Transformations in socio-economic development of the Gulf group states

The article is devoted to the national economy transformations of the GCC States (Cooperation Council for the Arab States of the Gulf countries). This paper analyzes the dynamics of socio-economic development of the Gulf Group countries for the last 10 years, compares and systematizes the traditional and unique statistical data in order to prove the hypothesis that the positive dynamics was not only due to the high hydrocarbon prices on the global market but also to the successful structural transformation. The growth of the regional economy in the conditions of an almost threefold drop in world oil prices over the past three years is shown. We use systemic approach, comparative and statistical analysis. As the analysis of economic situation and development in the GCC countries at the current stage shows, all of them need to change the structure of the national economy and diversify it in order to reduce the dependence from mining industries, world prices fluctuations. This paper proposes a number of practical considerations and appropriate measures for the formation of more rational structure of the national economies, including the diversification of the sources of budget revenues through expanding industrialization; accelerating development of solid minerals and the creation of new industries using them. As Gulf States belong to the group of emerging countries and the structure of their national economies is similar with the Russian economy, the factors of the positive changes of the national economies will be useful for Russian and foreign researchers

The impact of regionalism on regional development under the conditions of a globalized economy

The aim of this article is to explain the difference between regionalism and regional development concepts that are often used interchangeably, to investigate the fundamental aspects of two phenomena: regionalism in the sense of "new regionalism" and in the sense of "regional development" at the background of the globalized economy; to check a hypothesis that these two phenomena may be linked together and to study the impact of regionalism on regional integration. The article deepens the concept of "regional development." At the same time, peculiarities of the current stage of the world economy development under the conditions of globalization are considered. The paper is theoretical (verbal) rather than statistical analysis of the nature, diversity and fundamental aspects of regionalism and regional development in general. The article deals with the impact of regionalism on the location of production, and the growth of competition and market expansion systematizes the main effects of regionalism on market expansion and the location of production. © Chihelkova E., Frolova E. D. Text. 2014

Comparative Analysis of Foreign Trade Development in the Digital Segment by World Regions

Foreign trade, affected by digitalisation, acquired new features, while its development led to a new redistribution of world regions. The present article aims to reveal specific features and emerging trends in the digital segment of foreign trade and identify leading regions and success factors. In this case, the digital segment includes ICT-equipment and ICT-services trade. UNCTAD statistics for 2000–2019 were examined using the methodology of foreign trade structural and comparative analysis. We hypothesise that there are different development stages in the digital segment of foreign trade characterised by changes of leading regions. In particular, three waves in the development of the digital segment of foreign trade, corresponding to different characteristics, were identified. In the third wave, the growth rate of digital turnover remained the same but its share in the total global turnover decreased. It was revealed that the share of the digital segment is higher than the share of merchandise trade in the countries of one region. Asia-Pacific Region replaced the USA (that moved from the 1st place in the first wave to the 5th position) as the leading region. China, specialising in the export of ICT-equipment, came out on top with the 27.1 % share of digital exports in the country’s total exports, increasing by 15.9 times in 20 years. Russia, whose specialisation is the export of ICT-services, is closer to the end of the top 50 ranking of countries in this segment; its negative foreign trade balance was also revealed. The obtained findings can be useful for specialists developing the foreign digital trade strategy of Russia. In order to increase the potential of national economies, including Russia, in the digital segment of foreign trade, further research should focus on ways to prevent their lagging behind the leaders. © 2022 Institute of Economics, Ural Branch of the Russian Academy of Sciences. All rights reserved

Marginal abatement cost curve for an ammonia reduction measure in agriculture: the case of Latvia

