On Rational Response of Criminal Law to a “Risk Society”

Currently, on the basis of a generalized understanding of “ Risk Society Theory” by Ulrich Beck, the notion of responding to “risk society” through expanding criminal legislation and judicature to attain risk control and prevention is put forward by Chinese scholars. This notion, however, will definitely break through the traditional concept of culpability and shake the foundation of traditional criminal law in such respects as legal interests infringement, causal relationship and doctrine of liability fixation, leading to a risk in criminal law application. In consequence, the priority now is to truly grasp the definition of “risk society” and rationally deal with social risks. In the face of risk, the criminal law shall not only face up it, but also rationally strike a balance between risk prevention and protection of human rights, scrupulously abiding by the fundamental philosophy of criminal law

Users’ Perception and Utility of Health Information Based on WeChat

Objective: To explore the ability of users to identify the health information spread on WeChat platform, and then to discuss the utility of such information on them. Methods: Questionnaire survey and descriptive statistical methods were used to collect and analyze the data. The process of “get health related information, judge true or false, production related behavior” was used to design the survey problem, finally, the paper and network surveys were investigated in users. Results: The proportion of accurate recognition, ambiguous recognition, none recognition and none classification were 21.55%, 63.26%, 4.41%, 10.78% respectively. The average frequency of identification, transmission, guidance and none behavior of originally true health information were 52.00, 78.40, 45.20, 31.80 respectively, and originally false health information were 21.30, 27.70, 14.10, 5.50 respectively.Conclusions: Most WeChat users surveyed lack the ability to accurately identify the authenticity of health information, and improvement of citizens’ health literacy has long way to go. WeChat is an effective platform for the dissemination of health information, but also provides a fertile soil for the spread of false health information. Additionally, users are not aware of the problem of their ability to identify information, even if produced a false judgment of false health information, most of the active users will also lead this kind of information still widely spread

RiskVis: Supply chain visualization with risk management and real-time monitoring

Agency for Science, Technology and Research (A*STAR

Garnierite mineralization from a serpentinite-derived lateritic regolith, Sulawesi Island, Indonesia: Mineralogy, geochemistry and link to hydrologic flow regime

Garnierite represents a significant nickel ore in many lateritic Ni deposits worldwide. To gain a better understanding of its nature and origin, a well-developed garnierite-hosting transect from the Kolonodale area of East Sulawesi, Indonesia, has been investigated using field geology, mineralogy and geochemical data. Garnierite occurs mainly in veins in the lower saprolite of a serpentinite-derived regolith. Mineralogically, it can be determined as an intimate mixture of Ni-rich serpentine-like (lizardite-Nepouite) and talc-like (kerolite-pimelite) phases. Results of EMP analyses indicate that Ni is preferentially enriched in the talc-like phases rather than the serpentine-like phases. A sequential precipitation of mineral phases progressively enriched in Ni and Si to form garnierite during weathering is suggested. The Ni-lizardite (2.63-8.49 wt% Ni) with elevated Fe (4.02-6.44 wt %) may have been inherited from saprolite in a first instance and enriched in Ni by cation exchange processes. Newly precipitated minerals are kerolite-pimelite (7.84-23.54 wt% Ni) and then followed by Ni-free quartz. Minor amount of Nepouite (23.47-28.51 wt% Ni) occur in laths along shrinkage cracks of previously formed minerals, indicating a late stage paragenetic sequence. With emphasis on a hydrologic consideration, indicators of a preferential flow regime are identified in the garnierite-hosting regolith, including: (i) non-uniform pattern of the garnierite field occurrence, (ii) syn-weathering active nature of the garnierite-hosting structures, (iii) close relationship between the garnierite occurrence and vertical FeeMn oxides pipes as well as FeeMn oxides patched areas, and (iv) specific physico-chemical property of the garnierite location with higher organic matter concentrations but lower pH values compared to surroundings. It is proposed that the origin of garnierite is closely linked to a preferential flow of oversaturated solutions through accessible conduits in the regolith. Garnierite features as colloidal nature, high organic matter and low pH are key-parameters in metal transport and deposition

Elevated TCA cycle function in the pathology of diet-induced hepatic insulin resistance and fatty liver

The manner in which insulin resistance impinges on hepatic mitochondrial function is complex. Although liver insulin resistance is associated with respiratory dysfunction, the effect on fat oxidation remains controversial, and biosynthetic pathways that traverse mitochondria are actually increased. The tricarboxylic acid (TCA) cycle is the site of terminal fat oxidation, chief source of electrons for respiration, and a metabolic progenitor of gluconeogenesis. Therefore, we tested whether insulin resistance promotes hepatic TCA cycle flux in mice progressing to insulin resistance and fatty liver on a high-fat diet (HFD) for 32 weeks using standard biomolecular and in vivo (2)H/(13)C tracer methods. Relative mitochondrial content increased, but respiratory efficiency declined by 32 weeks of HFD. Fasting ketogenesis became unresponsive to feeding or insulin clamp, indicating blunted but constitutively active mitochondrial β-oxidation. Impaired insulin signaling was marked by elevated in vivo gluconeogenesis and anaplerotic and oxidative TCA cycle flux. The induction of TCA cycle function corresponded to the development of mitochondrial respiratory dysfunction, hepatic oxidative stress, and inflammation. Thus, the hepatic TCA cycle appears to enable mitochondrial dysfunction during insulin resistance by increasing electron deposition into an inefficient respiratory chain prone to reactive oxygen species production and by providing mitochondria-derived substrate for elevated gluconeogenesis

