Neuroprotective DAMPs member prothymosin alpha has additional beneficial actions against cerebral ischemia-induced vascular damages

AbstractProthymosin alpha (ProTα) suppresses stress-induced necrosis of cultured cortical neurons. As neuroprotection alone could not explain the long-lasting protective actions against cerebral ischemia by ProTα, we further examined whether ProTα, in addition to neuroprotective effects, has other anti-ischemic activities. When recombinant mouse ProTα (rmProTα) at 0.3 mg/kg was intravenously (i.v.) given 2 h after the start of tMCAO, all mice survived for more than 14 days. In evaluation of CD31- and tomato lectin-labeling as well as IgG and Evans blue leakage, rmProTα treatment (0.1 mg/kg) largely blocked ischemia-induced vascular damages. Therefore, rmProTα has novel beneficial effects against ischemia-induced brain damage through vascular mechanisms

Fan-shaped aurora as seen from Japan during a great magnetic storm on February 11, 1958

During a great magnetic storm on Feb 11, 1958, a fan-shaped aurora was photographed at Memambetsu, Hokkaido, Japan – the first and oldest photograph record of auroras observed in Japan, accompanied by many hand-made drawings, thus, portraying a rare opportunity of coexistence between photograph images and hand-made drawings. In fact, the same portrayal reminds us of the great red aurora with fan-shaped white pillars observed during the 1872 and 1770 great magnetic storms. The hand-made sketches, photographs, and the spectral data revealed that the white pillars and red glow of the fan-shaped aurora were dominated by auroral green and red lines, respectively. From the analysis of newly digitized microfilm data and hand-made drawings, we found that the fan-shaped aurora appeared during the peak activity of magnetic storm and moved westward at 0.4 km/s at 400-km altitude at 38°–40° magnetic latitudes, which is consistent with the enhanced convection pattern in the middle latitude at storm time. Such a fan-shaped aurora can fundamentally characterize the middle-latitude evening-to-midnight auroras during great magnetic storms, which show the most destabilized transient appearance of the inner magnetosphere

Virus-Infection or 5′ppp-RNA Activates Antiviral Signal through Redistribution of IPS-1 Mediated by MFN1

In virus-infected cells, RIG-I-like receptor (RLR) recognizes cytoplasmic viral RNA and triggers innate immune responses including production of type I and III interferon (IFN) and the subsequent expression of IFN-inducible genes. Interferon-β promoter stimulator 1 (IPS-1, also known as MAVS, VISA and Cardif) is a downstream molecule of RLR and is expressed on the outer membrane of mitochondria. While it is known that the location of IPS-1 is essential to its function, its underlying mechanism is unknown. Our aim in this study was to delineate the function of mitochondria so as to identify more precisely its role in innate immunity. In doing so we discovered that viral infection as well as transfection with 5′ppp-RNA resulted in the redistribution of IPS-1 to form speckle-like aggregates in cells. We further found that Mitofusin 1 (MFN1), a key regulator of mitochondrial fusion and a protein associated with IPS-1 on the outer membrane of mitochondria, positively regulates RLR-mediated innate antiviral responses. Conversely, specific knockdown of MFN1 abrogates both the virus-induced redistribution of IPS-1 and IFN production. Our study suggests that mitochondria participate in the segregation of IPS-1 through their fusion processes

Seismicity controlled by resistivity structure : the 2016 Kumamoto earthquakes, Kyushu Island, Japan

The M JMA 7.3 Kumamoto earthquake that occurred at 1:25 JST on April 16, 2016, not only triggered aftershocks in the vicinity of the epicenter, but also triggered earthquakes that were 50–100 km away from the epicenter of the main shock. The active seismicity can be divided into three regions: (1) the vicinity of the main faults, (2) the northern region of Aso volcano (50 km northeast of the mainshock epicenter), and (3) the regions around three volcanoes, Yufu, Tsurumi, and Garan (100 km northeast of the mainshock epicenter). Notably, the zones between these regions are distinctively seismically inactive. The electric resistivity structure estimated from one-dimensional analysis of the 247 broadband (0.005–3000 s) magnetotelluric and telluric observation sites clearly shows that the earthquakes occurred in resistive regions adjacent to conductive zones or resistive-conductive transition zones. In contrast, seismicity is quite low in electrically conductive zones, which are interpreted as regions of connected fluids. We suggest that the series of the earthquakes was induced by a local accumulated stress and/or fluid supply from conductive zones. Because the relationship between the earthquakes and the resistivity structure is consistent with previous studies, seismic hazard assessment generally can be improved by taking into account the resistivity structure. Following on from the 2016 Kumamoto earthquake series, we suggest that there are two zones that have a relatively high potential of earthquake generation along the western extension of the MTL

