Combination therapy analysis of ezetimibe and statins in Chinese patients with acute coronary syndrome and type 2 diabetes

Background Dyslipidemia management situation in Chinese patients with high risk and very high risk has been demonstrated very low, despite the wide use of statins. The effects and safety of the combined treatment of ezetimibe (EZ) and statins in Chinese patients with acute coronary syndrome (ACS) and type 2 diabetes mellitus (T2DM) remain unknown. Methods Chinese Patients with ACS and T2DM were divided into the statins group (n = 40) and the combination group of EZ and statins (n = 44). In order to evaluate the clinical effects on lipids- lowering, systemic inflammation response and clinical safety, the follow-up of all patients was carried out at day 7th and 30th after treatment. Results The level of low-density lipoprotein cholesterol (LDL-C) in combination group and statins group was 1.87 ± 0.42 and 2.18 ± 0.58 mmol/L at day 7th, 1.51 ± 0.29 and 1.94 ± 0.49 mmol/L at day 30th, respectively. The control rates of LDL-C level in the combination group and the statins group were 77% and 45% at day 30th, respectively. There was no significant improvement on high-density lipoprotein cholesterol (HDL-C) level during follow-up. The triglyceride (TG) levels were significantly reduced in both groups, while no obvious difference was observed between two groups. No significant difference on serum high- sensitivity C-reactive protein (hs-CRP) level between two groups was observed. Moreover, we did not observe any significant correlation between serum lipids levels and serum hs-CRP level during follow-up. The liver dysfunction and muscle related side effects (MRSE), creatine kinase (CK) and myopathy were not observed in both groups. Conclusion Our study demonstrated that it is feasible to initiate combination therapy during acute phase for Chinese patients with ACS and T2DM, which can bring more significant effect on LDL-C-lowering and improve the control rate of LDL-C level with good safety

Influence of Floating Monitoring Platform Structure on the Hydrostatic Characteristics

According to the environment and work styles, the underwater monitoring devices can be divided into three type, fixed monitoring device, the floating monitoring device and mobile monitoring device. Floating monitoring platform is a new type of monitoring device of the floating monitoring device, which is mainly used for underwater video monitoring of pool. as the floating platform monitoring in water motion and hydrostatic characteristics are closely related, the influent of counterweight, weight distance and floating body diameter of the structure parameters on its hydrostatic characteristics and the natural periods for roll, pitch and heave should be considered, In this work, the floating body diameter influent most, the counterweight followed, and the structure parameters have different influence on the natural periods for roll, pitch and heave , it need to be analyzed according to the concrete structure parameters

Influence of Floating Monitoring Platform Structure on the Hydrostatic Characteristics

According to the environment and work styles, the underwater monitoring devices can be divided into three type, fixed monitoring device, the floating monitoring device and mobile monitoring device. Floating monitoring platform is a new type of monitoring device of the floating monitoring device, which is mainly used for underwater video monitoring of pool. as the floating platform monitoring in water motion and hydrostatic characteristics are closely related, the influent of counterweight, weight distance and floating body diameter of the structure parameters on its hydrostatic characteristics and the natural periods for roll, pitch and heave should be considered, In this work, the floating body diameter influent most, the counterweight followed, and the structure parameters have different influence on the natural periods for roll, pitch and heave , it need to be analyzed according to the concrete structure parameters

Ultra-short contact time conversion of chloromethane to olefins over pre-coked SAPO-34: direct insight into the primary conversion with coke deposition

Hydrocarbon species trapped in the catalyst that work as the reaction center and govern the conversion and product selectivity of chloromethane transformation were revealed by a very efficient home-made ultra-short contact time pulse reaction system over pre-coked SAPO-34