The Role of a Condominium’s Association in Adapting, Complying, and Self-Reducing Anxiety in Response to COVID-19 Precautionary Measures

Our article is part of a micro-inquiry into the small reality of co-ownership to formulate hypotheses on the evaluation of behaviors (non-pharmaceutical precautionary measures) in addition to pharmaceutical actions put in place by the authorities against future pandemics. Our article takes its first steps in the fact that one of the most common ways to fight the COVID-19 virus is to avoid close contact between people. Indeed, our condominium meetings have been canceled at the first COVID-19 vague (in late February 2020), and social distancing as well as the use of masks and hand sanitizer in the concierge are measures still adopted at the end of 2022. External people (parents, visitors in general, and patients from the three health offices housed in the condominium) have been reduced, and certain businesses, such as bed and breakfasts, which were operating until 2019, had been closed following the first vague of COVID-19 pandemics. The general condominium association has been centralized under the conscious direction of the doorman led by the administrator of the condominium and a support lawyer. Stray animals at the foot of the condominium and fed by a couple of residents have been reduced to the strict minimum. On a sample of 39 people questioned and from an age range between 17 and 93 years, actually residing in the condominium and excluding those members of families who do not actually reside there, we inquired how the risk of COVID-19 infection has decreased over the past year (December 2021-December 2022). The useful variables to determine the correlations between the precautionary behaviors adopted by the co-owners and a possible reduction in the risk of infection are: 1) size of the family (self-observed); 2) level of education (self-observed); 3) professional status (self-observed); 4) salary (self-observed); 5) travel history (self-observed); 6) annual charity (self-observed estimate); 7) confidence in sustainability (interviews via mobile chat); 8) doses of vaccines already taken to the time of the survey (interviews via mobile chat); and 9) depressive symptoms (interviews via mobile chat). Our survey targets to highlight how residents’ safety in the case of one of the most recent periods of COVID-19 pandemics—i. e. the starting winter season 2022‒2023—is somehow safeguarded by cooperative games because of condominiums rules’ fulfillment as well as by socio-juridical precautionary measures taken by the ruling association

Evolving Sustainable Material Culture (SMC): Emerging Trends and Strategic Implications for Green Finance

This paper examines the integration of Sustainable Material Culture (SMC) within the Green Finance (GF) framework, focusing on decision-making strategies inspired by game theory, inference rules, and advanced financial modeling to support sustainable economic principles. Since the 2008 financial crisis, traditional investment strategies have increasingly sought alignment with long-term sustainability goals. However, they inherently carry risks when adapting to the evolving complexities of environmental challenges, such as biodiversity loss, climate change, and infrastructure inequity. SMC is defined here as the material objects, practices, and frameworks reflecting human efforts to promote sustainability, driven by individual and collective investments. Our analysis identifies significant challenges in GF, such as the dual roles of investors as contributors to and beneficiaries of SMC, alongside the application of advanced decision-making frameworks, including Pareto efficiency and Bayesian-Nash equilibrium, to support these roles effectively. We explore how GF initiatives, exemplified by global sustainable finance instruments, address (and sometimes struggle to meet) the multidimensional requirements of SMC. We illustrate how these investments foster economic transformation and resilience by building on case studies of innovative GF initiatives—including sovereign green bond issuances, community-led projects, and energy transition programs in emerging markets. Nuanced trade-offs between commissions and omissions by stakeholders highlight the ethical challenges in designing and promoting sustainable financial products

Oral necrotizing microvasculitis in a patient affected by Kawasaki disease

Kawasaki disease (KD) was first described in 1967 by Kawasaki, who defined it as ?mucocutaneous lymph node syndrome?. KD is an acute systemic vasculitis, which mainly involves medium calibre arteries; its origin is unknown, and it is observed in children under the age of 5, especially in their third year. The principal presentations of KD include fever, bilateral nonexudative conjunctivitis, erythema of the lips and oral mucosa, changes in the extremities, rash, and cervical lymphadenopathy. Within KD, oral mucositis ? represented by diffuse mucous membrane erythema, lip and tongue reddening and lingual papillae hypertrophy with subsequent development of strawberry tongue ? can occur both in the acute stage of the disease (0-9 days), and in the convalescence stage (>25 days) as a consequence of the pharmacological treatment. KD vascular lesions are defined as systemic vasculitis instead of systemic arteritis. This study analyzed the anatomical-pathological substrata of oral mucositis in a baby affected by Kawasaki disease and suddenly deceased for cardiac tamponade caused by coronary aneurysm rupture (sudden cardiac death of a mechanical type)

Ascites and resistance to immune checkpoint inhibition in dMMR/MSI-H metastatic colorectal and gastric cancers