Defect and strain in hydrogen and helium coimplanted single-crystal silicon

In this paper we studied the processes of blistering and exfoliation on the surface of crystal silicon, the evolution of defects/strains in the crystal silicon caused by hydrogen and helium coimplantation during annealing, and the formation of platelets and bubbles in the crystal. It is shown that H + and He + coimplantation produces a synergistic effect, which greatly decreases the total implantation dose, compared with either just H + or He + implantation. We also present the effect of coimplantation and analyse the different roles of H and He in the process of exfoliation during annealing. It seems that the essential role of hydrogen is to interact chemically with the defects in the silicon and create H-stabilized platelets, while the role of helium is to effuse into these platelets and exert a pressure on the inner surface of these platelets. The damage caused by coimplantation is lower than by hydrogen implantation (at the dose that exfoliation requires).Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/48907/2/d10102.pd

A novel class of microRNA-recognition elements that function only within open reading frames.

MicroRNAs (miRNAs) are well known to target 3' untranslated regions (3' UTRs) in mRNAs, thereby silencing gene expression at the post-transcriptional level. Multiple reports have also indicated the ability of miRNAs to target protein-coding sequences (CDS); however, miRNAs have been generally believed to function through similar mechanisms regardless of the locations of their sites of action. Here, we report a class of miRNA-recognition elements (MREs) that function exclusively in CDS regions. Through functional and mechanistic characterization of these 'unusual' MREs, we demonstrate that CDS-targeted miRNAs require extensive base-pairing at the 3' side rather than the 5' seed; cause gene silencing in an Argonaute-dependent but GW182-independent manner; and repress translation by inducing transient ribosome stalling instead of mRNA destabilization. These findings reveal distinct mechanisms and functional consequences of miRNAs that target CDS versus the 3' UTR and suggest that CDS-targeted miRNAs may use a translational quality-control-related mechanism to regulate translation in mammalian cells

Mesenchymal Stem Cell Migration and Tissue Repair

Mesenchymal stem cells (MSCs) are multilineage cells with the ability to self-renew and differentiate into a variety of cell types, which play key roles in tissue healing and regenerative medicine. Bone marrow-derived mesenchymal stem cells (BMSCs) are the most frequently used stem cells in cell therapy and tissue engineering. However, it is prerequisite for BMSCs to mobilize from bone marrow and migrate into injured tissues during the healing process, through peripheral circulation. The migration of BMSCs is regulated by mechanical and chemical factors in this trafficking process. In this paper, we review the effects of several main regulatory factors on BMSC migration and its underlying mechanism; discuss two critical roles of BMSCs—namely, directed differentiation and the paracrine function—in tissue repair; and provide insight into the relationship between BMSC migration and tissue repair, which may provide a better guide for clinical applications in tissue repair through the efficient regulation of BMSC migration

A high gain, noise cancelling 2515-4900 MHz CMOS LNA for China mobile 5G communication application

© 2020 Tech Science Press. All rights reserved. With the development of the times, people\u27s requirements for communication technology are becoming higher and higher. 4G communication technology has been unable to meet development needs, and 5G communication technology has emerged as the times require. This article proposes the design of a low-noise amplifier (LNA) that will be used in the 5G band of China Mobile Communications. A low noise amplifier for mobile 5G communication is designed based on Taiwan Semiconductor Manufacturing Company (TSMC) 0.13 μm Radio Frequency (RF) Complementary Metal Oxide Semiconductor (CMOS) process. The LNA employs self-cascode devices in current-reuse configuration to enable lower supply voltage operation without compromising the gain. This design uses an active feedback amplifier to achieve input impedance matching, avoiding the introduction of resistive negative feedback to reduce gain. A common source (CS) amplifier is used as the input of the low noise amplifier. In order to achieve the low power consumption of LNA, current reuse technology is used to reduce power consumption. Noise cancellation techniques are used to eliminate noise. The simulation results in a maximum power gain of 22.783, the reverse isolation (S12) less than -48.092 dB, noise figure (NF) less than 1.878 dB, minimum noise figure (NFmin)=1.203 dB, input return loss (S11) and output return loss (S22) are both less than -14.933 dB in the frequency range of 2515-4900 MHz. The proposed Ultra-wideband (UWB) LNA consumed 1.424 mW without buffer from a 1.2 V power supply