Enhancement of shot noise due to the fluctuation of Coulomb interaction

We have developed a theoretical formalism to investigate the contribution of fluctuation of Coulomb interaction to the shot noise based on Keldysh non-equilibrium Green's function method. We have applied our theory to study the behavior of dc shot noise of atomic junctions using the method of nonequilibrium Green's function combined with the density functional theory (NEGF-DFT). In particular, for atomic carbon wire consisting 4 carbon atoms in contact with two Al(100) electrodes, first principles calculation within NEGF-DFT formalism shows a negative differential resistance (NDR) region in I-V curve at finite bias due to the effective band bottom of the Al lead. We have calculated the shot noise spectrum using the conventional gauge invariant transport theory with Coulomb interaction considered explicitly on the Hartree level along with exchange and correlation effect. Although the Fano factor is enhanced from 0.6 to 0.8 in the NDR region, the expected super-Poissonian behavior in the NDR regionis not observed. When the fluctuation of Coulomb interaction is included in the shot noise, our numerical results show that the Fano factor is greater than one in the NDR region indicating a super-Poissonian behavior

Bacterial pneumonia-induced shedding of epithelial heparan sulfate inhibits the bactericidal activity of cathelicidin in a murine model

Bacterial pneumonia is a common clinical syndrome leading to significant morbidity and mortality worldwide. In the current study, we investigate a novel, multidirectional relationship between the pulmonary epithelial glycocalyx and antimicrobial peptides in the setting of methicillin-resistant Staphylococcus aureus (MRSA) pneumonia. Using an in vivo pneumonia model, we demonstrate that highly sulfated heparan sulfate (HS) oligosaccharides are shed into the airspaces in response to MRSA pneumonia. In vitro, these HS oligosaccharides do not directly alter MRSA growth or gene transcription. However, in the presence of an antimicrobial peptide (cathelicidin), increasing concentrations of HS inhibit the bactericidal activity of cathelicidin against MRSA as well as other nosocomial pneumonia pathogens (Klebsiella pneumoniae and Pseudomonas aeruginosa) in a dose-dependent manner. Surface plasmon resonance shows avid binding between HS and cathelicidin with a dissociation constant of 0.13 μM. These findings highlight a complex relationship in which shedding of airspace HS may hamper host defenses against nosocomial infection via neutralization of antimicrobial peptides. These findings may inform future investigation into novel therapeutic targets designed to restore local innate immune function in patients suffering from primary bacterial pneumonia. NEW & NOTEWORTHY Primary Staphylococcus aureus pneumonia causes pulmonary epithelial heparan sulfate (HS) shedding into the airspace. These highly sulfated HS fragments do not alter bacterial growth or transcription, but directly bind with host antimicrobial peptides and inhibit the bactericidal activity of these cationic polypeptides. These findings highlight a complex local interaction between the pulmonary epithelial glycocalyx and antimicrobial peptides in the setting of bacterial pneumonia

Early Events Associated with Infection of Epstein-Barr Virus Infection of Primary B-Cells

Epstein Barr virus (EBV) is closely associated with the development of a vast number of human cancers. To develop a system for monitoring early cellular and viral events associated with EBV infection a self-recombining BAC containing 172-kb of the Epstein Barr virus genome BAC-EBV designated as MD1 BAC (Chen et al., 2005, J.Virology) was used to introduce an expression cassette of green fluorescent protein (GFP) by homologous recombination, and the resultant BAC clone, BAC-GFP-EBV was transfected into the HEK 293T epithelial cell line. The resulting recombinant GFP EBV was induced to produce progeny virus by chemical inducer from the stable HEK 293T BAC GFP EBV cell line and the virus was used to immortalize human primary B-cell as monitored by green fluorescence and outgrowth of the primary B cells. The infection, B-cell activation and cell proliferation due to GFP EBV was monitored by the expression of the B-cell surface antigens CD5, CD10, CD19, CD23, CD39, CD40 , CD44 and the intercellular proliferation marker Ki-67 using Flow cytometry. The results show a dramatic increase in Ki-67 which continues to increase by 6–7 days post-infection. Likewise, CD40 signals showed a gradual increase, whereas CD23 signals were increased by 6–12 hours, maximally by 3 days and then decreased. Monitoring the viral gene expression pattern showed an early burst of lytic gene expression. This up-regulation of lytic gene expression prior to latent genes during early infection strongly suggests that EBV infects primary B-cell with an initial burst of lytic gene expression and the resulting progeny virus is competent for infecting new primary B-cells. This process may be critical for establishment of latency prior to cellular transformation. The newly infected primary B-cells can be further analyzed for investigating B cell activation due to EBV infection

