"El futuro de las revistas científicas españolas: un esfuerzo científico, social e institucional", en Revista española de documentación científica, vol. 24, n. 3, 2001

Sección: ReseñasEn este artículo investigadores y editores de revistas científicas españolas (algunas del CSIC) denuncian la situación que viven éstas, ahogadas por la excesiva relevancia que se da a las que están registradas en el ISI (grupo en el que entran muy pocas revistas españolas).N

In-Flight Broadband Connectivity : Architectures and Business Models for High Capacity Air-to-Ground Communications

In-flight broadband connectivity (IFBC) is a significant open market for mobile network operators considering more than 3.3 billion passengers being served by airlines in2015. On-board broadband services are provided via air-to-ground(A2G) connectivity through direct A2G communications(DA2GC) and satellite A2G communications (SA2GC). Available on-board connectivity systems have significant limitations: high latency in SA2GC and low capacity in DA2GC. The customer expectancy is multi-Mbps connections in every seat which leads to capacity requirements of Gbps to the aircraft. Creation of high capacity IFBC requires a collaborative interaction between different industrial partners. For this reason, we investigate A2Garchitectures in terms of economic and technical perspectives, and propose business models by identifying new roles and positioning them in the A2G business ecosystem. In addition, we provide an extensive summary of the state-of-the-art and future improvements for A2G communications.QCR 20170814ICARO-E

Production of a cellular product consisting of monocytes stimulated with Sylatron® (Peginterferon alfa-2b) and Actimmune® (Interferon gamma-1b) for human use

Abstract Background Monocytes are myeloid cells that reside in the blood and bone marrow and respond to inflammation. At the site of inflammation, monocytes express cytokines and chemokines. Monocytes have been shown to be cytotoxic to tumor cells in the presence of pro-inflammatory cytokines such as Interferon Alpha, Interferon Gamma, and IL-6. We have previously shown that monocytes stimulated with both interferons (IFNs) results in synergistic killing of ovarian cancer cells. We translated these observations to an ongoing clinical trial using adoptive cell transfer of autologous monocytes stimulated ex vivo with IFNs and infused into the peritoneal cavity of patients with advanced, chemotherapy resistant, ovarian cancer. Here we describe the optimization of the monocyte elutriation protocol and a cryopreservation protocol of the monocytes isolated from peripheral blood. Methods Counter flow elutriation was performed on healthy donors or women with ovarian cancer. The monocyte-containing, RO-fraction was assessed for total monocyte number, purity, viability, and cytotoxicity with and without a cryopreservation step. All five fractions obtained from the elutriation procedure were also assessed by flow cytometry to measure the percent of immune cell subsets in each fraction. Results Both iterative monocyte isolation using counter flow elutriation or cryopreservation following counter flow elutriation can yield over 2 billion monocytes for each donor with high purity. We also show that the monocytes are stable, viable, and retain cytotoxic functions when cultured with IFNs. Conclusion Large scale isolation of monocytes from both healthy donors and patients with advanced, chemotherapy resistant ovarian cancer, can be achieved with high total number of monocytes. These monocytes can be cryopreserved and maintain viability and cytotoxic function. All of the elutriated cell fractions contain ample immune cells which could be used for other cell therapy-based applications