126 research outputs found
Yeast hexokinase reaction with adenosine 5′-O-triphosphate and adenosine 5′-O-(1-thio-triphosphate) monitored by liquid chromatography
- Publication venue
- Published by Elsevier B.V.
- Publication date
- 01/04/1974
- Field of study
Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases
- Author
- A Abbott
- A Abou-Raya
- A Aljandali
- A Ambesi-Impiombato
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- A Balcerczyk
- A Besarab
- A Brzezinski
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- The Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group
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- ZZ Chong
- Publication venue
- Publication date
- 09/08/2008
- Field of study
The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular "reactive oxygen species" (ROSs)
can exhibit a number of biological effects, they are not of themselves
excessively reactive and thus they are not especially damaging at physiological
concentrations. However, their reactions with poorly liganded iron species can
lead to the catalytic production of the very reactive and dangerous hydroxyl
radical, which is exceptionally damaging, and a major cause of chronic
inflammation. We review the considerable and wide-ranging evidence for the
involvement of this combination of (su)peroxide and poorly liganded iron in a
large number of physiological and indeed pathological processes and
inflammatory disorders, especially those involving the progressive degradation
of cellular and organismal performance. These diseases share a great many
similarities and thus might be considered to have a common cause (i.e.
iron-catalysed free radical and especially hydroxyl radical generation). The
studies reviewed include those focused on a series of cardiovascular, metabolic
and neurological diseases, where iron can be found at the sites of plaques and
lesions, as well as studies showing the significance of iron to aging and
longevity. The effective chelation of iron by natural or synthetic ligands is
thus of major physiological (and potentially therapeutic) importance. As
systems properties, we need to recognise that physiological observables have
multiple molecular causes, and studying them in isolation leads to inconsistent
patterns of apparent causality when it is the simultaneous combination of
multiple factors that is responsible. This explains, for instance, the
decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference
Fluorescent protein-tagged Vpr dissociates from HIV-1 core after viral fusion and rapidly enters the cell nucleus
- Author
- A Fassati
- A Okumura
- A Varin
- AC Saphire
- AE Hulme
- B Kim
- B Muller
- B Poon
- B Romani
- BM Dale
- BM Forshey
- C Aiken
- C Depienne
- CA Guenzel
- CF Pereira
- Chetan Sood
- Christopher Aiken
- D McDonald
- DA Eckstein
- DJ Wyma
- E Le Rouzic
- EA Cohen
- EA Cohen
- EM Campbell
- EM Campbell
- Fatima Nawaz
- G Jacquot
- Gregory B. Melikyan
- H de Rocquigny
- H Liu
- J Llopis
- J Shi
- Jiong Shi
- JP Belzile
- JV Fritz
- JW Balliet
- K Miyauchi
- K Miyauchi
- K Muthumani
- K Peng
- KI Joo
- L Selig
- LH Demirkhanyan
- LK Felzien
- M Cavrois
- M de la Vega
- M Hrimech
- M Lampe
- M Mashiba
- M Shimura
- MA Accola
- Mariana Marin
- MG Waldhuber
- MP Sherman
- MV Nermut
- N Arhel
- N Dross
- N Kondo
- N Laguette
- NK Heinzinger
- NK Jha
- P Gallay
- P Jauregui
- P Roux
- R Liu
- R Welker
- RC Burdick
- RC Netter
- RH Stauber
- RI Connor
- S de Silva
- S Hoshino
- S Jun
- S Narayan
- S Padilla-Parra
- S Padilla-Parra
- S Padilla-Parra
- S Popov
- S Zhang
- SP Singh
- Tanay M. Desai
- V Liska
- V Malikov
- VB Shah
- VN Kewalramani
- WC Goh
- X Wei
- X Wu
- XJ Yao
- Y Jenkins
- Y Jenkins
- Z Ambrose
- Z Lukic
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
A História da Alimentação: balizas historiográficas
- Author
- ABDALA Mônica Chaves
- ABEL Wilhelm
- ABEL Wilhelm
- ADAMS C. J.
- ADAMS D.
- ADAMS James S
- ALBERT Jean-Pierre
- AlDELLS Bruce
- ALGRANTI Leila Mezan
- AMARAL LuÃs
- AMOURElTI M. c
- ANDERSON Eugene N
- ANDERSON Eugene N.
- ANDROUET P.
- ANDRÉ J.
- APFELBAUM M
- APPADURAI Arjun
- APPADURAI Arjun
- APPLEBY A
- ARENS W
- ARNABOLDI J
- ARNOLD David
- ARNOTT Margaret
- ARON J.-P.
- ARON J.-P.
- ARON J.-P.
