184 research outputs found
Of Stalks and Diamonds. Simulation Studies of Membrane Fusion and the Role of Fusion Peptides
Subjektive Vaterschaftskonzepte und ihre Determinanten in drei Familienentwicklungsphasen : eine latente Profilanalyse multipler Gruppen und multivariate Untersuchung verschiedener Determinanten
Magdeburg, Univ., Fak. für Humanwiss., Diss., 2013von Franziska Fuhrman
Study of pinning at 3D-2D phase transition in vortex matter of strongly anisotropic high-temperature superconductors of BiPbSrCaCuO system
Sharp increase of pinning force was observed at the 3D-2D phase transition in
strongly anisotropic high temperature superconductors of the BiPbSrCaCuO
system.Comment: 5 page
Investigation of stimulated dynamics in strongly anisotropic high-temperature superconductors system Bi-Pb-Sr-Ca-Cu-O
It is used the mechanical method of Abrikosov vortex stimulated dynamics
investigation in superconductors. With its help it was studied relaxation
phenomena in vortex matter of high-temperature superconductors. It established
that pulsed magnetic fields change the course of relaxation processes taking
place in vortex matter. The study of the influence of magnetic pulses differing
by their durations and amplitudes on vortex system of strongly anisotropic
high-temperature superconductors system Bi1.7Pb0.3Sr2Ca2Cu3O10-d showed the
presence of threshold phenomena. The small duration pulses do not change the
course of relaxation processes taking place in vortex matter. When the duration
of pulses exceeds some critical value (threshold), then their influence change
the course of relaxation process which is revealed by stepwise change of
relaxing mechanical moment.. These investigation showed that the time for
formatting of Abrikosov vortex lattice in Bi1.7Pb0.3Sr2Ca2Cu3O10-d is of the
order of 150 us which on the order of value exceeds the time necessary for
formation of a single vortex observed in isotropic high-temperature
superconductor HoBa2Cu3O7-d and on two orders exceeds the creation time of a
single vortex observed in classical type II superconductors.Comment: 6 pages, 0 figure
Creating application-specific metadata profiles while improving interoperability and consistency of research data for the engineering sciences
Due to the heterogeneity of data, methods, experiments,
and research questions and the necessity to describe
flexible and short-lived setups, no widely used subject-specific
metadata schemata or terminologies have been established for
the field of engineering (as well as for other disciplines facing
similar challenges). Nevertheless, it is highly desirable to realize
consistent and machine-actionable documentation of research
data via structured metadata.
In this article, we introduce a way to create subject specific
RDF-compliant metadata profiles (in the sense of SHACL
shapes) that allow precise and flexible documentation of research
processes and data. We introduce a hierarchical inheritance
concept for the profiles that we combine with a strategy that
uses composition of relatively simple modular profiles to model
complex setups. As a result, the individual profiles are highly
reusable and can be applied in different contexts, which, in
turn, increases the interoperability of the resulting data. We also
demonstrate that it is possible to achieve a level of detail that is
sufficiently specific for most applications, even when only general
terms are available within existing terminologies, avoiding the
need to create highly specific terminologies that would only have
limited reusability
Value‐Based Insurance Design: More Health at Any Price
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90286/1/hesr1358.pd
Investigation of stimulated dynamics of vortex-matter in high-temperature superconductors
A simple mechanical method for the investigation of Abrikosov vortex lattice
stimulated dynamics in superconductors has been used. By this method we studied
the action of pulsed magnetic fields on the vortex lattice and established the
resulting change of the course of relaxation processes in the vortex matter in
high-temperature superconductors. This method can be used for investigation of
phase transitions in vortex matter both high-temperature and exotic
superconductors.Comment: 5 pages, 6 figure
Interoperabilität von Metadaten innerhalb der NFDI: Konsortienübergreifender Metadaten-Workshop am 2./3. Juli 2020
Auf einem virtuellen Metadatenworkshop diskutierten Vertreterinnen und Vertreter von 17 verschiedenen NFDI-Konsortien Konzepte zur Interoperabilität von Metadaten in Bezug auf inhaltliche Überschneidungen, Herangehensweisen zur Metadatenmodellierung, technische Aspekte und Infrastruktur bis hin zu organisatorischen Aspekten und Zusammenarbeit. Die vertretenen Konsortien möchten auch in Zukunft eng im Bereich Metadaten zusammenarbeiten und Standards schaffen, die es Forschenden in der Zukunft möglich machen, ihre Forschungsergebnisse gleichzeitig spezifisch und interoperabel zu beschreiben. Die Dynamik der Formierung der Nationalen Forschungsdateninfrastruktur (NFDI) soll für Einigung über allgemein bedeutsame Fragen der Metadatierung genutzt werden. Zudem sollen mit Unterstützung des NFDI-Direktorats Strukturen zur gemeinsamen Standardisierungsarbeit geschaffen und international vernetzt werden
Fusing simulation and experiment: The effect of mutations on the structure and activity of the influenza fusion peptide
During the infection process, the influenza fusion peptide (FP) inserts into the host membrane, playing a crucial role in the fusion process between the viral and host membranes. In this work we used a combination of simulation and experimental techniques to analyse the molecular details of this process, which are largely unknown. Although the FP structure has been obtained by NMR in detergent micelles, there is no atomic structure information in membranes. To answer this question, we performed bias-exchange metadynamics (BE-META) simulations, which showed that the lowest energy states of the membrane-inserted FP correspond to helical-hairpin conformations similar to that observed in micelles. BE-META simulations of the G1V, W14A, G12A/G13A and G4A/G8A/G16A/G20A mutants revealed that all the mutations affect the peptide's free energy landscape. A FRET-based analysis showed that all the mutants had a reduced fusogenic activity relative to the WT, in particular the mutants G12A/G13A and G4A/G8A/G16A/G20A. According to our results, one of the major causes of the lower activity of these mutants is their lower membrane affinity, which results in a lower concentration of peptide in the bilayer. These findings contribute to a better understanding of the influenza fusion process and open new routes for future studies
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