Fracture mechanics of pseudoelastic NiTi alloys: review of the research activities carried out at University of Calabria

This paper reports a brief review of the research activities on fracture mechanics of nickel-titaniumbased shape memory alloys carried out at University of Calabria. In fact, this class of metallic alloys show aunusual fracture response due to the reversible stress-induced and thermally phase transition mechanismsoccurring in the crack tip region as a consequence of the highly localized stresses. The paper illustrates the mainresults concerning numerical, analytical and experimental research activities carried out by using commercialNiTi based pseudoelastic alloys. Furthermore, the effect of several thermo-mechanical loading conditions onthe fracture properties of NiTi alloys are illustrated

Fracture mechanics of pseudoelastic NiTi alloys: review of the research activities carried out at University of Calabria

This paper reports a brief review of the research activities on fracture mechanics of nickel-titanium based shape memory alloys carried out at University of Calabria. In fact, this class of metallic alloys show a unusual fracture response due to the reversible stress-induced and thermally phase transition mechanisms occurring in the crack tip region as a consequence of the highly localized stresses. The paper illustrates the main results concerning numerical, analytical and experimental research activities carried out by using commercial NiTi based pseudoelastic alloys. Furthermore, the effect of several thermo-mechanical loading conditions on the fracture properties of NiTi alloys are illustrated

INFLUENZA DELLA SALDATURA LASER SUL COMPORTAMENTO A MEMORIA DI FORMA A DUE VIE DI UNA LEGA NiTi

Nel presente lavoro è riportato lo studio del comportamento funzionale di un giunto saldato in lega NiTi a memoria di forma. In particolare, sono stati analizzati gli effetti della saldatura laser Nd:YAG sul comportamento a memoria di forma a due vie (Two Way Shape Memory Effect, TWSME) di una lega Ni- 51 at.% Ti, attraverso un confronto sistematico con i risultati relativi al materiale non saldato. Il TWSME è stato indotto nel materiale attraverso un opportuna procedura di training, che consiste nella ripetizione di cicli termomeccanici; successivamente, sono stati misurati i cicli di isteresi (temperatura-deformazione) caratteristici del TWSME. Sono stati valutati, inoltre, gli effetti del numero di cicli di training e delle deformazioni plastiche, che si generano nel materiale durante il processo di training, sul comportamento a memoria di forma del materiale. I risultati mostrano come il comportamento funzionale, e in particolare il TWSME, sia parzialmente preservato nel materiale saldato che, comunque, presenta valori di deformazioni plastiche maggiori rispetto al materiale base

Ileo biliare: diagnosi e trattamento. Case report

Gli Autori presentano un caso di ileo biliare intermittente insorto per il passaggio di un grosso calcolo (oltre 4 cm di diametro) nel lume intestinale, attraverso una fistola colecistoduodenale. Viene sottolineata la peculiarità del caso clinico occorso alla loro osservazione per le caratteristiche della sintomatologia presentata dal paziente e per l’occasionalità dell’accertamento diagnostico avvenuto in corso di esame ecografico. La malattia, di non frequente riscontro e spesso diagnosticata in corso di interventi chirurgici in urgenza per occlusione intestinale, ha oggi un più precoce riconoscimento per la diffusione delle moderne tecniche di imaging. La sintomatologia può essere intermittente e, pur presentando i segni classici della occlusione intestinale, varia a seconda della sede dell’ostruzione. Una scelta terapeutica tempestiva endoscopica o chirurgica (open o laparoscopica) è destinata a ridurre la morbilità e la mortalità dei pazienti trattati in urgenza

Immunomodulatory Potential of Cannabidiol in Multiple Sclerosis: a Systematic Review

Multiple sclerosis (MS) is the most common chronic autoimmune disease of the central nervous system. Efficacy of treatments for MS is associated with risk of adverse effects, and effective and well-tolerated drugs remain a major unmet need. Cannabis (Cannabis sativa L., fam. Cannabaceae) and cannabinoids are popular among MS patients to treat spasticity and pain. Cannabinoids are endowed with remarkable immunomodulating properties, and in particular the non-psychotropic cannabinoid cannabidiol (CBD) is increasingly recognized as anti-inflammatory and immunosuppressive, nevertheless with excellent tolerability even at high doses. In this systematic review, we retrieved and critically evaluated available evidence regarding the immune and disease-modifying effects of CBD in experimental autoimmune encephalomyelitis (EAE) and in MS. Evidence in rodent models of EAE strongly supports CBD as effective, while clinical evidence is still limited and usually negative, due to paucity of studies and possibly to the use of suboptimal dosing regimens. Better characterization of targets acted upon by CBD in MS should be obtained in ex vivo/in vitro studies in human immune cells, and higher doses should be tested in well-designed clinical trials with clinically relevant efficacy endpoints. [Figure not available: see fulltext.

Numerical simulations and experimental measurements of the stress intensity factor in perforated plates

A numerical procedure, which combines two hybrid finite element formulations, was developed to analyse the stress intensity factors in cracked perforated plates with a periodic distribution of holes and square representative volume elements. The accuracy of the method in predicting the stress intensity factor was verified by a comparison with experimental measurements, carried out by a photoelasticity method, and by commercial finite element software. Several simulations were executed by varying both the crack length and the hole diameters, and the effects of the holes on the stress intensity factor are illustrated. The method shows high accuracy and efficiency, as small differences were observed when compared with the traditional finite element method, notwithstanding a strong reduction in degrees of freedom and mesh complexity