New constraints on a triaxial model of the Galaxy

We determine the values of parameters of an N-body model for the Galaxy developed by Fux via comparison with an unbiased, homogeneous sample of OH/IR stars. Via Monte-Carlo simulation, we find the plausibilities of the best-fitting models, as well as their errors. The parameters that are constrained best by these projected data are the total mass of the model and the viewing angle of the central Bar, although the distribution of the latter has multiple maxima. The best model has a viewing angle of 44 degrees, semi-major axis of 2.5 kpc, a bar mass of 1.7E10 solar masses and a tangential velocity of the local standard of rest of 171 km/s . We argue that the lower values that are commonly found from stellar data for the viewing angle (around 25 degrees) arise when too few coordinates are available, when the longitude range is too narrow or when low latitudes are excluded from the fit. The new constraints on the viewing angle of the galactic Bar from stellar line-of-sight velocities decrease further the ability of the Bar's distribution to account for the observed micro-lensing optical depth toward Baade's window : our model reproduces only half the observed value. The signal of triaxiality diminishes quickly with increasing latitude, fading within approximately one scaleheight. This suggests that Baade's window is not a very appropriate region to sample Bar properties.Comment: 10 pages, 8 figures, TeX, accepted for publication in MNRA

The role of computer engineering and new information technologies in developing innovations for science and education

In this article we are talking about the role of information technologies in improving the efficiency of labor in the scientific and educational spheres of lifeВ данной статье речь идет о роли информационных технологий в повышении эффективности труда в научной и образовательной сферах жизнедеятельност

Is Galactic Structure Compatible with Microlensing Data?

We generalize to elliptical models the argument of Kuijken (1997), which connects the microlensing optical depth towards the Galactic bulge to the Galactic rotation curve. When applied to the latest value from the MACHO collaboration for the optical depth for microlensing of bulge sources, the argument implies that the Galactic bar cannot plausibly reconcile the measured values of the optical depth, the rotation curve and the local mass density. Either there is a problem with the interpretation of the microlensing data, or our line of sight to the Galactic centre is highly atypical in that it passes through a massive structure that wraps only a small distance around the Galactic centre.Comment: Submitted to ApJ Letters. 8 pages LaTeX, 3 figures. Corrected error in description of microlensing observation

Tracing out the Northern Tidal Stream of the Sagittarius Dwarf Spheoridal Galaxy

The main aim of this paper is to report two new detections of tidal debris in the northern stream of the Sagittarius dwarf galaxy located at 45 arcdeg and 55 arcdeg from the center of galaxy. Our observational approach is based on deep color-magnitude diagrams, that provides accurate distances, surface brightness and the properties of stellar population of the studied region of this tidal stream. The derived distances for these tidal debris wraps are 45 kpc and 54 kpc respectively.We also confirm these detections with numerical simulations of the Sagittarius dwarf plus the Milky Way. The model reproduces the present position and velocity of the Sagittarius main body and presents a long tidal stream formed by tidal interaction with the Milky Way potential. This model is also in good agreement with the available observations of the Sagittarius tidal stream. We also present a method for estimating the shape of the Milky Way halo potential using numerical simulations. From our simulations we obtain an oblateness of the Milky Way dark halo potential of 0.85, using the current database of distances and radial velocities of the Sagittarius tidal stream. The color-magnitude diagram of the apocenter of Sagittarius shows that this region of the stream shares the complex star formation history observed in the main body of the galaxy. We present the first evidence for a gradient in the stellar population along the stream, possibly correlated with its different pericenter passages. (abridged)Comment: 43 pages (including 15 figures; for high resolution color figures, please contact [email protected]). Submitted to Ap

The Pattern Speed of the Galactic Bar

Most late-type stars in the solar neighborhood have velocities similar to the local standard of rest (LSR), but there is a clearly separated secondary component corresponding to a slower rotation and a mean outward motion. Detailed simulations of the response of a stellar disk to a central bar show that such a bi-modality is expected from outer-Lindblad resonant scattering. When constraining the run of the rotation curve by the proper motion of Sgr A* and the terminal gas velocities, the value observed for the rotation velocity separating the two components results in a value of (53+/-3)km/s/kpc for the pattern speed of the bar, only weakly dependent on the precise values for Ro and bar angle phi.Comment: 5 pages LaTeX, 2 Figs, accepted for publication in ApJ Letter

Efficacy and safety of secukinumab for the treatment of severe ABCA12 deficiency‐related ichthyosis in a child

Summary Background Patients with severe autosomal recessive congenital ichthyosis (ARCI) show a T helper 17/interleukin 17 (Th17/IL17) skewing in their skin and serum, resembling the inflammatory profile of psoriatic patients. Secukinumab, an IL‐17A inhibitor, has shown clinical efficacy in patients with moderate‐to‐severe plaque psoriasis. Aims To test the clinical efficacy and safety of secukinumab in a paediatric patient with ATP‐binding cassette subfamily A member 12 deficiency‐related severe erythrodermic ARCI. Materials & Methods 6‐months therapeutic trial. During the first 4‐weeks induction period, the patient received weekly subcutaneous injections of 150 mg secukinumab (five injections in total). During the following 20‐weeks maintenance period, the patient was given a subcutaneous injection of 150 mg secukinumab every 4 weeks. Result & Discussion After the 6‐months therapy period, there was a 48% reduction from the baseline Ichthyosis‐Area‐Severity‐Index (‐Erythema/‐Scaling) score. The treatment was well tolerated. Moreover, cytokine analysis revealed a reduction of keratinocyte‐derived proinflammatory cytokines and an abrogation of Th17‐skewing during therapy. Conclusion Further studies are needed to evaluate the effects of the use of IL‐17A inhibition in ARCI patients