511 research outputs found
Raças fisiológicas e linhagens de uma população contemporùnea de Magnaporthe oryzae associada à brusone do arroz irrigado no Sul do Brasil.
Objetivou-se identificar raças fisiológicas, com base em séries diferenciadoras, e linhagens, com base em marcadores microssatélites, em uma população de Magnaporthe oryzae do sul do Brasil
Constraints on from Radiative Hyperon and Kaon Decays
The quark-level process has been used extensively to place
constraints on new interactions. These same interactions can be further
constrained from the enhancement they induce in the quark-level transition, to the extent that the short distance contributions can be
separated from the long distance contributions. We parameterize what is known
about the long distance amplitudes and subtract it from the data in radiative
hyperon and kaon decays to constrain new interactions.Comment: Latex 11 page
High MBL-expressing genotypes are associated with deterioration in renal function in type 2 diabetes
Search for the K(L) --> PI0 PI0 E+ E- Decay in the KTeV Experiment
The recent discovery of a large CP violating asymmetry in K(L) --> PI+ PI- E+
E- mode has prompted us to seach for the associated K(L) --> PI0 PI0 E+ E-
decay mode in the KTeV-E799 experiment at Fermilab. In 2.7E+11 K(L) decays, one
candidate event has been observed with an expected background of 0.3 event,
resulting in an upper limit for the K(L) --> PI0 PI0 E+ E- branching ratio of
6.6E-09 at the 90% confidence level.Comment: To be published in Phys. Rev. Let
A patient-derived xenograft pre-clinical trial reveals treatment responses and a resistance mechanism to karonudib in metastatic melanoma
Karonudib (TH1579) is a novel compound that exerts anti-tumor activities and has recently entered phase I clinical testing. The aim of this study was to conduct a pre-clinical trial in patient-derived xenografts to identify the possible biomarkers of response or resistance that could guide inclusion of patients suffering from metastatic melanoma in phase II clinical trials. Patient-derived xenografts from 31 melanoma patients with metastatic disease were treated with karonudib or a vehicle for 18 days. Treatment responses were followed by measuring tumor sizes, and the models were categorized in the response groups. Tumors were harvested and processed for RNA sequencing and protein analysis. To investigate the effect of karonudib on T-cell-mediated anti-tumor activities, tumor-infiltrating T cells were injected in mice carrying autologous tumors and the mice treated with karonudib. We show that karonudib has heterogeneous anti-tumor effect on metastatic melanoma. Thus, based on the treatment responses, we could divide the 31 patient-derived xenografts in three treatment groups: progression group (32%), suppression group (42%), and regression group (26%). Furthermore, we show that karonudib has anti-tumor effect, irrespective of major melanoma driver mutations. Also, we identify high expression of ABCB1, which codes for p-gp pumps as a resistance biomarker. Finally, we show that karonudib treatment does not hamper T-cell-mediated anti-tumor responses. These findings can be used to guide future use of karonudib in clinical use with a potential approach as precision medicine
The standard model at low energies
The hadronic sector of the standard model at low energies is described by a
non--decoupling effective field theory, chiral perturbation theory. An
introduction is given to the construction of effective chiral Lagrangians, both
in the purely mesonic sector and with inclusion of baryons. The connection
between the relativistic formulation and the heavy baryon approach to chiral
perturbation theory with baryons is reviewed.Comment: Lectures given at the 6th Indian-Summer School on Intermediate Energy
Physics, Prague, Aug. 1993, Latex, 26 pages (with a4.sty), UWThPh-1993-3
Crustal structure across the Grand BanksâNewfoundland Basin Continental Margin â I. Results from a seismic refraction profile
Author Posting. © Blackwell, 2006. This is the author's version of the work. It is posted here by permission of Blackwell for personal use, not for redistribution. The definitive version was published in Geophysical Journal International 167 (2006): 127-156, doi:10.1111/j.1365-246X.2006.02988.x.A P-wave velocity model along a 565-km-long profile across the Grand
