Temperature of a gray body most closely fit- ting the solar extraterrestrial spectrum

Temperature measurements of black body most closely fitting solar extraterrestrial spectru

System and method for responding to ground and flight system malfunctions

A system for on-board anomaly resolution for a vehicle has a data repository. The data repository stores data related to different systems, subsystems, and components of the vehicle. The data stored is encoded in a tree-based structure. A query engine is coupled to the data repository. The query engine provides a user and automated interface and provides contextual query to the data repository. An inference engine is coupled to the query engine. The inference engine compares current anomaly data to contextual data stored in the data repository using inference rules. The inference engine generates a potential solution to the current anomaly by referencing the data stored in the data repository

Non-linear optical imaging – Introduction and pharmaceutical applications

Nonlinear optical imaging is an emerging technology with much potential in pharmaceutical analysis. The technique encompasses a range of optical phenomena, including coherent anti-Stokes Raman scattering (CARS), second harmonic generation (SHG), and twophoton excited fluorescence (TPEF). The combined potential of these phenomena for pharmaceutical imaging includes chemical and solidstate specificity, high optical spatial and temporal resolution, nondestructive and non-contact analysis, no requirement for labels, and the compatibility with imaging in aqueous and biological environments. In this article, the theory and practical aspects of nonlinear imaging are briefly introduced and pharmaceutical and biopharmaceutical applications are considered. These include material and dosage form characterization, drug release, and drug and nanoparticle distribution in tissues and within live cells. The advantages and disadvantages of the technique in the context of these analyses are also discussed

Targeted monitoring for human pharmaceuticals in vulnerable source and final waters

A range of pharmaceuticals has been detected in soils, surface waters and groundwaters across the world. While the reported concentrations are generally low (i.e. sub μg l-1 in surface waters), the substances have been observed throughout the year across a variety of hydrological, climatic and land-use settings. As a result, questions have been raised over the potential for pharmaceuticals in surface waters to enter drinking water supplies and to affect consumers. In a previous Drinking Water Inspectorate (DWI) funded study, results from a simple exposure model were used alongside information on therapeutic doses of pharmaceuticals to identify pharmaceuticals that are likely to be of most concern in UK drinking water sources. However, this previous study was entirely desk-based and did not involve any experimental measurements of pharmaceutical concentrations. The current study was therefore performed to generate actual measurements on the occurrence of pharmaceuticals in source and treated waters in England. The study considered a range of pharmaceutical compounds and their metabolites that have either a) high predicted exposure concentrations; b) toxicological concerns; or c) a low predicted exposure to therapeutic dose ratio. An illicit drug and its major metabolite were also investigated. The study compounds (in total 17) covered a range of chemical classes and varied in terms of their physico-chemical properties. The study was done at four sites where concentrations in source water at the drinking water treatment abstraction point were predicted to be some of the greatest in England. The study therefore is likely to provide a ‘worst case’ assessment of potential human exposure to pharmaceuticals in drinking water in England and Wales. Ten of the 17 study compounds were detected in untreated source waters at sub-μg/l concentrations. Six of these compounds (namely, benzoylecgonine (a metabolite of cocaine), caffeine, carbamazepine (an antiepileptic medicine), carbamazepine epoxide (a metabolite of carbamazepine), ibuprofen and naproxen (both non-steroidal anti-inflammatory drugs) were also detected in treated drinking water. With the exception of carbamazepine epoxide, concentrations in treated drinking water were generally significantly lower than in source water. Even though England is a densely populated country and in some regions there is limited dilution of wastewater effluents, these observations, made at sites that were predicted to have some of the highest concentrations of pharmaceuticals in England and Wales, are in line with results from similar studies performed in other countries. Comparison of measured concentrations of the study compounds in drinking waters with information on therapeutic doses demonstrated that levels of these compounds in drinking water in England are many orders of magnitude lower than levels that are given to patients therapeutically. It would therefore appear that the low or non-detectable levels of pharmaceuticals and illicit drugs present in drinking waters in England and Wales do not pose an appreciable risk to human health

Ambient air pollution and adverse birth outcomes: A review of underlying mechanisms

