Normocalcemic brown tumor mimicking metastatic bone disease: report of a case

Kemik sintigrafisi oldukça yaygın kullanılan bir tarama yöntemidir. Brown tümör ilerlemis hiperparatiroidinin oldukça nadir görülen bir bulgusudur. Primer hipertroidi, hiperkalsemi ve hipofosfatemi ile seyreden bir hastalıktır ve sintigrafik görüntülemede metastatik kemik hastalıgını taklit edebilir. Biz bu yazımızda yaygın kemik agrısı yakınması ile basvuran ve çekilen tüm vücut kemik sintigrafisinde kostalarda ve sol femur proksimalinde metastatik olarak degerlendirilen aktivite artısları saptanan 65 yasında bir kadın hastayı sunuyoruz. Ancak, yapılan tetkiklerinde serum kalsiyum ve fosforu normal sınırlardaydı. Paratiroid sintigrafisinde sag alt bölgede paratiroid adenomu ile uyumlu artmıs tutulum saptandı ve paratiroidektomi yapıldı.Bone scintigraphy is a commonly used screening tool in medicine. Brown tumor can be a rare skeletal manifestation of advanced hyperparathyroidism. Primer hyperparathyroidism presents with hypercalcaemia and hypophosphatemia and it can mimic metastatic bone disease. We described a 65-year-old woman who has referred for generalized pain exacerbating on movement and increased uptake in the ribs, proximal of the left femur neck suggestive of metastatic lesions by whole body bone scintigraphy. However, serum calcium and phosphorus levels were normal. Parathyroid scintigraphy revealed extensive uptake in the right lower neck regions consistent with parathyroid adenoma. Parathyroidectomy was performed

Comparison of bioelectrical impedance and the other methods used for diagnosis of obesity

Several methods are being used for the diagnostic evaluation of obesity. Body mass index (BMI) is the most commonly used method. Various other methods such as waist circumference, waist/hip ratio and skinfold thickness measurements are also of use. Bioelectrical impedance is an easy and non-invasive method that provides a reliable estimate of total body fat and fat free mass. The purpose of this study was to make a comparative evaluation of these various methods. 140 patients (age: 41.8±11.8 yr) admitted to the hospital for obesity were included in the study. Body mass index, waist circumference, waist/hip ratio and skinfold thickness measurements at biceps, triceps and subscapular regions were evaluated. Body fat ratio and fat mass were measured with bioelectrical impedance. Mean body mass index was 35.5±5.4 kg/m . Sum of skinfold thickness of triceps and subscapular region was found to be increased in 116 patients (82.8%) and normal in 24 patients (17.1%). While the waist/hip ratio was found to be increased in 71 patients (50.7%); in 8 patients (5.7%) were within normal range, 22 patients (15.7%) showed increased risk and 107 patients (76.4%) had high risk according to weist circumference. Body fat ratio with bioelectric impedance was evaluated as normal in 8 patients (5.7%), borderline in 9 patients (6.4%) and high in 123 patients (87.9%). Body fat ratio with bioelectric impedance correlated with body mass index, waist circumference and skinfold thickness (p0.05). We conclude that body mass index and bioelectric impedance are important methods in the diagnosis of obesity, and the use of waist circumference in addition to these methods to evaluate the abdominal obesity may also be useful.Obezitenin değerlendirilmesinde çeşitli yöntemler kullanılmaktadır. En yaygın kullanılan yöntem vücut kitle indeksidir, ayrıca, bel çevresi, bel/kalça oranı ve deri kıvrımı kalınlıkları ölçümü gibi çeşitli yöntemler de kullanılmaktadır. Biyoelektrik impedans yöntemi de uygulanması kolay, invaziv olmayan bir yöntemdir ve yağ kitlesi ve yağsız kitlenin değerlendirilmesini sağlar. Bu çalışmada obezite tanısında kullanılan yöntemlerin karşılaştırılması amaçlanmıştır. Kilo fazlalığı nedeniyle başvuran 140 hasta (ortalama yaş: 41.8±11.8 yıl) çalışmaya alındı. Hastaların vücut kitle indeksleri (VKı) hesaplandı, biseps, triseps ve skapula altı bölgelerinde deri kıvrımı kalınlıkları, bel ve kalça çevreleri ölçüldü, bel/kalça oranları hesaplandı. Biyoelektrik impedans yöntemi ile vücudun yağ oranı ve yağ kitlesi ölçüldü. Vücut kitle indeksi ortalama 35.5±5.4 kg/m bulundu.Triseps ve skapula altı ölçümlerinin toplamı 116 hastada (%82.8) artmış, 24 hastada (%17.1) normal bulundu. Bel/kalça oranı hastaların 71'inde (%50.7) artmış bulunurken, bel çevresi 8 hastada (%5.7) normal, 22 hastada (%15.7) artmış risk düzeyinde, 107 hastada ise (%76.4) yüksek risk düzeyinde bulundu. Biyoelektrik impedans yöntemi ile elde edilen vücut yağ oranı 8 hastada (%5.7) normal, 9 hastada (%6.4) sınırda yüksek ve 123 hastada (%87.9) yüksek bulundu. Biyoelektrik impedans ile yağ oranı ölçümü sonuçlarının VKı ile, bel çevresi ile ve deri kıvrımı kalınlıkları ile korele olduğu (p<0.001), bel kalça oranı ile ise korele olmadığı (p>0.05) saptandı. Çalışmada elde edilen veriler, vücut kitle indeksi ve biyoelektrik impedans yöntemlerinin obezite tanısında değerli olduğunu, abdominal obeziteyi değerlendirmek için de bel çevresi ölçümünün bu yöntemlerle birlikte kullanılmasının yararlı olacağını düşündürmektedir