Received: January 28th, 2021 ; Accepted: May 26th, 2021 ; Published: August 24th, 2021 ; Correspondence: [email protected] the production of grain and livestock–derived agricultural commodities increasing, the agricultural sector has become one of the main sources of ammonia (NH3) emissions in Latvia. In 2018, the agricultural sector contributed to 83% of the total NH3 emissions originated in Latvia (15.46 kt) (LIIR 2020). The EU has already put in place measures to control NH3 emissions. This includes the EU target of reducing ammonia emissions by 21% by 2030 and sets out emission reduction commitments for Latvia. Considering Latvia’s indicative reduction target, the NH3 emission reductions need to be achieved by 2030 (Directive 2016/2284) so that the emissions do not exceed the 2005 level (11.33 kt). Implementing no mitigation measures, Latvia has projected agricultural sector NH3 emissions to be 32.4% higher than those in 2005, and therefore the mitigation of the NH3 emissions from agriculture is important. The research aims to estimate cost-effective NH3 emission reduction measures in agriculture in Latvia. The results of the research represent a marginal abatement cost curve (MACC) analysis, in which we have quantified the potential for reduction for selected NH3 emission mitigation measures in Latvia. A list of the measures has been established taking into account the experience of good agricultural practices in the reduction of NH3 emissions (UN, 2014) and of other European countries as well. The calculations carried out allowed us to group the measures according to their priorities: measures that are cost-effective and with high potential for reduction of NH3; measures that are cost-effective but with low NH3 emission reduction potential; measures that are not cost-effective but with high potential for reduction of NH3; measures that are not cost-effective and with low potential for reduction of NH3. The estimated cumulative (total) reduction of NH3 emissions in Latvian agriculture by 2030, with the implementation of the measures analysed, is equal to 20.08 kt

Organizational and economic transformations towards the greening of agro-industrial production

The increase in the production of agricultural products and food supplies in excess of regulatory needs and the provision of food safety in Russia led to the expansion of the export of agricultural products and the change in the course of the development of the agro-industrial complex from import substitution to export-oriented production. However, the entry to world food markets requires high quality of products from manufacturers and its certification in accordance with world standards. The article presents the organizational and economic transformations towards the greening of agro-industrial production, namely, the use of the resource potential, the involvement of Russian manufacturers in the production of environmentally friendly products and the development of organic agriculture; the mechanisms for solving the set problems are substantiated.peer-reviewe

TREATMENT OF TRIPLE-NEGATIVE BREAST CANCER

The rate of triple-negative breast cancer is 10–24  %, and in recent years it’s one of the most studied subtypes of breast cancer due to its clinical aggressiveness and a small number of molecular targets.The study objective is to evaluate effectiveness of different NAPCT regimens including their dependence on the presence of mutations in the ВRСА 1, 2, СHEK2 genes.Materials and methods. The study included 40 female patients with triple-negative breast cancer. The patients were monitored from 2012 to 2016; surgical treatment was performed at the P.A. Hertzen Moscow Oncology Research Institute – branch of the National Medical Research Radiological Center, Ministry of Health of Russia. Median patient age was 45.9 (31–69)  years. All patients received neoadjuvant polychemotherapy (NAPCT) per different regimens. Then the patients underwent surgery of different volume (from radical mastectomies to resections), and in 25 % of cases reconstructive breast surgery was performed. In 5 patients with BRCA1, – 2 mutations, prophylactic subcutaneous mastectomy with immediate reconstruction with an implant was performed; 2 patients refused prophylactic mastectomy; in 1 patient with СНЕК2 mutation, metachronous multiple primary breast cancer was diagnosed, previously she didn»t undergo prophylactic mastectomy, and 6 years later cancer in the second breast was diagnosed.Results. The study included 11 patients under 40 (27.5 %), 4 (50 %) of them in the group with mutations in ВRCA1, -2, CHEK2.The study demonstrated high effectiveness of NAPCT regimens per the АС + Т scheme and weekly injections of doxorubicin 25 mg/m2, cisplatin 30 mg/m2, and paclitaxel 100 mg/m2. Grade IV treatment pathomorphosis for NAPCT per АС + Т scheme was achieved in 50.0 ± 7.9 % cases, for intensified regimen – in 62.5 ± 12.5 % cases.Median follow-up duration for this patient group was 22.1 months, and during this time disease progression was observed in 3 patients: in the 1st patient continued growth on the thoracic wall and brain metastases were diagnosed, in the 2nd patient – lung and supraclavicular lymph nodes metastases, in the 3rd patient – metastases in the cerebellum. In all of these patients, grade IV treatment pathomorphosis wasn»t achieved. Conclusions. The study demonstrated high effectiveness of NAPCT in patients with triple-negative breast cancer of different stages: objective response rate was 90.0 ± 4.7 %, grade IV treatment pathomorphosis was 50.0 ± 7.9 %.Grade IV treatment pathomorphosis for NAPCT per АС + Т scheme was achieved in 50.0 ± 7.9 % cases, for intensified regimen – in 62.5 ± 12.5 % cases. Rate of grade IV treatment pathomorphosis was higher in patients with hereditary form of the disease (62.5 ± 18.3 %) compared to the group with sporadic breast cancer (46.9 ± 8.8 %), р >0.05. In all patients, 2-year disease-free survival was 92.5 %, 2-year overall survival was 95 %