Lubiprostone Decreases the Small Bowel Transit Time by Capsule Endoscopy: An Exploratory, Randomised, Double-Blind, Placebo-Controlled 3-Way Crossover Study

The aim of this study was to investigate the usefulness of lubiprostone for bowel preparation and as a propulsive agent in small bowel endoscopy. Six healthy male volunteers participated in this randomized, 3-way crossover study. The subjects received a 24 μg tablet of lubiprostone 60 minutes prior to the capsule ingestion for capsule endoscopy (CE) and a placebo tablet 30 minutes before the capsule ingestion (L-P regimen), a placebo tablet 60 minutes prior to CE and a 24 μg tablet of lubiprostone 30 minutes prior to CE (P-L regimen), or a placebo tablet 60 minutes prior to r CE and a placebo tablet again 30 minutes prior to CE (P-P regimen). The quality of the capsule endoscopic images and the amount of water in the small bowel were assessed on 5-point scale. The median SBTT was 178.5 (117–407) minutes in the P-P regimen, 122.5 (27–282) minutes in the L-P regimen, and 110.5 (11–331) minutes in the P-L regimen (P=0.042). This study showed that the use of lubiprostone significantly decreased the SBTT. We also confirmed that lubiprostone was effective for inducing water secretion into the small bowel during CE

A県産業看護職の就労実態と業務及び研修に関する調査研究

A県産業看護職の就労実態、業務および研修状況の把握を目的に、県内産業看護部会員に調査を依頼し、43名の回答を得た。産業看護職の8割は保健師で、企業等に約6割、健診機関等に約4割が勤務していた。企業等では健康管理を中心とした総合的な保健活動が実施され、健診機関等では、健康相談・保健指導・健康教育を主としており、職務内容に違いがあった。職務の違いがあるものの、職場の健康課題や受けたい研修は両者ともメンタルヘルスであった。今後、A産業看護部会では事業所の課題や研修の希望を部会活動に反映させていくことが必要である

20kmメッシュ大規模アンサンブル実験を用いた北東日本における極端低温日の将来変化予測

This study investigates future changes to extremely cool days (ECDs) during the summer (June-August) season in northeastern Japan by applying self-organizing map (SOM) technique to large ensemble simulations from the "database for Policy Decision making for Future climate change" (d4PDF). Two separate SOMs, one trained on mean sea level pressure using a combination of JRA-55 reanalysis and d4PDF to evaluate model performance, and a "master" SOM, which trained the SOMs using historical, +2K, and +4K simulations, were created to investigate possible climate change impacts to future ECDs. For model evaluation, summer climatology and ECDs were confirmed to occur with similar frequencies between circulation patterns in the JRA-55 and d4PDF. Surface temperature anomalies and horizontal wind composite from several high-frequency ECD nodes exhibit similar spatial patterns for all days and ECD occurring in the node, with ECD composites depicting particularly strong northeasterly winds, commonly referred to as Yamase, blowing from high latitudes toward northeast Japan. Future changes using "master" SOMs suggest a gradual shift (from +2K to +4K) in preferred circulation patterns that result in ECDs, with the greatest increase in frequency associated to those with a strong low-pressure system off eastern Japan and a moderate intensity Okhotsk Sea high, and decreased ECDs to those with either a strong Okhotsk Sea high or westward extension of the North Pacific high. Lastly, changes to the intensity of future ECDs are investigated by examining low-level thermal advection. Results suggest that circulation patterns associated with increased ECD frequency coincide with those with very strong cold air advection for all climates, though the magnitude differs based on circulation patterns. Future changes show a weakening cold air advection and decreasing ECDs, due in large part to the weakening meridional temperature gradient east of Japan

Fan-shaped aurora as seen from Japan during a great magnetic storm on February 11, 1958

During a great magnetic storm on Feb 11, 1958, a fan-shaped aurora was photographed at Memambetsu, Hokkaido, Japan – the first and oldest photograph record of auroras observed in Japan, accompanied by many hand-made drawings, thus, portraying a rare opportunity of coexistence between photograph images and hand-made drawings. In fact, the same portrayal reminds us of the great red aurora with fan-shaped white pillars observed during the 1872 and 1770 great magnetic storms. The hand-made sketches, photographs, and the spectral data revealed that the white pillars and red glow of the fan-shaped aurora were dominated by auroral green and red lines, respectively. From the analysis of newly digitized microfilm data and hand-made drawings, we found that the fan-shaped aurora appeared during the peak activity of magnetic storm and moved westward at 0.4 km/s at 400-km altitude at 38°–40° magnetic latitudes, which is consistent with the enhanced convection pattern in the middle latitude at storm time. Such a fan-shaped aurora can fundamentally characterize the middle-latitude evening-to-midnight auroras during great magnetic storms, which show the most destabilized transient appearance of the inner magnetosphere