Acoustic echo and noise canceller for personal hands-free video IP phone

This paper presents implementation and evaluation of a proposed acoustic echo and noise canceller (AENC) for videotelephony-enabled personal hands-free Internet protocol (IP) phones. This canceller has the following features: noise-robust performance, low processing delay, and low computational complexity. The AENC employs an adaptive digital filter (ADF) and noise reduction (NR) methods that can effectively eliminate undesired acoustic echo and background noise included in a microphone signal even in a noisy environment. The ADF method uses the step-size control approach according to the level of disturbance such as background noise; it can minimize the effect of disturbance in a noisy environment. The NR method estimates the noise level under an assumption that the noise amplitude spectrum is constant in a short period, which cannot be applied to the amplitude spectrum of speech. In addition, this paper presents the method for decreasing the computational complexity of the ADF process without increasing the processing delay to make the processing suitable for real-time implementation. The experimental results demonstrate that the proposed AENC suppresses echo and noise sufficiently in a noisy environment; thus, resulting in natural-sounding speech

小脳型多系統萎縮症と皮質性小脳萎縮症のtractographyを用いた小脳遠心路・求心路の損傷評価

Se aborda la importancia del periodismo en la difusión y empoderamiento de la cultura montuvia en la provincia de Manabí. Se pone énfasis en la transmisión de la interculturalidad a través del uso de los medios de comunicación masiva y espacios definidos para el reconocimiento de las principales manifestaciones culturales de la provincia. Asimismo, desde la academia, actores sociales y medios de comunicación se pretende fomentar el uso del amorfino como práctica cultural y ejemplo de ruralidad. En ese sentido el rescate del Amorfino cobra valor porque es parte del acervo cultural del campesinado Manabita.It  deals  with  the  importance  of  the  journalism  in  the broadcasting and empowerment of the culture montuvia in the province of Manabí. Emphasis is placed on the diffusion of multiculturalism through the use of the means of mass media and spaces defined for the recognition of the main cultural events of the province. Also, from the Academy, the actors social and media of communication is intended to promote the recognition of the amorfino as practice cultural and example of rurality. In that sense the Amorfino rescue takes value because it is part of the cultural heritage of the Manabita peasantry

A ternary complex model of Sirtuin4-NAD+-Glutamate dehydrogenase

Sirtuin4 (Sirt4) is one of the mammalian homologues of Silent information regulator 2 (Sir2), which promotes the longevity of yeast, C. elegans, fruit flies and mice. Sirt4 is localized in the mitochondria, where it contributes to preventing the development of cancers and ischemic heart disease through regulating energy metabolism. The ADP-ribosylation of glutamate dehydrogenase (GDH), which is catalyzed by Sirt4, downregulates the TCA cycle. However, this reaction mechanism is obscure, because the structure of Sirt4 is unknown. We here constructed structural models of Sirt4 by homology modeling and threading, and docked nicotinamide adenine dinucleotide+ (NAD+) to Sirt4. In addition, a partial GDH structure was docked to the Sirt4-NAD+ complex model. In the ternary complex model of Sirt4-NAD+-GDH, the acetylated lysine 171 of GDH is located close to NAD+. This suggests a possible mechanism underlying the ADP-ribosylation at cysteine 172, which may occur through a transient intermediate with ADP-ribosylation at the acetylated lysine 171. These results may be useful in designing drugs for the treatment of cancers and ischemic heart disease

Structure models of G72, the product of a susceptibility gene to schizophrenia

The G72 gene is one of the most susceptible genes to schizophrenia and is contained exclusively in the genomes of primates. The product of the G72 gene modulates the activity of D-amino acid oxidase (DAO) and is a small protein prone to aggregate, which hampers its structural studies. In addition, lack of a known structure of a homologue makes it difficult to use the homology modeling method for the prediction of the structure. Thus, we first developed a hybrid ab initio approach for small proteins prior to the prediction of the structure of G72. The approach uses three known ab initio algorithms. To evaluate the hybrid approach, we tested our prediction of the structure of the amino acid sequences whose structures were already solved and compared the predicted structures with the experimentally solved structures. Based on these comparisons, the average accuracy of our approach was calculated to be ∼5 Å. We then applied the approach to the sequence of G72 and successfully predicted the structures of the N- and C-terminal domains (ND and CD, respectively) of G72. The predicted structures of ND and CD were similar to membrane-bound proteins and adaptor proteins, respectively

キギョウ ノ ベンゴシ ヤクワリカン ハ カワリツツ アル ノ カ ベンゴシ ギョウム ニ カンスル ミッツ ノ アンケート チョウサ カラ

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