The origin of planetary impactors in the inner solar system

New insights into the history of the inner solar system are derived from the impact cratering record of the Moon, Mars, Venus and Mercury, and from the size distributions of asteroid populations. Old craters from a unique period of heavy bombardment that ended $\sim$3.8 billion years ago were made by asteroids that were dynamically ejected from the main asteroid belt, possibly due to the orbital migration of the giant planets. The impactors of the past $\sim$3.8 billion years have a size distribution quite different from the main belt asteroids, but very similar to the population of near-Earth asteroids.Comment: 12 pages (including 4 figures

Response of a Fermi gas to time-dependent perturbations: Riemann-Hilbert approach at non-zero temperatures

We provide an exact finite temperature extension to the recently developed Riemann-Hilbert approach for the calculation of response functions in nonadiabatically perturbed (multi-channel) Fermi gases. We give a precise definition of the finite temperature Riemann-Hilbert problem and show that it is equivalent to a zero temperature problem. Using this equivalence, we discuss the solution of the nonequilibrium Fermi-edge singularity problem at finite temperatures.Comment: 10 pages, 2 figures; 2 appendices added, a few modifications in the text, typos corrected; published in Phys. Rev.

Fermi edge singularity in a non-equilibrium system

We report exact results for the Fermi Edge Singularity in the absorption spectrum of an out-of-equilibrium tunnel junction. We consider two metals with chemical potential difference V separated by a tunneling barrier containing a defect, which exists in one of two states. When it is in its excited state, tunneling through the otherwise impermeable barrier is possible. We find that the lineshape not only depends on the total scattering phase shift as in the equilibrium case but also on the difference in the phase of the reflection amplitudes on the two sides of the barrier. The out-of-equilibrium spectrum extends below the original threshold as energy can be provided by the power source driving current across the barrier. Our results have a surprisingly simple interpretation in terms of known results for the equilibrium case but with (in general complex-valued) combinations of elements of the scattering matrix replacing the equilibrium phase shifts.Comment: 4 page

Energy-dependent effective interactions for dilute many-body systems

We address the issue of determining an effective two-body interaction for mean-field calculations of energies of many-body systems. We show that the effective interaction is proportional to the phase shift, and demonstrate this result in the quasiclassical approximation when there is a trapping potential in addition to the short-range interaction between a pair of particles. We calculate numerically energy levels for the case of an interaction with a short-range square-well and a harmonic trapping potential and show that the numerical results agree well with the analytical expression. We derive a generalized Gross--Pitaevskii equation which includes effective range corrections and discuss the form of the electron--atom effective interaction to be used in calculations of Rydberg atoms and molecules.Comment: 6 pages, 2 figure

Fermi-edge problem in the presence of AC electric field

We study in this paper a non-equilibrium Fermi-edge problem where the system under investigation is a single electron reservoir putting under an AC electric field. We show that the electron Green's function and other correlation functions in the problem can be solved and expressed exactly in terms of a well-defined integral. The qualitative behaviors of the solution is studied and compared with the situation where the impurity is coupled to more than one reservoirs at different chemical potentials.Comment: Published versio

Emerging roles of ATG7 in human health and disease

The cardinal stages of macroautophagy are driven by core autophagy-related (ATG) proteins, whose ablation largely abolishes intracellular turnover. Disrupting ATG genes is paradigmatic of studying autophagy deficiency, yet emerging data suggest that ATG proteins have extensive biological importance beyond autophagic elimination. An important example is ATG7, an essential autophagy effector enzyme that in concert with other ATG proteins, also regulates immunity, cell death and protein secretion, and independently regulates the cell cycle and apoptosis. Recently, a direct association between ATG7 dysfunction and disease was established in patients with biallelic ATG7 variants and childhood-onset neuropathology. Moreover, a prodigious body of evidence supports a role for ATG7 in protecting against complex disease states in model organisms, although how dysfunctional ATG7 contributes to manifestation of these diseases, including cancer, neurodegeneration and infection, in humans remains unclear. Here, we systematically review the biological functions of ATG7, discussing the impact of its impairment on signalling pathways and human pathology. Future studies illuminating the molecular relationship between ATG7 dysfunction and disease will expedite therapies for disorders involving ATG7 deficiency and/or impaired autophagy.Peer reviewe

FANTOM5 CAGE profiles of human and mouse samples

In the FANTOM5 project, transcription initiation events across the human and mouse genomes were mapped at a single base-pair resolution and their frequencies were monitored by CAGE (Cap Analysis of Gene Expression) coupled with single-molecule sequencing. Approximately three thousands of samples, consisting of a variety of primary cells, tissues, cell lines, and time series samples during cell activation and development, were subjected to a uniform pipeline of CAGE data production. The analysis pipeline started by measuring RNA extracts to assess their quality, and continued to CAGE library production by using a robotic or a manual workflow, single molecule sequencing, and computational processing to generate frequencies of transcription initiation. Resulting data represents the consequence of transcriptional regulation in each analyzed state of mammalian cells. Non-overlapping peaks over the CAGE profiles, approximately 200,000 and 150,000 peaks for the human and mouse genomes, were identified and annotated to provide precise location of known promoters as well as novel ones, and to quantify their activities

DGAT1 activity synchronises with mitophagy to protect cells from metabolic rewiring by iron depletion

Mitophagy removes defective mitochondria via lysosomal elimination. Increased mitophagy coincides with metabolic reprogramming, yet it remains unknown whether mitophagy is a cause or consequence of such state changes. The signalling pathways that integrate with mitophagy to sustain cell and tissue integrity also remain poorly defined. We performed temporal metabolomics on mammalian cells treated with deferiprone, a therapeutic iron chelator that stimulates PINK1/PARKIN-independent mitophagy. Iron depletion profoundly rewired the metabolome, hallmarked by remodelling of lipid metabolism within minutes of treatment. DGAT1-dependent lipid droplet biosynthesis occurred several hours before mitochondrial clearance, with lipid droplets bordering mitochondria upon iron chelation. We demonstrate that DGAT1 inhibition restricts mitophagy in vitro, with impaired lysosomal homeostasis and cell viability. Importantly, genetic depletion of DGAT1 in vivo significantly impaired neuronal mitophagy and locomotor function in Drosophila. Our data define iron depletion as a potent signal that rapidly reshapes metabolism and establishes an unexpected synergy between lipid homeostasis and mitophagy that safeguards cell and tissue integrity.Peer reviewe