Detection of Periodic Leg Movements by Machine Learning Methods Using Polysomnographic Parameters Other Than Leg Electromyography

The number of channels used for polysomnographic recording frequently causes difficulties for patients because of the many cables connected. Also, it increases the risk of having troubles during recording process and increases the storage volume. In this study, it is intended to detect periodic leg movement (PLM) in sleep with the use of the channels except leg electromyography (EMG) by analysing polysomnography (PSG) data with digital signal processing (DSP) and machine learning methods. PSG records of 153 patients of different ages and genders with PLM disorder diagnosis were examined retrospectively. A novel software was developed for the analysis of PSG records. The software utilizes the machine learning algorithms, statistical methods, and DSP methods. In order to classify PLM, popular machine learning methods (multilayer perceptron, K-nearest neighbour, and random forests) and logistic regression were used. Comparison of classified results showed that while K-nearest neighbour classification algorithm had higher average classification rate (91.87%) and lower average classification error value (RMSE = 0.2850), multilayer perceptron algorithm had the lowest average classification rate (83.29%) and the highest average classification error value (RMSE = 0.3705). Results showed that PLM can be classified with high accuracy (91.87%) without leg EMG record being present

Intraoral premalign ve malign lezyonlu hastaların doku örneklerindeki candida türlerinin DNA analiziyle belirlenmesi ve sağlıklı doku ile karşılaştırılması

Amaç: Bu retrospektif çalışmada premalign ve malign lezyonlu ile sağlıklı bireylere ait doku örneklerindeki Candida albicans, Candida kruseii, Candida parapsilosis, Candida tropicalis ve Candida glabrata türlerinin belirlenmesi amaçlanmıştır.  Gereç ve Yöntem: Çalışmaya oral premalign veya malign lezyon şüphesi nedeniyle biyopsi uygulanmış doku örnekleri dahil edildi. Örnekler histolojik özelliklerine göre sağlıklı (n=20), displazi (n=20), karsinoma in-situ (n=20) ve skuamoz hücreli karsinom (SHK) (n=20) olmak üzere 4 gruba ayrıldı. DNA izolasyonunun ardından Candida türlerine ait DNA örneklerinin miktar ve saflık kontrolleri gerçekleştirildi. Kantitatif ölçümler için Real-Time PCR (LightCycler 96, Almanya) kullanıldı ve standart eğriler hesaplandı. Veriler Mann-Whitney ve Wilcoxon Signed Ranks testleri ile değerlendirildi (P<0.05).Bulgular: Sağlıklı ve displazik örneklerin yer aldığı gruplarda C. parapsilosis (104DNA/50 mg) en sık görülen Candida türüydü. Karsinoma in-situ grubunda C. tropicalis ve C. kruseii (103DNA/50 mg), SHK grubunda ise C. kruseii (104DNA/50 mg) seviyelerinin daha yüksek olduğu belirlendi. Örneklerin hiçbirinde C. albicans varlığı gösterilemedi. Gruplar arasında farklı Candida türlerinin sayısına göre anlamlı bir fark gözlenmedi (P>0.05). Farklı Candida türlerinin gruplar içerisindeki seviyeleri incelendiğinde; sağlıklı örneklerde C. glabrata (103DNA/50 mg), displazi grubunda C. parapsilosis (104DNA/50 mg), karsinoma in-situ grubunda C. tropicalis-C. kruseii (103DNA/50 mg), SHK grubunda ise C. kruseii’nin (103DNA/50 mg) en fazla sayıda gözlenen Candida türü olduğu belirlendi. Candida türlerinin gruplar içerisindeki dağılımı anlamlı değildi (P>0.05).Sonuç: Sağlıklı, displazik, karsinoma in situ ve skuamöz hücreli karsinoma doku örneklerinde Real-Time PCR yöntemiyle yapılan kantitatif değerlendirmede Candida türlerinin tüm gruplarda benzer oranda mevcut oldukları belirlendi.ANAHTAR KELİMELER Oral Candida, C. albicans, ağız kanseri, Real-Time PCR, moleküler analiz &nbsp

Sustainable collection development towards greener future: Earthsavers

Nowadays, environmental awareness is more important not to damage the living environment. Sources of the Earth have been decreasing day by day due to many natural and human-induced reasons such as global warming, waste disposal, urbanization, deforestation, etc. Harm of the textile sector on the environment is high and it needs control and awareness. Raw material production, raw material selection, water usage amount, sustainability of processes, refining of wastes, recycle and reuse strategies of textile companies have a very significant effect on the environment. With this awareness, sustainable fashion is created because customer behaviors affect both design and production. In this view, all ingredients and processes turn to the most sustainable forms as much as possible. While being environmentally friendly, required performances of garments should be met to prepare the required end product. In this study, a sustainable collection whose name is Earthsavers is prepared by using recycled raw materials, natural dyestuffs, etc. Their physical and chemical performances are tested. Results of the collection are suitable for acceptance levels and it shows that a collection can be prepared with minimum harm to the environment with at least the same performances as conventional alternatives

Successful treatment of bilateral open calcaneal fractures with concomitant lower extremity injuries: A case report