Banks/Newfoundland basin rifted margin is presented. Continental crust ~36-kmthick
beneath the Grand Banks is divided into upper (5.8-6.25 km/s), middle (6.3-
6.53 km/s) and lower crust (6.77-6.9 km/s), consistent with velocity structure of
Avalon zone Appalachian crust. Syn-rift sediment sequences 6-7-km thick occur in
two primary layers within the Jeanne dâArc and the Carson basins (~3 km/s in upper
layer; ~5 km/s in lower layer). Abrupt crustal thinning (Moho dip ~ 35Âș) beneath the
Carson basin and more gradual thinning seaward forms a 170-km-wide zone of rifted
continental crust. Within this zone, lower and middle continental crust thin
preferentially seaward until they are completely removed, while very thin (<3 km)
upper crust continues ~60 km farther seaward. Adjacent to the continental crust, high
velocity gradients (0.5-1.5 s-1) define an 80-km-wide zone of transitional basement
that can be interpreted as exhumed, serpentinized mantle or anomalously thin
oceanic crust, based on its velocity model alone. We prefer the exhumed-mantle
interpretation after considering the non-reflective character of the basement and the
low amplitude of associated magnetic anomalies, which are atypical of oceanic crust.
Beneath both the transitional basement and thin (<6 km) continental crust, a 200-kmwide
zone with reduced mantle velocities (7.6-7.9 km/s) is observed, which is
interpreted as partially (<10%) serpentinized mantle. Seaward of the transitional
basement, 2- to 6-km-thick crust with layer 2 (4.5-6.3 km/s) and layer 3 (6.3-7.2
km/s) velocities is interpreted as oceanic crust. Comparison of our crustal model
with profile IAM-9 across the Iberia Abyssal Plain on the conjugate Iberia margin
suggests asymmetrical continental breakup in which a wider zone of extended
continental crust has been left on the Newfoundland side.This research was supported by National Science Foundation (NSF)
grants OCE-9819053 and OCE-0326714, by the National Sciences and Engineering
Research Council of Canada (NSERC), and by the Danish National Research
Foundation. B. Tucholke also acknowledges support from the Henry Bryant Bigelow
Chair in Oceanography from Woods Hole Oceanographic Institution
The NE Atlantic region: a reappraisal of crustal structure, tectonostratigraphy and magmatic evolution: an introduction to the NAG-TEC project
The NE Atlantic region and its continental margins (Fig. 1) hold unique information for understanding many aspects of Earth science, from global geodynamics to palaeoceanography and global environmental change. It also holds some of the world's most important hydrocarbon reserves from the North Sea, along the Atlantic margins of Ireland, Britain and Norway, and into the Arctic in the Barents Sea. Historically, studies in the NE Atlantic were important for establishing many of the key ideas during the early part of the plate tectonic revolution. Linear magnetic anomalies along the Reykjanes Ridge were identified as early as in the 1960s (Heirtzler et al. 1966) and provided strong evidence for the seafloor spreading hypothesis (Dietz 1961), which by then had been established as a new and holistic theory (Ewing & Heezen 1956). At the same time, Iceland was already recognized as an intriguing anomalous entity (Böðvarsson & Walker 1964) and contributed to knowledge about how Earth's magnetic field reversed its polarity through time. The fact that rifting occurs in close association with old sutures and orogenic belts led Wilson to propose that the Atlantic Ocean closed and opened again, establishing the concept of the âWilson tectonic cycleâ (Wilson 1966; Dewey 1969). The North Atlantic continental margins have long been considered as archetypal, and divergent margins world-wide are commonly described as âAtlantic-type passive marginsâ. However, it is now accepted that these so-called âpassiveâ margins remain dynamic long after break-up, including post-rift vertical movements of up to kilometre scale. The type examples for such epeirogenic movements being, once again, the North Atlantic margin
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