and commercial uses) can be accessed through the UKRI/HDR UK Outbreak Data Analysis Platform (https://odap.ac.uk). A restricted dataset for a subset of GenOMICC participants is also available through the Genomics England data service. Monocyte RNA-seq data are available under the title ‘Monocyte gene expression data’ within the Oxford University Research Archives (https://doi.org/10.5287/ora-ko7q2nq66). Sequencing data will be made freely available to organizations and researchers to conduct research in accordance with the UK Policy Framework for Health and Social Care Research through a data access agreement. Sequencing data have been deposited at the European Genome–Phenome Archive (EGA), which is hosted by the EBI and the CRG, under accession number EGAS00001007111.Extended data figures and tables are available online at https://www.nature.com/articles/s41586-023-06034-3#Sec21 .Supplementary information is available online at https://www.nature.com/articles/s41586-023-06034-3#Sec22 .Code availability: Code to calculate the imputation of P values on the basis of SNPs in linkage disequilibrium is available at GitHub (https://github.com/baillielab/GenOMICC_GWAS).Acknowledgements: We thank the members of the Banco Nacional de ADN and the GRA@CE cohort group; and the research participants and employees of 23andMe for making this work possible. A full list of contributors who have provided data that were collated in the HGI project, including previous iterations, is available online (https://www.covid19hg.org/acknowledgements).Change history: 11 July 2023: A Correction to this paper has been published at: https://doi.org/10.1038/s41586-023-06383-z. -- In the version of this article initially published, the name of Ana Margarita Baldión-Elorza, of the SCOURGE Consortium, appeared incorrectly (as Ana María Baldion) and has now been amended in the HTML and PDF versions of the article.Copyright © The Author(s) 2023, Critical illness in COVID-19 is an extreme and clinically homogeneous disease phenotype that we have previously shown1 to be highly efficient for discovery of genetic associations2. Despite the advanced stage of illness at presentation, we have shown that host genetics in patients who are critically ill with COVID-19 can identify immunomodulatory therapies with strong beneficial effects in this group3. Here we analyse 24,202 cases of COVID-19 with critical illness comprising a combination of microarray genotype and whole-genome sequencing data from cases of critical illness in the international GenOMICC (11,440 cases) study, combined with other studies recruiting hospitalized patients with a strong focus on severe and critical disease: ISARIC4C (676 cases) and the SCOURGE consortium (5,934 cases). To put these results in the context of existing work, we conduct a meta-analysis of the new GenOMICC genome-wide association study (GWAS) results with previously published data. We find 49 genome-wide significant associations, of which 16 have not been reported previously. To investigate the therapeutic implications of these findings, we infer the structural consequences of protein-coding variants, and combine our GWAS results with gene expression data using a monocyte transcriptome-wide association study (TWAS) model, as well as gene and protein expression using Mendelian randomization. We identify potentially druggable targets in multiple systems, including inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).GenOMICC was funded by Sepsis Research (the Fiona Elizabeth Agnew Trust), the Intensive Care Society, a Wellcome Trust Senior Research Fellowship (to J.K.B., 223164/Z/21/Z), the Department of Health and Social Care (DHSC), Illumina, LifeArc, the Medical Research Council, UKRI, a BBSRC Institute Program Support Grant to the Roslin Institute (BBS/E/D/20002172, BBS/E/D/10002070 and BBS/E/D/30002275) and UKRI grants MC_PC_20004, MC_PC_19025, MC_PC_1905 and MRNO2995X/1. A.D.B. acknowledges funding from the Wellcome PhD training fellowship for clinicians (204979/Z/16/Z), the Edinburgh Clinical Academic Track (ECAT) programme. This research is supported in part by the Data and Connectivity National Core Study, led by Health Data Research UK in partnership with the Office for National Statistics and funded by UK Research and Innovation (grant MC_PC_20029). Laboratory work was funded by a Wellcome Intermediate Clinical Fellowship to B.F. (201488/Z/16/Z). We acknowledge the staff at NHS Digital, Public Health England and the Intensive Care National Audit and Research Centre who provided clinical data on the participants; and the National Institute for Healthcare Research Clinical Research Network (NIHR CRN) and the Chief Scientist’s Office (Scotland), who facilitate recruitment into research studies in NHS hospitals, and to the global ISARIC and InFACT consortia. GenOMICC genotype controls were obtained using UK Biobank Resource under project 788 funded by Roslin Institute Strategic Programme Grants from the BBSRC (BBS/E/D/10002070 and BBS/E/D/30002275) and Health Data Research UK (HDR-9004 and HDR-9003). UK Biobank data were used in the GSMR analyses presented here under project 66982. The UK Biobank was established by the Wellcome Trust medical charity, Medical Research Council, Department of Health, Scottish Government and the Northwest Regional Development Agency. It has also had funding from the Welsh Assembly Government, British Heart Foundation and Diabetes UK. The work of L.K. was supported by an RCUK Innovation Fellowship from the National Productivity Investment Fund (MR/R026408/1). J.Y. is supported by the Westlake Education Foundation. SCOURGE is funded by the Instituto de Salud Carlos III (COV20_00622 to A.C., PI20/00876 to C.F.), European Union (ERDF) ‘A way of making Europe’, Fundación Amancio Ortega, Banco de Santander (to A.C.), Cabildo Insular de Tenerife (CGIEU0000219140 ‘Apuestas científicas del ITER para colaborar en la lucha contra la COVID-19’ to C.F.) and Fundación Canaria Instituto de Investigación Sanitaria de Canarias (PIFIISC20/57 to C.F.). We also acknowledge the contribution of the Centro National de Genotipado (CEGEN) and Centro de Supercomputación de Galicia (CESGA) for funding this project by providing supercomputing infrastructures. A.D.L. is a recipient of fellowships from the National Council for Scientific and Technological Development (CNPq)-Brazil (309173/2019-1 and 201527/2020-0)