Alternative treatments in the control of psoroptic mange in a flock of organic production sheep.

Abstract The aim of the experiment was to verify the efficacy of the treatment of psoroptic mange in a flock of Churra sheep farmed under organic production conditions, using alternative methods. One group, C Control (N=9), was given no treatment, a second group, TAH Antihomotoxic (N=10), was intramuscularly administered an antihomotoxic preparation every two days, thus receiving a total of seven injections over a two-week period. The third group, TCI Citronella (N=10), was topically administered a 1% solution of 50%essential Citronella Java oil and 50% Potassium Soap twice daily, in each milking, during the two-week period. A fourth group, TCIT Citronella+Thymol (N=10), was topically administered Citronella with 1% mother tincture of Thymol to boost the acaricide activity. The results obtained were analysed by ANOVA for scores and improvement of lesions. At the end of the experiment, TCI and TCIT showed significantly fewer lesions (P<0.05) than the control group and TAH, no differences being detected between the latter two groups. Improvement was significantly higher (P<0.05) in TCI (45%) and TCTT (48%) in comparison with the control group,which only showed 3% improvement. TAH improved by 30% (P<0.05) in comparison with the control group. There were no significant differences between TCI and TCIT. In conclusion, treatment with essential Citronella Java oil and potassium soap can be used as an alternative to conventional methods to control psoroptic mange

Study of urgent visits to commercial rabbit farms in Spain and Portugal during 1997-2007

[EN] This is a report on work carried out on 4307 visits to 868 commercial farms with domestic rabbits in Spain and Portugal from January 1997 to December 2007. Of the total visits, 2237 (52%) were emergencies on 660 farms. The median size of the farms ranged between 450 does in 1997 and 750 in 2007. This retrospective study measures the clinical disease occurrence using the Monthly Risk of urgent visits (MR), i.e. the percentage of visits made as a result of each clinical disease in comparison with the total number of urgent visits made each month. The main reasons for the emergencies were mucoid enteropathy (similar to Epizootic Rabbit Enteropathy), with a MR: 25.0%, enteritis-diarrhoea (24.1%), myxomatosis, (11.1%), reproductive troubles (8.6%), respiratory diseases (7.2%) and staphylococcosis (4.2%). Fifty-four percent of the urgent visits were due to diseases of the digestive system. Mucoid enteropathy was still one of the main diseases faced by the commercial rabbit industry during the study period. No significant yearly or monthly variations were observed in the analysis of the MR. A seasonal effect was only found in respiratory diseases during the summer (MR: 11.06±0.01) and myxomatosis in autumn (MR: 14.60±0.02), in comparison with spring (MR: 7.44±0.02). It is therefore concluded that farms should be permanently protected as they might be affected by any of these diseases at any time during the year.Rosell, J.; Fuente, LDL.; Badiola, J.; Fernández De Luco, D.; Casal, J.; Saco, M. (2009). Study of urgent visits to commercial rabbit farms in Spain and Portugal during 1997-2007. World Rabbit Science. 17(3):127-136. doi:10.4995/wrs.2009.65212713617

Variaciones temporales del contenido en ácidos grasos de leche de oveja

El presente trabajo ha consistido en la estimación de la repetibilidad tem- poral diaria, semanal y mensual, del contenido de los ácidos grasos de la leche de oveja en el curso de una lactación. Se ha realizado la cuantificación para 36 ácidos grasos y 6 agrupaciones en 596 muestras de leche procedente de 32 ovejas de las razas Churra y Assaf. Las bajas repetibilidades, en aquellos ácidos con muy baja concentración, son debido a un efecto de falta de precisión en su cuantificación, originado por el bajo contenido de dicho ácido graso. La concentración de ácidos grasos en la leche ovina, presenta una variación a lo largo de la lactación que es proporcional a las distancia entre controles. Para las variables cuantitativamente importantes, las repetibilidades medias diarias, semanales y mensuales fueron 0,55, 0,46 y 0,32 respectivamente

Análisis del genoma ovino para la identificación de QTL con influencia sobre caracteres de morfología mamaria: resultados preliminares

