357 research outputs found
Efficient measurements, purification, and bounds on the mutual information
When a measurement is made on a quantum system in which classical information
is encoded, the measurement reduces the observers average Shannon entropy for
the encoding ensemble. This reduction, being the {\em mutual information}, is
always non-negative. For efficient measurements the state is also purified;
that is, on average, the observers von Neumann entropy for the state of the
system is also reduced by a non-negative amount. Here we point out that by
re-writing a bound derived by Hall [Phys. Rev. A {\bf 55}, 100 (1997)], which
is dual to the Holevo bound, one finds that for efficient measurements, the
mutual information is bounded by the reduction in the von Neumann entropy. We
also show that this result, which provides a physical interpretation for Hall's
bound, may be derived directly from the Schumacher-Westmoreland-Wootters
theorem [Phys. Rev. Lett. {\bf 76}, 3452 (1996)]. We discuss these bounds, and
their relationship to another bound, valid for efficient measurements on pure
state ensembles, which involves the subentropy.Comment: 4 pages, Revtex4. v3: rewritten and reinterpreted somewha
High-voltage-activated Ca2+ currents and the excitability of pyramidal neurons in the hippocampal CA3 subfield in rats depend on corticosterone and time of day
This study tested the time-of-day dependence of the intrinsic postsynaptic properties of hippocampal CA3 pyramidal neurons. High-voltage-activated Ca2+ currents and the Ca2+- and voltage-dependent afterhyperpolarizations were examined in slices of rat brains obtained at four distinct time periods. Just after onset of the dark phase, the steady-state amplitude of the Ca2+ current (-1.24 ± 0.11 nA) was significantly greater (P < 0.03) than that of the light phase (-0.84 ± 0.06 nA). Over the entire time range, the amplitude of the Ca2+ current correlated with plasma corticosterone levels in a U-shaped function. Furthermore, depolarization-induced excitability during the dark phase exhibited an increased spike after depolarization (3.1 ± 0.1 mV) and a slower adaptation of the firing frequency (146 ± 18%). These findings point to a dynamic time-of-day dependence of the CA3 neuronal properties and postsynaptic Ca2+ currents.
Phase covariant quantum cloning
We consider an N -> M quantum cloning transformation acting on pure two-level
states lying on the equator of the Bloch sphere. An upper bound for its
fidelity is presented, by establishing a connection between optimal phase
covariant cloning and phase estimation. We give the explicit form of a cloning
transformation that achieves the bound for the case N=1, M=2, and find a link
between this case and optimal eavesdropping in the quantum cryptographic scheme
BB84.Comment: 9 pages, 1 figur
Reality, measurement and locality in Quantum Field Theory
It is currently believed that the local causality of Quantum Field Theory
(QFT) is destroyed by the measurement process. This belief is also based on the
Einstein-Podolsky-Rosen (EPR) paradox and on the so-called Bell's theorem, that
are thought to prove the existence of a mysterious, instantaneous action
between distant measurements. However, I have shown recently that the EPR
argument is removed, in an interpretation-independent way, by taking into
account the fact that the Standard Model of Particle Physics prevents the
production of entangled states with a definite number of particles. This result
is used here to argue in favor of a statistical interpretation of QFT and to
show that it allows for a full reconciliation with locality and causality.