- ARON J.-P.
- ARON Jean-Paul
- ASHLEY Sir William
- ASHTON John
- AURELL Martin
- AYKROYD WR
- AYMARD M.
- AYMARD Maurice
- AYMARD Maurice
- AZEVEDO Esterzilda de
- BACCI Livi
- BALDVS Herbert
- BALL Daniela
- BARKER T. c.
- BARLOSIUS Eva
- BARTHES Roland
- BASINI G.L
- BATAILLE-BENGUlGUI M.C
- BAULANT M.
- BAVER Beatrice
- BEAUREGARD M.
- BEJARANO Jorge Alfonso
- BELASCO Warren
- BELL David
- BENASSAR B. B
- BENNET M. K.
- BENTLEY Amy
- BERGIER J.-E
- BERTHIAUME G
- BERTIN Jacques
- BERTUCCI Liane
- BIRKET-SMITH K.
- BLANC Nicole
- BLOND G
- BlRABEN J.N.
- BOGUCKI Peter
- BOIS D.
- BOLENS Lucie
- BONASSIE Pierre
- BONIN Ana Maria A
- BONNET J.-C
- BOSERUP Ester
- BOURDEAU L
- BOURGAUX A
- BRAA Dean M
- BRADY lvan
- BRANDÃO Darwin
- BRANS JO
- BRAUDEL Fernand
- BRAUDEL Fernand
- BRAUDEL Fernand
- BRENNAN T
- BRESClANI Edda
- BRIFFAULT E
- BRIGNOLI Héctor Pérez
- BRILLAT-SAVARlN J.A
- BROCHADO José Proenza
- BROTHWELL Don
- BROWN L.K
- BRUEGEL M
- BRUN Thierry A
- BRYANT Carol
- BURGUlERE André
- BURNETT J
- BUTEL P
- BYNUM Caroline W
- CALVO I.
- CAMARGO Rogério de
- CAMPORESI Piero
- CAMPORESI Piero
- CANNABRAVA Alice
- CAPLAN Pat
- CARNEIRO Henrique
- CARNEY George O
- CASCUDO LuÃs da Câmara
- CASCUDO LuÃs da Câmara
- CASCUDO LuÃs da Câmara
- CASCUDO LuÃs da. Câmara
- CASTRO Josué de
- CASTRO Josué de
- CASTRO Josué de
- CASTRO Josué de
- CASTRO Josué de
- CASTRO Josué de
- CASTRO Josué de
- CASTRO Josué de
- CASTRO Josué de
- CAUVIN J
- CEPEDE M.
- CERECEDA Dantin
- CHALONER William Henry
- CHALOUB Sidney
- CHANG Kwang-chih
- CHARBONNIER P
- CHARLES Nicky
- CHARLES Nicky
- CHARSLEY Simon R.
- CHAUDIEU G.
- CHAUNU Pierre
- CHEKE Valerie
- CHONCHOL Jacques
- CHRISPEELS M.J.
- CHRISTO Maria Stella Ubânio de
- CLERGEAUD e
- CLUTTON-BROCK Juliet
- COE Sophie D
- COE Sophie D.
- COHEN M. N
- COHEN M.N
- CONNEL K. H.
- COOK lan
- COOPER Charles
- CORLEY T. E. B.
- COSTA Dante
- COUNlHAN Carole
- COUNlHAN Carole
- COURIE P.
- CRANE E
- CRAPLET e
- CURTIN Deane W
- DALBY Andrew
- DALBY Andrew
- DANDO WA
- DAUPHIN e
- DAVID Louis
- DE BENEDETTIS Renata
- DE LAET Sigfried Jan
- DE NIRO M
- DEERR Noel
- DEL PRIORE Mary
- DENTON Derek
- DESPORTES E
- DETIENNE Mareei
- DION R
- DISNEY A.R
- DODD George
- DORVEAUX P
- DOUGLAS Mary
- DOUGLAS Mary
- DOUGLAS Mary
- DOUGLAS Mary
- DOUGLAS Mary
- DOUGLAS Mary
- DOUGLAS Mary
- DRIVER Christopher
- DRUMOND J. C
- DUBISCH Jill
- DUPIN H
- DÉSERT G
- ECKSTEIN Fritz
- EIRAS ROEL A
- ELIAS Norbert
- ELLEN Roy
- ELLIS Ellen D
- ELLIS Myriam
- ELY Roland T
- ESCUDERO Pedro
- ESPINOSA Alfredo Ramos
- FACCIOLI Emilio
- FALK P.
- FARB P
- FARELL M.H
- FARIA Oswaldo Lamartine de
- FEBVRE I.