Ponencia publicada en ITEA, vol.104El objetivo del presente estudio es la localización de regiones genómicas con influencia sobre caracteres de morfología mamaria en ganado ovino, utilizando la metodología de genome scan, o barrido genómico. Con este fin, se ha analizado una población comercial de ganado ovino de raza Churra, organizada en un diseño hija compuesto por 8 familias de medio-hermanas. Un total de 182 marcadores genéticos, distribuidos uniformemente a lo largo del genoma ovino autosómico, fueron genotipados en la población objeto de estudio. Como medidas cuantitativas se utilizaron las desviaciones calculadas para los caracteres de morfología mamaria considerados en el programa de mejora genética de la raza ovina Churra: inserción de la ubre, posición de los pezones, tamaño de los pezones, profundidad y forma global de la ubre. Para la identificación de los QTL se realizó un análisis de regresión de los fenotipos con marcadores flanqueantes. El análisis del genoma para el conjunto de la población permitió la identificación de 11 regiones asociadas con estos caracteres, al nivel chromosome-wise, en los siguientes cromosomas: 4, 6, 7, 8, 10, 14, 15, 20, 22, 23 y 26. Para las asociaciones significativas se debe realizar una verificación previamente al abordaje del mapeo fino.Analysing the ovine genome to detect QTL for mammary morphology: preliminary results The objective of this work was the identification of chromosomal regions influencing udder morphology traits in dairy sheep by using the genome scan approach. For this purpose, we have analyzed a commercial population of Spanish Churra sheep organized according a daughter design, which included 8 half-sib families. A total of 182 genetic markers, evenly distributed along the ovine autosome, were genotyped in the studied population. As quantitative measurements for the analysis, we used the yield deviations calculated for each of the udder traits considered in the breeding program of Churra sheep: udder attachment, teat position and teat size, udder depth and udder shape. A multimarker regression analysis was used to detect QTL. The whole genome analysis allowed the identification of 11 chromosome-wide significant regions associated with the traits analyzed in the following chromosomes: 4, 6, 7, 8, 10, 14, 15, 20, 22, 23 y 26. Confirmation of the detected effects is required before attempting future fine mapping studies on these regions

EPIdemiology of Surgery-Associated Acute Kidney Injury (EPIS-AKI) : Study protocol for a multicentre, observational trial

More than 300 million surgical procedures are performed each year. Acute kidney injury (AKI) is a common complication after major surgery and is associated with adverse short-term and long-term outcomes. However, there is a large variation in the incidence of reported AKI rates. The establishment of an accurate epidemiology of surgery-associated AKI is important for healthcare policy, quality initiatives, clinical trials, as well as for improving guidelines. The objective of the Epidemiology of Surgery-associated Acute Kidney Injury (EPIS-AKI) trial is to prospectively evaluate the epidemiology of AKI after major surgery using the latest Kidney Disease: Improving Global Outcomes (KDIGO) consensus definition of AKI. EPIS-AKI is an international prospective, observational, multicentre cohort study including 10 000 patients undergoing major surgery who are subsequently admitted to the ICU or a similar high dependency unit. The primary endpoint is the incidence of AKI within 72 hours after surgery according to the KDIGO criteria. Secondary endpoints include use of renal replacement therapy (RRT), mortality during ICU and hospital stay, length of ICU and hospital stay and major adverse kidney events (combined endpoint consisting of persistent renal dysfunction, RRT and mortality) at day 90. Further, we will evaluate preoperative and intraoperative risk factors affecting the incidence of postoperative AKI. In an add-on analysis, we will assess urinary biomarkers for early detection of AKI. EPIS-AKI has been approved by the leading Ethics Committee of the Medical Council North Rhine-Westphalia, of the Westphalian Wilhelms-University Münster and the corresponding Ethics Committee at each participating site. Results will be disseminated widely and published in peer-reviewed journals, presented at conferences and used to design further AKI-related trials. Trial registration number NCT04165369

Construction status and prospects of the Hyper-Kamiokande project

The Hyper-Kamiokande project is a 258-kton Water Cherenkov together with a 1.3-MW high-intensity neutrino beam from the Japan Proton Accelerator Research Complex (J-PARC). The inner detector with 186-kton fiducial volume is viewed by 20-inch photomultiplier tubes (PMTs) and multi-PMT modules, and thereby provides state-of-the-art of Cherenkov ring reconstruction with thresholds in the range of few MeVs. The project is expected to lead to precision neutrino oscillation studies, especially neutrino CP violation, nucleon decay searches, and low energy neutrino astronomy. In 2020, the project was officially approved and construction of the far detector was started at Kamioka. In 2021, the excavation of the access tunnel and initial mass production of the newly developed 20-inch PMTs was also started. In this paper, we present a basic overview of the project and the latest updates on the construction status of the project, which is expected to commence operation in 2027