Within such an interpretation, as Ballentine and Jarret pointed out long ago,
Bell's theorem does not demonstrate any nonlocality.Comment: 15 pages. Published versio
Complementarity and the uncertainty relations
We formulate a general complementarity relation starting from any Hermitian
operator with discrete non-degenerate eigenvalues. We then elucidate the
relationship between quantum complementarity and the Heisenberg-Robertson's
uncertainty relation. We show that they are intimately connected. Finally we
exemplify the general theory with some specific suggested experiments.Comment: 9 pages, 4 figures, REVTeX, uses epsf.sty and multicol.st
Synthesis of 1,2-benzisoxazole tethered 1,2,3-triazoles that exhibit anticancer activity in acute myeloid leukemia cell lines by inhibiting histone deacetylases, and inducing p21 and tubulin acetylation
1,2,3-Triazole-based heterocycles have previously been shown to possess significant anticancer activity in various tumor models. In the present study, we attached a 1,2,3-triazole moiety to the third position of a 1,2-benzisoxazole heterocycle via copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) with various alkynes and established for the title compounds significant antiproliferative effect against human acute myeloid leukemia (AML) cells. Among the tested compounds, 3-(4-(4-phenoxyphenyl)-1H-1,2,3-triazol-1-yl)benzodisoxazole (PTB) was found to be the most potent antiproliferative agent with an IC50 of 2 μM against MV4-11 cells using MTT assay. Notably, PTB induced cytotoxicity in MOLM13, MOLM14 and MV4-11 cells with selectivity over normal bone marrow cells (C57BL/6). Furthermore, PTB was found to induce cytotoxicity by increasing apoptosis of AML cells (MOLM13, MOLM14 and MV4-11) as well as sub-G1 cell population and apoptotic cells at submicromolar concentrations, as shown by flow cytometry and Annexin-V staining, respectively. On the protein level we suggested histone deacetylases (HDACs) as the potential protein target of those compounds in silico, and the predicted target was next experimentally validated by measuring the variations in the levels of p21, cyclin D and acetylation of histone H3 and tubulin. Molecular docking analysis of the title compounds with the second deacetylase domain of HDAC6 displayed high degree of shape complementarity to the binding site of the enzyme, forming multiple molecular interactions in the hydrophobic region as well as a hydrogen bond to the phenol side-chain of Tyr-782. Thus, 1,2,3-triazole derivatives appear to represent a class of novel, biologically active ligands against histone deacetylases which deserve to be further evaluated in their applications in the cancer field. © 2015 Elsevier Ltd. All rights reserved
Universal geometric approach to uncertainty, entropy and information
It is shown that for any ensemble, whether classical or quantum, continuous
or discrete, there is only one measure of the "volume" of the ensemble that is
compatible with several basic geometric postulates. This volume measure is thus
a preferred and universal choice for characterising the inherent spread,
dispersion, localisation, etc, of the ensemble. Remarkably, this unique
"ensemble volume" is a simple function of the ensemble entropy, and hence
provides a new geometric characterisation of the latter quantity. Applications
include unified, volume-based derivations of the Holevo and Shannon bounds in
quantum and classical information theory; a precise geometric interpretation of
thermodynamic entropy for equilibrium ensembles; a geometric derivation of
semi-classical uncertainty relations; a new means for defining classical and
quantum localization for arbitrary evolution processes; a geometric
interpretation of relative entropy; and a new proposed definition for the
spot-size of an optical beam. Advantages of the ensemble volume over other
measures of localization (root-mean-square deviation, Renyi entropies, and
inverse participation ratio) are discussed.Comment: Latex, 38 pages + 2 figures; p(\alpha)->1/|T| in Eq. (72) [Eq. (A10)
of published version
Ferromagnetism in Oriented Graphite Samples
We have studied the magnetization of various, well characterized samples of
highly oriented pyrolitic graphite (HOPG), Kish graphite and natural graphite
to investigate the recently reported ferromagnetic-like signal and its possible
relation to ferromagnetic impurities. The magnetization results obtained for
HOPG samples for applied fields parallel to the graphene layers - to minimize
the diamagnetic background - show no correlation with the magnetic impurity
concentration. Our overall results suggest an intrinsic origin for the
ferromagnetism found in graphite. We discuss possible origins of the
ferromagnetic signal.Comment: 11 figure
Detecting Physics At The Post-GUT And String Scales By Linear Colliders
The ability of linear colliders to test physics at the post-GUT scale is
investigated. Using current estimates of measurements available at such
accelerators, it is seen that soft breaking masses can be measured with errors
of about (1-20)%. Three classes of models in the post-GUT region are examined:
models with universal soft breaking masses at the string scale, models with
horizontal symmetry, and string models with Calabi-Yau compactifications. In
each case, linear colliders would be able to test directly theoretical
assumptions made at energies beyond the GUT scale to a good accuracy,
distinguish between different models, and measure parameters that are expected
to be predictions of string models.Comment: Latex, 21 pages, no figure
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