Histopathologic Evaluation of Nonalcoholic Fatty Liver Disease in Hypothyroidism-Induced Rats

It is speculated that thyroid hormones may be involved in nonalcoholic fatty liver disease (NAFLD) pathogenesis. A literature scan, however, demonstrated conflicting results from studies investigating the relationship between hypothyroidism and NAFLD. Therefore, our study aims to evaluate NAFLD, from the histopathologic perspective, in hypothyroidism-induced rats. Wistar rats were divided into 2 groups: the experimental group consumed water containing methimazole 0.025% (MMI, Sigma, USA) for 12 weeks and the control group consumed tap water. At the end of week 12, serum glucose, ALT, AST, triglyceride, HDL, LDL, TSH, fT4, fT3, visfatin, and insulin assays were performed. Sections were stained with hematoxylin-eosin and &quot;Oil Red-O&quot; for histopathologic examination of the livers. In our study, we detected mild hepatosteatosis in all hypothyroidism-induced rats. There was statistically significant difference with respect to obesity between the two groups ( &lt; 0.001). The mean fasting blood glucose was 126.25 ± 23.4 mg/dL in hypothyroidism-induced group and 102.63 ± 15.51 mg/dL in the control group, with a statistically significant difference between the groups ( = 0.032). The two groups did not differ statistically significantly with respect to visfatin levels ( &gt; 0.05). In conclusion, we found that hypothyroidism-induced rats had mild hepatosteatosis as opposed to the control group histopathologically. Our study indicates that hypothyroidism can cause NAFLD

Histopathologic Evaluation of Nonalcoholic Fatty Liver Disease in Hypothyroidism-Induced Rats

It is speculated that thyroid hormones may be involved in nonalcoholic fatty liver disease (NAFLD) pathogenesis. A literature scan, however, demonstrated conflicting results from studies investigating the relationship between hypothyroidism and NAFLD. Therefore, our study aims to evaluate NAFLD, from the histopathologic perspective, in hypothyroidism-induced rats. Wistar rats were divided into 2 groups: the experimental group consumed water containing methimazole 0.025% (MMI, Sigma, USA) for 12 weeks and the control group consumed tap water. At the end of week 12, serum glucose, ALT, AST, triglyceride, HDL, LDL, TSH, fT4, fT3, visfatin, and insulin assays were performed. Sections were stained with hematoxylin-eosin and “Oil Red-O” for histopathologic examination of the livers. In our study, we detected mild hepatosteatosis in all hypothyroidism-induced rats. There was statistically significant difference with respect to obesity between the two groups (p<0.001). The mean fasting blood glucose was 126.25 ± 23.4 mg/dL in hypothyroidism-induced group and 102.63 ± 15.51 mg/dL in the control group, with a statistically significant difference between the groups (p=0.032). The two groups did not differ statistically significantly with respect to visfatin levels (p>0.05). In conclusion, we found that hypothyroidism-induced rats had mild hepatosteatosis as opposed to the control group histopathologically. Our study indicates that hypothyroidism can cause NAFLD