Mapping the Relationship Among Political Ideology, CSR Mindset, and CSR Strategy: A Contingency Perspective Applied to Chinese Managers

The literature on antecedents of corporate social responsibility (CSR) strategies of firms has been predominately content driven. Informed by the managerial sense-making process perspective, we develop a contingency theoretical framework explaining how political ideology of managers affects the choice of CSR strategy for their firms through their CSR mindset. We also explain to what extent the outcome of this process is shaped by the firm’s internal institutional arrangements and external factors impacting on the firm. We develop and test several hypotheses using data collected from 129 Chinese managers. The results show that managers with a stronger socialist ideology are likely to develop a mindset favouring CSR, which induces the adoption of a proactive CSR strategy. The CSR mindset mediates the link between socialist ideology and CSR strategy. The strength of the relationship between the CSR mindset and the choice of CSR strategy is moderated by customer response to CSR, industry competition, the role of government, and CSR-related managerial incentives

Marital therapy help-seeking attitudes of young adults in mainland China

Using qualitative interview data from young adults in Mainland China (n = 24), the current study explored help-seeking attitudes toward marital therapy. In general, significant relationship problems that participants labeled as communication difficulties, emotional distance, and thoughts of divorce were seen as legitimate reasons to seek out marital therapy. Nearly all participants reported that before seeking out professional services, they would first talk to friends and family members, and only if problems did not abate or continued to be a significant risk to relationship harmony and stability would they be open to seeking out professional services. Finally, the participants generally believed that their family and friends would support their decision to access marital therapy services. The results from this study point to the importance of developing effective, culturally relevant approaches to the treatment of marital distress in Mainland China

Attitudes toward dating violence among college students in mainland China: an exploratory study

This study investigates attitudes toward psychological and physical dating violence among college students in mainland China (n = 245). The results of this study indicate that among our sample of college students in mainland China, men and women were relatively similar in their attitudes toward male perpetrated and female perpetrated physical dating violence and female perpetrated psychological dating violence. As has been found in previous research, men and women in our sample were more accepting of female perpetrated physical and psychological dating violence than male perpetrated physical and psychological dating violence. Finally, among several variables that predicted dating violence attitudes, shame emerged as a potentially important variable to include in future studies on dating violence in Chinese populations

Marital therapy in mainland China: a qualitative study of young adults’ knowledge, attitudes, and beliefs

This qualitative study explored young adults' knowledge, attitudes, and beliefs about marital therapy in Mainland China. Participants (N = 24) were undergraduate and graduate students attending university in Beijing and Guangzhou. Four themes emerged from the data analysis: (1) beliefs regarding marital therapy, (2) role of the therapist, (3) barriers to seeking marital therapy, and (4) greater accessibility to marital therapy. In general, our participants knew little about marital therapy and were concerned that using such services could bring shame to them or to their family and that the cost of such services would be beyond most citizens' means. In addition, participants believed that marital therapists would serve as experts doling out relationship advice, whereas clients would generally take a passive role. Increased government support, alternative forms of treatment that included phone and web-based services as a way to protect anonymity and therefore confidentiality, and government credentialing were seen as steps that could increase the use and accessibility of marital therapy in Mainland China

Morphology of Σ3{<110>/70.53°} grain boundaries in a C15 intermetallic compound

A C15 Laves phase, HfV2+Nb, shows promising mechanical properties and here we describe the structure of its grain boundaries. The C15 Laves phase has a fcc lattice with a=7.4Å. An alloy of composition Hf14V64Nb22 (including a C15 matrix and a second phase of V-rich bcc solution) was made by arc-melting. The alloy was homogenized at 1200°C for 120h. Preliminary study concentrated on Σ3{&lt;110&gt;/70.53°} grain boundaries in the C15 phase using Philips 400T and CM 30 microscopes.The most-commonly observed morphology of Σ3{&lt;110&gt;/70.53°} grain boundaries in the C15 phase is a faceted boundary. A bright field image (BFI) of the faceted boundary and the corresponding diffraction patterns with the grain boundary edge-on are shown in Fig. 1(a). From the diffraction patterns using a &lt;110&gt; zone axis for both grains, it is obvious that this is a Σ3{&lt;110&gt;/70.53°} grain boundary. Crystallographic analysis shows that the Σ3{&lt;110&gt;/70.53°} grain boundaries selectively facet with the following relationships between the two grains: {111}1//{111}2, {112}1//{112}2, {111}1//{115}2, and {001}1//{221}2.</jats:p