Epidemiological data provide varying degrees of evidence for associations between prenatal exposure to ambient air pollutants and adverse birth outcomes (suboptimal measures of fetal growth, preterm birth and stillbirth). To assess further certainty of effects, this review examines the experimental literature base to identify mechanisms by which air pollution (particulate matter, nitrogen dioxide and ozone) could cause adverse effects on the developing fetus. It likely that this environmental insult impacts multiple biological pathways important for sustaining a healthy pregnancy, depending upon the composition of the pollutant mixture and the exposure window owing to changes in physiologic maturity of the placenta, its circulations and the fetus as pregnancy ensues. The current body of evidence indicates that the placenta is a target tissue, impacted by a variety of critical processes including nitrosative/oxidative stress, inflammation, endocrine disruption, epigenetic changes, as well as vascular dysregulation of the maternal‐fetal unit. All of the above can disturb placental function and, as a consequence, could contribute to compromised fetal growth as well increasing the risk of stillbirth. Furthermore, given that there is often an increased inflammatory response associated with preterm labour, inflammation is a plausible mechanism mediating the effects of air pollution on premature delivery. In the light of increased urbanisation and an ever‐changing climate, both of which increase ambient air pollution and negatively affect vulnerable populations such as pregnant individuals, it is hoped that the collective evidence may contribute to decisions taken to strengthen air quality policies, reductions in exposure to air pollution and subsequent improvements in the health of those not yet born

On-farm Experiments with Millet in Niger: Crop Establishment, Yield Loss Factors and Economic Analysis

Results of farm-level experiments with pearl millet are reported from four villages in semi-arid Niger in 1982 and 1983. Crop establishment, yield loss factors (insects, diseases, striga) and economics of new practices were studied in a randomized design which included density, fertility, cultivar, and intercropping with cowpea as treatments. Improved cultivars did not establish significantly better than local ones, but fertilizer occasionally improved establishment. Incidence of yield loss factors was low, and only small effects of cultivar and fertilizer were seen. Fertilizer increased grain yields of the local cultivar by as much as 153%. The use of fertilizer and improved cultivars increased grain yields by as much as 171% over an unfertilized local millet. Even without government subsidies, fertilizer use was profitable for 56% of farmers on all cultivars. In general, fertilizers and improved cultivars had a small positive impact on profitability, with little adverse impact on grain yield variability, so that they could be recommended to farmers with some prospect of success. The intercropping treatment failed in both years, and would have to be modified before extensio

Effectiveness of Virtual Reality Simulations for Civilian, Ab Initio Pilot Training

Aviation training in the immersive Virtual Reality (VR) world has the power to overcome physical constraints, presenting cues and stimuli that would not be available in flight, nor in a two-dimensional (2D) environment. This gives VR powerful potential as a simulation tool for learning complex skills and maneuvers in the cockpit. This study evaluated the effectiveness of VR simulations as compared to traditional 2D desktop simulations in teaching maneuvers and skills to ab initio (inexperienced) civilian pilot trainees. This quasi-experimental project involved 17 freshman pilot students in an experimental college course at a private university campus in the fall semester of 2020. The participants were split into two sections: Section 1 completed CBT activities and simulations in 2D only, while Section 2 completed CBT activities in 2D and simulations in VR. Academic performance data was collected in the Canvas Learning Management System, broken down by understanding of a maneuver learned in a given lesson module. Descriptive statistics collected included quizzes, discussion board activity, and simulation completion scores. Paired samples t-tests compared perceived benefits of using the various course materials. Researchers also administered post-semester surveys to gather both qualitative and quantitative data, in which participants shared their perceptions of the course, preference for learning material type, and general feedback. Results indicated that students in both groups found the sims/tutorials and VR to be enjoyable and gratifying; the majority of students indicated that simulations were preferred over other learning materials. Early results indicate that although the students perceived that the simulations were beneficial, there were no significant differences in the final course scores or learning rates between those who utilized 2D sims as opposed to VR sims. The most important finding is that for ab initio pilots, VR simulations do not hinder learning mastery, as compared with traditional 2D desktop simulations