Measurement of the ratios of branching fractions R(D∗)\mathcal{R}(D^{*}) and R(D0)\mathcal{R}(D^{0})

The ratios of branching fractions $\mathcal{R}(D^{*})\equiv\mathcal{B}(\bar{B}\to D^{*}\tau^{-}\bar{\nu}_{\tau})/\mathcal{B}(\bar{B}\to D^{*}\mu^{-}\bar{\nu}_{\mu})$ and $\mathcal{R}(D^{0})\equiv\mathcal{B}(B^{-}\to D^{0}\tau^{-}\bar{\nu}_{\tau})/\mathcal{B}(B^{-}\to D^{0}\mu^{-}\bar{\nu}_{\mu})$ are measured, assuming isospin symmetry, using a sample of proton-proton collision data corresponding to 3.0 fb${ }^{-1}$ of integrated luminosity recorded by the LHCb experiment during 2011 and 2012. The tau lepton is identified in the decay mode $\tau^{-}\to\mu^{-}\nu_{\tau}\bar{\nu}_{\mu}$. The measured values are $\mathcal{R}(D^{*})=0.281\pm0.018\pm0.024$ and $\mathcal{R}(D^{0})=0.441\pm0.060\pm0.066$, where the first uncertainty is statistical and the second is systematic. The correlation between these measurements is $\rho=-0.43$. Results are consistent with the current average of these quantities and are at a combined 1.9 standard deviations from the predictions based on lepton flavor universality in the Standard Model.Comment: All figures and tables, along with any supplementary material and additional information, are available at https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-039.html (LHCb public pages

“Being Flexible”: Graduates Facing Changes in Their Work Environment

According to the crucial importance of innovation for modern economies, the role of graduates regarding innovation appears to be a major topic when their performances in the labour market at stake. Five main questions are addressed in this chapter: (1) What does innovation mean? (2) Which organisations are likely to be more innovative? (3) What role do Higher Education graduates play regarding innovation? (4) Are they equipped to do develop innovation? (5) Which are the occupations more related to innovation, and are innovative activities rewarded? The results presented in this chapter confirm that higher education graduates are crucial actors in the innovation process. The jobs of innovative graduates show a number of specific characteristics: a high level of autonomy, more leeway to define their own goals and to perform their tasks. A paradox that emerged is the following: although innovation is more strongly developed in large organisations, small organisations offer graduates more opportunities to play a role in introducing innovations. When earnings are considered, innovative activities appear to be rewarded, in the private sector. That confirms the impression that innovation is recognised as valuable by organisations

Liposomes containing mannose-6-phosphatecholesteryl conjugates for lysosome-specific delivery

Lysosomes are promising targets for cancer and enzyme replacement therapy. In this area of interest we present a novel liposomal nanocarrier containing mannose 6-phosphate-cholesteryl conjugates and show its ability to reach the lysosomes by means of confocal and fluorescence microscopy measurement

A 4D-tracker demonstrator based on the Timespot1, a CMOS 28-nm ASIC

The Timespot1 ASIC was developed using 28-nm CMOS technology within the TimeSPOT/IGNITE collaborations and aimed to bridge the gap between available fast-timing ASICs and those required for high-luminosity applications. We present results of the performance of the Timespot1 hybrid, where 3D trench silicon and 3D columnar diamond sensors have been bump-bonded to the Timespot1 ASIC

Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps

Large-scale whole-genome sequence data sets offer novel opportunities to identify genetic variation underlying human traits. Here we apply genotype imputation based on whole-genome sequence data from the UK1OK and 1000 Genomes Project into 35,981 study participants of European ancestry, followed by association analysis with 20 quantitative cardiometabolic and hematological traits. We describe 17 new associations, including 6 rare (minor allele frequency (MAF) <1 %) or low-frequency (1% <MAF <5%) variants with platelet count (PLT), red blood cell indices (MCH and MCV) and HDL cholesterol. Applying fine-mapping analysis to 233 known and new loci associated with the 20 traits, we resolve the associations of 59 loci to credible sets of 20 or fewer variants and describe trait enrichments within regions of predicted regulatory function. These findings improve understanding of the allelic architecture of risk factors for cardiometabolic and hematological diseases and provide additional functional insights with the identification of potentially novel biological targets

Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps

Large-scale whole-genome sequence data sets offer novel opportunities to identify genetic variation underlying human traits. Here we apply genotype imputation based on whole-genome sequence data from the UK10K and 1000 Genomes Project into 35,981 study participants of European ancestry, followed by association analysis with 20 quantitative cardiometabolic and hematological traits. We describe 17 new associations, including 6 rare (minor allele frequency (MAF) < 1%) or low-frequency (1% < MAF < 5%) variants with platelet count (PLT), red blood cell indices (MCH and MCV) and HDL cholesterol. Applying fine-mapping analysis to 233 known and new loci associated with the 20 traits, we resolve the associations of 59 loci to credible sets of 20 or fewer variants and describe trait enrichments within regions of predicted regulatory function. These findings improve understanding of the allelic architecture of risk factors for cardiometabolic and hematological diseases and provide additional functional insights with the identification of potentially novel biological targets

Erratum to: Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps

In the version of the article published, the surname of author Aaron Isaacs is misspelled as Issacs