Open calcaneal fractures are high morbidity injuries and the risk of complications depends on the concomitant injuries, on the size and the position of the traumatic wound. A 53-year-old male patient with bilateral open calcaneal fractures and associated concomitant lower extremity injuries such as subtalar dislocation, talonavicular dislocation and open distal tibial metaphyseal fracture was immediately operated by percutaneous Kirschner wire fixation combined with external fixators. He was able to walk with full weight bearing without any assistance at the end of the first postoperative year. Early aggressive debridement and irrigation followed by fixation with percutaneous Kirschner wires and external fixator can supply bony alignment in open comminuted calcaneal fractures associated with concomitant lower extremity injuries and should be considered for the healthy and active patients before primary arthrodesis

Crizotinib efficacy and safety in patients with advanced NSCLC harboring MET alterations: A real-life data of Turkish Oncology Group

Crizotinib is a multikinase inhibitor, effective in non-small cell lung cancer (NSCLC) harboring mesenchymal-epidermal transition (MET) alterations. Although small prospective studies showed efficacy and safety of crizotinib in NSCLC with MET alterations, there is limited real-life data. Aim of this study is to investigate real-life efficacy and safety of crizotinib in patients with advanced NSCLC harboring MET alterations. This was a retrospective, multicenter (17 centers) study of Turkish Oncology Group. Patients' demographic, histological data, treatment, response rates, survival outcomes, and toxicity data were collected. Outcomes were presented for the study population and compared between MET alteration types. Total of 62 patients were included with a median age of 58.5 (range, 26-78). Major histological type was adenocarcinoma, and 3 patients (4.8%) had sarcomatoid component. The most common MET analyzing method was next generation sequencing (90.3%). MET amplification and mutation frequencies were 53.2% (n = 33) and 46.8% (n = 29), respectively. Overall response rate and disease control rate were 56.5% and 74.2% in whole study population, respectively. Median progression free survival (PFS) was 7.2 months (95% confidence interval [CI]: 3.8-10.5), and median overall survival (OS) was 18.7 months (95% CI: 13.7-23.7), regardless of treatment line. Median PFS was 6.1 months (95% CI: 5.6-6.4) for patients with MET amplification, whereas 14.3 months (95% CI: 6.7-21.7) for patients with MET mutation (P = .217). Median PFS was significantly longer in patients who have never smoked (P = .040), have good performance score (P < .001), and responded to the treatment (P < .001). OS was significantly longer in patients with MET mutation (25.6 months, 95% CI: 15.9-35.3) compared to the patients with MET amplification (11.0 months; 95% CI: 5.2-16.8) (P = .049). In never-smokers, median OS was longer than smoker patients (25.6 months [95% CI: 11.8-39.3] vs 16.5 months [95% CI: 9.3-23.6]; P = .049). The most common adverse effects were fatigue (50%), peripheral edema (21%), nausea (29%) and diarrhea (19.4%). Grade 3 or 4 adverse effects were observed in 6.5% of the patients. This real-life data confirms efficacy and safety of crizotinib in the treatment of advanced NSCLC harboring MET alteration

Argüman Yapısı ve Görünümün Adlaştırma Süreçlerindeki Rolü

Proje Türkçe türetimsel biçimbiliminde (İng. derivational morphology) yer alan adlaştırma süreçlerinin (İng. nominalization) detaylı bir analizini yapmak; (ii) bu analiz temelinde argüman yapısı (İng. argument structure) ve görünümün (İng. aspect) adlaştırma süreçlerindeki rolü üzerine literatürde devam etmekte olan tartışmalara katkı sunmak; ve (iii) berimsel biçimbilim çalışmalarına güvenilir insan yapısı bir veri tabanı oluşturmak amacıyla önerilmektedir. Bu amaçlara ulaşılmasında kuramsal çalışmanın yanı sıra iki işaretleyicinin eğitilerek veri işaretlemesi ve bu işaretlemelerin uyumluluğun karşılaştırılması, ve gerek duyulduğu takdirde bir takım adlaştırma süreçlerinin üretimselliğinin test edilmesi amacıyla web-tabanlı anket çalışmaları uygulanacaktır

The effects of oviductal cell co-culture and different gas mixtures on the development of bovine embryos in vitro

The objective of the current study was to investigate the effects of the addition of oviduct co-culture to synthetic oviduct fluid (SOF) and Menezo B2 media used in an in vitro study of cows, and the effects of different gas atmospheres (5% CO2 or 5% CO2, 5% O-2, and 90% N-2) on in vitro cultures. Oocytes obtained through aspiration from the ovaries of slaughtered Holstein cows were washed and cultured within a TCM-199 maturation medium at 38.8 degrees C for 23 h. Then the matured oocytes and thawed semen, prepared in accordance with the swim-up method, were incubated for fertilization within in vitro fertilization (IVF)-Tyrode's albumin lactate pyruvate (TALP) medium with an atmosphere including the combination of 5% CO2, 5% O-2, and 90% N-2 gas, at 38.8 degrees C for 18-24 h. Fertilized oocytes were distributed into 3 main groups: Group I: B2 (5% CO2), Group II: B2 medium (5% CO2, 5% O-2, and 90% N-2), and Group III: SOF (5% CO2, 5% O-2, and 90% N-2), and each group was divided into 2 subgroups, with and without oviduct co-culture cells, and were cultured for 9 days. The percentage of embryos that reached the blastocyst stage was 34.0%, 20.0%, and 32.3% in the co-culture group and 26.7% and 23.3% in the without co-culture group, respectively. Group III showed the highest development of expanded blastocyst stage (P < 0.01). In conclusion, the addition of co-culture to B2 (5% CO2 atmosphere) and SOF (5% CO2, 5% O-2, and 90% N-2 atmosphere) media increased the rate of transferable embryos