Gastrointestinal neoplasms; Immunotherapy; Tumor biomarkersNeoplasias gastrointestinales; Inmunoterapia; Biomarcadores tumoralesNeoplàsies gastrointestinals; Immunoteràpia; Biomarcadors tumoralsBackground Despite unprecedented benefit from immune checkpoint inhibitors (ICIs) in patients with mismatch repair deficient (dMMR)/microsatellite instability high (MSI-H) advanced gastrointestinal cancers, a relevant proportion of patients shows primary resistance or short-term disease control. Since malignant effusions represent an immune-suppressed niche, we investigated whether peritoneal involvement with or without ascites is a poor prognostic factor in patients with dMMR/MSI-H metastatic colorectal cancer (mCRC) and gastric cancer (mGC) receiving ICIs. Methods We conducted a global multicohort study at Tertiary Cancer Centers and collected clinic-pathological data from a cohort of patients with dMMR/MSI-H mCRC treated with anti-PD-(L)1 ±anti-CTLA-4 agents at 12 institutions (developing set). A cohort of patients with dMMR/MSI-high mGC treated with anti-PD-1 agents±chemotherapy at five institutions was used as validating dataset. Results The mCRC cohort included 502 patients. After a median follow-up of 31.2 months, patients without peritoneal metastases and those with peritoneal metastases and no ascites had similar outcomes (adjusted HR (aHR) 1.15, 95% CI 0.85 to 1.56 for progression-free survival (PFS); aHR 0.96, 95% CI 0.65 to 1.42 for overall survival (OS)), whereas inferior outcomes were observed in patients with peritoneal metastases and ascites (aHR 2.90, 95% CI 1.70 to 4.94; aHR 3.33, 95% CI 1.88 to 5.91) compared with patients without peritoneal involvement. The mGC cohort included 59 patients. After a median follow-up of 17.4 months, inferior PFS and OS were reported in patients with peritoneal metastases and ascites (aHR 3.83, 95% CI 1.68 to 8.72; aHR 3.44, 95% CI 1.39 to 8.53, respectively), but not in patients with only peritoneal metastases (aHR 1.87, 95% CI 0.64 to 5.46; aHR 2.15, 95% CI 0.64 to 7.27) when compared with patients without peritoneal involvement. Conclusions Patients with dMMR/MSI-H gastrointestinal cancers with peritoneal metastases and ascites should be considered as a peculiar subgroup with highly unfavorable outcomes to current ICI-based therapies. Novel strategies to target the immune-suppressive niche in malignant effusions should be investigated, as well as next-generation ICIs or intraperitoneal approaches

Clinical correlates of emotion dysregulation in Down syndrome: a comparative study

IntroductionEmotion regulation is crucial for mental health and adaptive psychological functioning. Despite growing interest in emotion dysregulation (ED) in individuals with intellectual disability (ID), little is known about its association with neuropsychological and psychopathological profiles in children and adolescents with Down syndrome (DS), the most frequent genetic cause of ID. This study aimed to compare the neuropsychological profile, psychopathological symptoms, and sleep disturbances of children with DS with and without ED.MethodsData were retrospectively collected from a database. The final sample included 214 participants (6–18 years): 69 with co-occurring ED and 145 controls without ED, with groups balanced for age and sex. Emotional/behavioral difficulties and sleep problems were assessed through parent-report questionnaires and clinical interviews. Language abilities and visual-motor integration skills were evaluated by standardized tests.ResultsChildren with co-occurring ED exhibited significantly worse visual-integration and motor coordination skills than children without co-occurring ED. Moreover, they displayed more psychopathological symptoms ascribable to both externalizing and internalizing problems. Finally, children with ED exhibited more sleep difficulties associated with insomnia and parasomnias.ConclusionThese results emphasize the need to consider ED in assessment and interventions, as it can significantly impact neuropsychological development and overall wellbeing

Analisi statistica dei casi di intossicazione rilevati al Pronto Soccorso dell'Ospedale dei Bambini G. di Cristina di Palermo nel periodo 2011-2015

Lo Studio affronta l'incidenza dei casi di intossicazione riscontrati, nel periodo 2011- 2015 , presso l'Ospedale dei Bambini G. di Cristina di Palermo. Lo scopo è di identificare gli agenti eziologici più frequenti e la relativa incidenza nel periodo preso in esame

Epidemiological assessment of Respiratory Syncytial Virus infection in hospitalized infants, during the season 2005–2006 in Palermo, Italy

<p>Abstract</p> <p>Objectives</p> <p>Respiratory Syncytial Virus (RSV) is the leading cause of hospitalization for lower respiratory tract infections (LRTI) in young children worldwide.</p> <p>We evaluate the epidemiological and clinical patterns of RSV infection in infants hospitalized for LRTI in in Palermo, South Italy, Sicily.</p> <p>Methods</p> <p>We collected the demographic details of infants hospitalized to G. Di Cristina Children's Hospital in Palermo for LRTI between November 2005 and May 2006. We also included all cases occurred in newborns hospitalized in the Neonatal Intensive Care Unit (NICU) Of Palermo.</p> <p>Results</p> <p>During the studied period, 335/705 hospitalized infants for LRTI were enrolled in the study. The trend of hospitalization started in late winter and lasting until May 2006 with an epidemic peak in spring. 178/335 infants tested for viral infection showed RSV disease. Three cases occurred in preterm newborns hospitalized from birth in NICU. The likelihood to be RSV+, rather than RSV negative (RSV-) was higher for infants < 6 months and lower for infants with history of breast feeding (P < 0.05). RSV infection was associated with a higher likelihood to be admitted to intensive care unit and to a longer hospitalization and oxygen therapy.</p> <p>Conclusion</p> <p>The study shows that, in Sicily, RSV is an important cause of LRTI in infants. The seasonal distribution shows that both LRTI and RSV infections peak in late spring, in contrast to Northern Italy. Our data could help to define the regional appropriate start of prophylactic interventions.</p

Pharmacogenomic evaluation of single nucleotide polymorphisms associated with oxaliplatin-induced peripheral neuropathy: a preliminary study

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