Serological diagnosis of toxoplasmosis and determination of seroprevalence of anti-Toxoplasma gondii antibodies in cattle in Bursa province

Bu çalışmayla Bursa bölgesindeki sığırlarda toxoplasmosisin serolojik tanısı ve anti-Toxoplasma gondii antikor seroprevalansının belirlenmesi amaçlandı. Çalışmanın materyalini Bursa ve çevresindeki altı farklı ilçeden rastgele seçilen 2 ay-5 yaşlı, Holstein ırkı 200 adet sağlıklı sığır oluşturdu. Tüm hayvanların klinik muayeneleri yapıldı ve kan örnekleri toplandı.An-T.T.Toxsoplasma gondii antikorları Sabin Feldman tekniği ile analiz edildi. Çalışmada 200 sığırın 146'smda (%73) anti-T. gondii antikorları saptanırken 54 (%27) sığırın seronegatif olduğu belirlendi. En yüksek seropozitiflik oranı Keleş (%86.2) en düşük oran ise Merkez ilçede (%63) belirlendi. Anti -T. gondii antikor seroprevalansının 0-1 yaş grubunda diğer yaş gruplarından daha yüksek oranda (%80.3) olduğu saptandı. Seropozitif ve seronegatif sığırların hematolojik muayenelerinde bir farklılık saptanmadı. Sonuç olarak, bu çalışmada Bursa bölgesindeki sığırlarda toxoplasmosis seroprevalansının yüksek düzeyde olduğu ve hastalığa gençlerin daha duyarlı oldukları saptandı. Halk sağlığı açısından önemli bir enfeksiyon olan toxoplasmosise karşı profilaktif önlemlerin alınmasının gerekli olduğu kanısına varıldı.Serological diagnosis of toxoplasmosis and determination of seroprevalence of anti- Toxoplasma gondii antibodies in cattle in Bursa province were aimed in this study. The material of the study was consisted of randomly selected twohundred healthy Holstein cattle aged 2 month - 5 year from six different districts in Bursa province. Cli&shy;nical examinations were performed and blood samples were collected from all cattle. Anti-Toxoplasma gondii an&shy;tibodies were analyzed with Sabin Feldman test. Anti - T. gondii antibodies were detected in 146 (73%) of 200 cattle and 54 (27%) cattle were found seronegative. Higher seropositivity was observed in Keles (86.2%) whereas lower se-ropositivity was found in Central district (63%). No difference was detected in hematological analysis of seropositive and seronegative cattle. As a result, it was determined that seroprevalance of toxoplasmosis was high in cattle in Bursa region and it was found that young cattle were more susceptible to ihfection in this study. It was concluded that prophylactic procedures must be performed in cattle against toxoplasmosis which is an important zoonotic infection for public health

Treatment of Faun-Tail Naevus with Intense Pulsed Light

Background: Faun tail is a rare cutaneous marker of spinal dysraphism. This neurological abnormality may lead to difficulties such as severe pain and burning sensations in treatment of hypertrichosis of faun tail with laser or laser-like devices. Objective: We evaluated outcomes of an intense pulsed light source in two patients with faun tail. Methods: The Lumina intense pulsed light system [650-nm handpiece (550-1100 nm)] was used for the treatment. Magnetic resonance imaging and neurological examination were done. Results: Tethered cord syndrome was detected as a neurological abnormality. The patients were treated with an energy fluence of 18-26 J/cm(2), pulse sequencing of 3 to 4, and a delay time of 20-35 ms. Local anesthesia was applied in one patient during treatment for severe pain sensation. A mean of 85% hair reduction was achieved. Conclusion: A good cosmetic result with intense pulsed light treatment was achieved in the patients with faun tail. Local anesthesia may be required before treatment of faun tail with laser or laser-like systems due to associated neurological abnormalities