Predictors of disease worsening defined by progression of organ damage in diffuse systemic sclerosis: a European Scleroderma Trials and Research (EUSTAR) analysis.

Objectives Mortality and worsening of organ function are desirable endpoints for clinical trials in systemic sclerosis (SSc). The aim of this study was to identify factors that allow enrichment of patients with these endpoints, in a population of patients from the European Scleroderma Trials and Research group database. Methods Inclusion criteria were diagnosis of diffuse SSc and follow-up over 12\ub13 months. Disease worsening/organ progression was fulfilled if any of the following events occurred: new renal crisis; decrease of lung or heart function; new echocardiography-suspected pulmonary hypertension or death. In total, 42 clinical parameters were chosen as predictors for the analysis by using (1) imputation of missing data on the basis of multivariate imputation and (2) least absolute shrinkage and selection operator regression. Results Of 1451 patients meeting the inclusion criteria, 706 had complete data on outcome parameters and were included in the analysis. Of the 42 outcome predictors, eight remained in the final regression model. There was substantial evidence for a strong association between disease progression and age, active digital ulcer (DU), lung fibrosis, muscle weakness and elevated C-reactive protein (CRP) level. Active DU, CRP elevation, lung fibrosis and muscle weakness were also associated with a significantly shorter time to disease progression. A bootstrap validation step with 10 000 repetitions successfully validated the model. Conclusions The use of the predictive factors presented here could enable cohort enrichment with patients at risk for overall disease worsening in SSc clinical trial

Phasmoiden und Forficuliden von Java, den Kleinen Sundainseln und Nordaustralien

Volume: 41Start Page: 525End Page: 54

cber die Tridactyloidea (Saltatoria, Insecta) in den Sammlungen des Museums f\ufcr Naturgeschichte der Stadt Genf

Volume: 81Start Page: 1027End Page: 107

A new pygmy mole grasshopper from California and Baja California, Mexico (Orthoptera: Tridactylidae)

Volume: 61Start Page: 139End Page: 14

Ueber einige von H. Overbeck 1933/34 auf Java gesammelte Insekten

Volume: 79Start Page: 64End Page: 7

Eyewitness identification: Simulating the "weapon effect."

Investigated the effect of weapons on eyewitness recall and recognition in 86 university students, using an experimental paradigm in which a syringe served as weapon simulation. Ss were approached by an experimenter who was either holding a syringe or a pen and either did or did not threaten to administer an injection. Exposure to the syringe greatly decreased lineup recognition, while enhancing the accuracy of recall for hand cues. Threat of injection did not interact with the syringe manipulation. Investigation of individual differences indicated greater accuracy of recall for facial details among Ss with less fear of injections and greater cognitive abilitie

Ten instars in the leprous grasshopper Phymateus leprosus (Fabricius, 1793) (Caelifera: Pyrgomorphidae): Maximum number recorded in the Acridoidea

Volume: 56Start Page: 17End Page: 2

Dactyloa Biporcata Wiegmann, 1834 (Currently Anolis Biporcatus) And Anolis Petersii Bocourt, 1873 (Reptilia, Sauria): Proposed Conservation Of The Specific Names And Designation Of A Neotype For A. Biporcatus

Volume: 58Start Page: 122End Page: 12

Publication strategy for junior researchers: Quantity vs. quality, the first authorship and the optimal number of authors

A good publication record is one of the most important prerequisites of a successful academic career in IS. Despite the weight hiring and promotion committees place on it, the definition of a "good publication record" especially for junior researchers remains unclear. Indeed, is it better to have one A-publication or three B-publications? Does being the third author on an A-publication have a bigger weight than being the first author on a B-publication? Should one strive to publish with as few coauthors as possible to demonstrate that one is capable of independent work? Facing these ambiguities, young researchers are increasingly asking themselves about the choices they make with regard to their publication strategy. Equally, academic mentors have a strong interest in correctly setting incentives of their young prot\ue9g\ue9s. If unaddressed, uncertainty regarding these issues is bound to interfere with the quality of the IS research and scholars\u27 job and life satisfaction. This panel proposal aims to offer a forum for discussion and clarification on these problematic issues. Specifically, the following topics will be raised: quantity vs. quality, value of the first authorship and optimal number of authors