Molecular Beams

Contains reports on five research projects.Lincoln Laboratory (Purchase Order DDL B-00306)United States Air Force (Contract AF19(604)-7400)United States NavyUnited States Arm

RESOLUTION‐RETRIEVING SOURCE‐EFFECT COMPENSATION IN HOLOGRAPHY WITH EXTENDED SOURCES

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/69575/2/APPLAB-7-6-178-1.pd

Fourier-transform spectroscopy using holographic imaging without computing and with stationary interferometers

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/32013/1/0000055.pd

Molecular Beams

Contains reports on five research projects

Resolution-retrieving compensation of source effects by correlative reconstruction in high-resolution holography

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/31979/1/0000021.pd

Inter-species variation in colour perception

Inter-species variation in colour perception poses a serious problem for the view that colours are mind-independent properties. Given that colour perception varies so drastically across species, which species perceives colours as they really are? In this paper, I argue that all do. Specifically, I argue that members of different species perceive properties that are determinates of different, mutually compatible, determinables. This is an instance of a general selectionist strategy for dealing with cases of perceptual variation. According to selectionist views, objects simultaneously instantiate a plurality of colours, all of them genuinely mind-independent, and subjects select from amongst this plurality which colours they perceive. I contrast selectionist views with relationalist views that deny the mind-independence of colour, and consider some general objections to this strategy

Smart Gold Nanostructures for Light Mediated Cancer Theranostics: Combining Optical Diagnostics with Photothermal Therapy

This is the final version. Available from Wiley via the DOI in this record. Nanotheranostics, which combines optical multiplexed disease detection with therapeutic monitoring in a single modality, has the potential to propel the field of nanomedicine toward genuine personalized medicine. Currently employed mainstream modalities using gold nanoparticles (AuNPs) in diagnosis and treatment are limited by a lack of specificity and potential issues associated with systemic toxicity. Light-mediated nanotheranostics offers a relatively non-invasive alternative for cancer diagnosis and treatment by using AuNPs of specific shapes and sizes that absorb near infrared (NIR) light, inducing plasmon resonance for enhanced tumor detection and generating localized heat for tumor ablation. Over the last decade, significant progress has been made in the field of nanotheranostics, however the main biological and translational barriers to nanotheranostics leading to a new paradigm in anti-cancer nanomedicine stem from the molecular complexities of cancer and an incomplete mechanistic understanding of utilization of Au-NPs in living systems. This work provides a comprehensive overview on the biological, physical and translational barriers facing the development of nanotheranostics. It will also summarise the recent advances in engineering specific AuNPs, their unique characteristics and, importantly, tunability to achieve the desired optical/photothermal properties.Engineering and Physical Sciences Research Council (EPSRC

Microbiota-produced indole metabolites disrupt mitochondrial function and inhibit Cryptosporidium parvum growth

Cryptosporidiosis is a leading cause of life-threatening diarrhea in young children in resource-poor settings. To explore microbial influences on susceptibility, we screened 85 microbiota-associated metabolites for their effects on Cryptosporidium parvum growth in vitro. We identify eight inhibitory metabolites in three main classes: secondary bile salts/acids, a vitamin