34 research outputs found
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LRRK2 at the interface of autophagosomes, endosomes and lysosomes
Over the past 20 years, substantial progress has been made in identifying the underlying genetics of Parkinsonâs disease (PD). Of the known genes, LRRK2 is a major genetic contributor to PD. However, the exact function of LRRK2 remains to be elucidated. In this review, we discuss how familial forms of PD have led us to hypothesize that alterations in endomembrane trafficking play a role in the pathobiology of PD. We will discuss the major observations that have been made to elucidate the role of LRRK2 in particular, including LRRK2 animal models and high-throughput proteomics approaches. Taken together, these studies strongly support a role of LRRK2 in vesicular dynamics. We also propose that targeting these pathways may not only be beneficial for developing therapeutics for LRRK2-driven PD, but also for other familial and sporadic cases
Changes in Shear Strain and Subsurface Flow Prior to Rainfall-Induced Landslide in Flume Experiments
Flood perception and mitigation: The role of severity, agency, and experience in the purchase of flood protection, and the communication of flood information
Protection of human life and property from flooding is a strategic priority in
the UK. We examine how to encourage home owners to protect themselves and their
residences. A model of factors that influence the decision to buy flood
protection devices is tested using survey data from 2,109 home owners. The
results showed that the majority of respondents have not purchased domestic
flood protection (N=1,732; 82.1%). Purchase of flood protection devices was
influenced by age; perceived seriousness; and beliefs about, and trust in, the
role of regulators in managing flooding. In younger respondents, the perceived
seriousness of the dangers of flooding acted as precursors and barriers to
action depending on individual sense of responsibility and agency. The second
part of the study examined responsiveness to information. Information about
flooding alone was insufficient to promote behavioural change, particularly
among people who have not experienced a flood or who believe that they are not
in a flood zone. Implications for understanding flood protection, managing
agency issues, and flood communication campaigns are discussed