Prospects for neutrino astrophysics with Hyper-Kamiokande

Hyper-Kamiokande is a multi-purpose next generation neutrino experiment. The detector is a two-layered cylindrical shape ultra-pure water tank, with its height of 64 m and diameter of 71 m. The inner detector will be surrounded by tens of thousands of twenty-inch photosensors and multi-PMT modules to detect water Cherenkov radiation due to the charged particles and provide our fiducial volume of 188 kt. This detection technique is established by Kamiokande and Super-Kamiokande. As the successor of these experiments, Hyper-K will be located deep underground, 600 m below Mt. Tochibora at Kamioka in Japan to reduce cosmic-ray backgrounds. Besides our physics program with accelerator neutrino, atmospheric neutrino and proton decay, neutrino astrophysics is an important research topic for Hyper-K. With its fruitful physics research programs, Hyper-K will play a critical role in the next neutrino physics frontier. It will also provide important information via astrophysical neutrino measurements, i.e., solar neutrino, supernova burst neutrinos and supernova relic neutrino. Here, we will discuss the physics potential of Hyper-K neutrino astrophysics

Programa de mejora genética de la raza bovina parda de montaña

La Raza Parda de Montaña es una raza de reciente reconocimiento oficial. En 2002, el Ministerio de Agricultura, Pesca y Alimentación mediante la Orden 33/2002, modificaba el Catálogo Oficial de razas de Ganado de España, incluyendo a la Parda de Montaña en el apartado de Razas españolas. Posteriormente, a principios del año 2004, el MAPA, publicó la Reglamentación Específica del Libro Genealógico de la raza a través de la Orden APA 17/2004, de 7 de enero, aprobándose el prototipo racial e iniciándose el proceso de apertura del Libro Fundacional.Publishe

Estimación de parámetros genéticos del peso al nacimiento, peso al destete, ganancia diaria nacimiento-destete y tres caracteres morfológicos en ganado vacuno de raza charolesa en España

Genetic parameters were estimated using REML in a multiple-trait animal model including genetic direct and maternal effects for birth and weaning weights, pre-weaning daily weight gain and three linearly scored traits (muscularity, skeletal size and general appearance) in 3,428 Charolais calves. The three complex type traits were scored at weaning on a nine-point scale. Fixed effects considered were herd-year-season of birth, sex of the calf and parity number of the dam. The fixed effect of weaning season and the linear covariate of age at weaning were considered for all variables except for birth weight. All fixed effects contributed significantly (P < 0.001) to variations in all traits except for the effect of weaning season which was not significant for the general appearance score. The percentage of variance explained by the model averaged 50.74% for the considered traits. Average birth and weaning weights and pre-weaning daily weight gain were 42.95, 278.21 and 1.11 kg, respectively, while muscularity, skeletal size and general appearance scores averaged 5.33, 5.19 and 5.36, respectively. Direct heritability estimates were 0.36, 0.36, 0.22, 0.50, 0.52 and 0.52 for the six traits, respectively. The corresponding maternal heritabilities were 0.37, 0.32, 0.18, 0.18, 0.15 and 0.13, respectively. Direct genetic correlations among these traits varied from low and negative (0.11) between birth and weaning weights to extremely high and positive (0.95) between muscularity and skeletal size scores. Type traits can be effectively used to improve the efficiency of beef production for Charolais calves in Spain.Se han estimado los parámetros genéticos de los caracteres, peso el nacimiento, peso al destete, ganancia media diaria predestete, y tres caracteres morfológicos lineales (desarrollo muscular, desarrollo esquelético y aptitud funcional) en 3.428 terneros Charoleses usando REML en un modelo animal multicarácter, incluyendo efectos genéticos directos y maternos. Los tres caracteres de tipo fueron registrados en una escala lineal de uno a nueve puntos. Los efectos fijos considerados en el modelo son: rebaño-año-estación de parto, sexo del ternero y el número de parto de la vaca. Se consideró el efecto fijo estación de destete y la covariable edad al destete para todas las variables, excepto para el peso de nacimiento. Todos los efectos fijos fueron significativos (P < 0,001) en todas las variables, excepto el efecto estación de destete, que no fue significativo para el carácter aptitud funcional. El porcentaje de varianza explicada por el modelo fue en promedio el 50,74% para los caracteres estudiados. Las medias de los caracteres peso al nacimiento, peso al destete y ganancia media diaria predestete fueron 42,95, 278,21 y 1,11 kg respectivamente, mientras que la puntuación media para desarrollo muscular, desarrollo esquelético y aptitud funcional fue 5,33, 5,19 y 5,36, respectivamente. Las estimaciones de heredabilidad en el componente genético directo fueron 0,36, 0,36, 0,22, 0,50, 0,52 y 0,52 para los seis caracteres, respectivamente. Las heredabilidades correspondientes al componente genético maternal fueron 0,37, 0,32, 0,18, 0,18, 0,15 y 0,13, respectivamente. La correlación genética directa entre estos caracteres varió desde pequeña y negativa (0,11) entre el peso al nacimiento y peso al destete a elevada y positiva (0,95) entre desarrollo muscular y desarrollo esquelético. Los caracteres de tipo pueden ser utilizados con eficiencia como objetivo de selección en los programas de mejora genética de la raza charolesa en España