Study of the physicochemical properties of dispersed aqueous toothpaste systems with sodium chloride and calcium glycerophosphate

To study the physicochemical properties of Dentaswiss Enamel Repair & Protect toothpaste, its aqueous extracts of various concentrations have been prepared. Their high electrical conductivity was established, which is due to the presence of a strong electrolyte - sodium chloride, as well as a significant amount of calcium 0.98-2.18 ± 0.01 mmol / l contained in the ionized state. It is this ionized calcium that is involved in the processes of mineralization of enamel when using this toothpaste. The high concentration of salts in the aqueous extract of the Dentaswiss Enamel Repair & Protect paste is confirmed by an increase in the surface tension of the solution with an increase in the paste content in the aqueous suspension. This indicates the anti-inflammatory effect of the studied therapeutic and prophylactic toothpasteДля изучения физико-химических свойств зубной пасты «Dentaswiss» Enamel Repair&Protect приготовлены её водные вытяжки различной концентрации. Установлена их высокая электропродность, котораяобусловлена присутствием сильного электролита – хлорида натрия, а также значительным количеством кальция 0,98-2,18±0,01ммоль/л, содержащегося в ионизированном состоянии. Именно этот ионизированный кальций участвует в процессах минерализации эмали при использовании данной зубной пасты.Высокая концентрация солей в водной вытяжке пасты «Dentaswiss» Enamel Repair&Protect, подтверждается увеличением поверхностного натяжения раствора с увеличением содержания пасты в водной суспензии. Это свидетельствует о противовоспалительном эффекте исследуемой лечебно- профилактической зубной паст

The risk of developing autonomic dysreflexia during urodynamic testing in patients after spinal cord injury

Introduction. Autonomic dysreflexia (AD) is a life-threatening dangerous condition in patients with spinal cord injury (SCI) above the T6 segment level. It is characterized by a sudden rise in systolic blood pressure more than 20 mmHg, and unpredictable reactions from the autonomic nervous system. An episode of autonomic dysreflexia can lead to several cardiovascular catastrophes – heart attack and/or acute cerebrovascular accident up to a lethal outcome. Currently, there is no diagnostic algorithm and no way to determine risk factors for the occurrence of autonomic dysreflexia.Objective. To search for the most informative diagnostic criteria for autonomic dysreflexia in patients with spinal cord injury.Materials and methods. The study included 40 patients with SCI above the T6 segment. Depending on the SCI degree, two groups were distinguished. Group 1 (n = 14) included patients with complete spinal cord injury, advising category A on the ASIA scale. Group 2 (n = 26) included patients with incomplete spinal cord injury, classified as ASIA-B, C, D. For a preliminary assessment of the risk factors for the development of AD, an ADFSCI questionnaire was used, then a urodynamic study was conducted with simultaneous registration of systolic / diastolic blood pressure (SBP / DBP), and heart rate, which confirmed or denied the presence of AD in patients.Results. According to the ADFSCI questionnaire, most patients showed a high degree of severity of autonomic disorders, suggesting the presence of AD. Subsequently, this assumption was confirmed by the results of a urodynamic testing with simultaneous monitoring of SBP / DBP and heart rate. When comparing the groups, statistically significant differences were found in the parameters of the ADFSCI questionnaire, as well as in the indicators of SBP / DBP (at the points of maximum detrusor pressure and when the cystometric capacity is reached).Conclusion. The obtained results allow us to draw conclusions about the high incidence of AD in patients with SCI above the T6 segment and the need for a preliminary assessment of the risks of developing this condition based on the ADFSCI questionnaire before conducting a urodynamic study. Considering the possible complications of AD, the urodynamic testing should be accompanied by continuous monitoring of the indicators of the cardiovascular system

Investigation of creatinine indicators during dialysis therapy

The aim of the study – to demonstrate clinical cases of increased creatinine in biochemical blood analysis against the background of renal insufficiency, to evaluate the effectiveness of renal replacement therapy.Цель исследования – демонстрация клинических случаев повышения креатинина в биохимическом анализе крови на фоне почечной недостаточности, оценка эффективности заместительной почечной терапии