- FEELEY-HARNIK Gillian
- FENTON A
- FERLINI Vera Lúcia do Amaral
- FERRONHA António LuÃsA. Ferronha
- FERRÃO José E. Mendes
- FIDDES Nick
- FIELD R
- FIELDHOUSE Paul
- FIGUEIREDO Luciano R. de Almeida
- FINE Ben
- FINE Gary AIan
- FINKELSTEIN Joanne
- FISCHLER Claude
- FISCHLER Claude
- FISCHLER Claude
- FISCHLER Claude
- FISCHLER Claude
- FISCHLER Claude
- FITCHEN J.M
- FITZGERALD T.K
- FLANDRIN Jean-Louis
- FLANDRIN Jean-Louis
- FLANDRIN Jean-Louis
- FLANDRIN Jean-Louis
- FLANDRIN Jean-Louis
- FLANDRIN Jean-Louis
- FLANDRIN Jean-Louis
- FLANDRIN Jean-Louis
- FLANDRIN Jean-Louis
- FLANDRIN Jean-Louis
- FORREST D. M.
- FORSTER E
- FORSTER Robert
- FOSTER Nelson
- FOURIER Charles
- FOURNIER Dominique
- FRANKLIN T. B
- FREEDMAN R.L
- FREEDMAN R.L
- FREYRE Gilberto
- FREYRE Gilberto
- FRIEIRO Eduardo
- FRIJHOFF W
- GALAVARIS George
- GALVÃO Eduardo
- GAMA Ruy
- GANDHI M
- GARCIA Rosa
- GARINE Igor de
- GARINE lgor de
- GARNSEY P.D.A
- GARRIER G.
- GEREMEK Bronislao
- GIBLIN James Cross
- GIOBELLINA-BRUMANA F.
- GIRARD A
- GOFFON Leslie
- GOLDEN Lilly
- GOODY Jack
- GOTISCHALK A
- GOWERS E
- GRIGNON Claude
- GRIGNON Claude
- GRIGNON Claude
- GRIMM Veronika
- GRONOW Jukka
- GROTANELLI Cristiano
- GROVER Kathryn
- GUEVARA Arturo
- HALPERN PEREIRA M.
- HANN C. M.
- HARDWICH Nikita
- HARRIS Marvin
- HARRlS David R
- HARRlS David R
- HARRlS Marvin
- HARRlS Marvin
- HARRlSON Brian
- HARRlSON Brian
- HAUDRICOURT A.-G
- HELDKE Lisa M
- Henrique Carneiro
- HERPIN N.
- HEYNE Moriz
- HINZ Evelyn
- HOCQUET Jean-Claude
- HOLANDA Sérgio Buarque de
- HOUAISS Antonio
- HUGILL Antony
- HÉMARDINQUER J.J.
- HÉMARDINQUER J.J.
- HÉMARDINQUER J.J.
- HÉMARDINQUER J.J.
- IOSSIFIEDES
- JACOB H.-E.
- JACOB H.-E.
- JEROME N.W
- JOHNSSON M.
- JOHNSTON EE.
- JOHNSTON James P.
- JULIÃO Francisco
- KAPLAN Steve Laurence
- KAPLAN Steve Laurence
- KATES Robert
- KHARE RS.
- KING FrankA
- KNAGGS Henry V.
- KRAUT A.
- KROPOTKIN Piotr
- KUPER Jessica
- LaFOLLETE Robert
- LE ROY LADURIE Emmanuel
- LEACH E
- LEACH Helen
- LEAF Murray J
- LECLANT J
- LEGRAND D'AUSSY Pierre J.B.
- LEIDNER Robin
- LEMERY Louis
- LEMOS Carlos Alberto Cerqueira
- LENTZ Carola
- LEVENSTEIN Harvey A
- LEVENSTEIN Harvey A
- LEVIN
- LICHTENFELT AIfred
- LIFSCHITZ Javier
- LIFSCHITZ Javier
- LIMA Tania Andrade
- LINHARES Maria Yeda
- LINHARES Maria Yedda
- LINHARES Maria Yedda
- LINHARES Maria Yedda
- LINHARES TemÃstocles
- LIPPMAN Edmund Oskar
- LISANTI Fo LuÃs
- LISSARRAGUE François
- LISSARRAGUE François
- LIVI-BACCI M
- LLAURIOUX Bruno
- LODY Raul
- LOMBARDO Mario
- LONGO Oddone
- LOPES Renato Souza
- LOVEDAY M
- LOWE Heinz-Dietrich
- LUPTON Deborah
- LUPTON Deborah
- LÉVI-STRAUSS CIaude
- LÉVI-STRAUSS Claude
- LÉVI-STRAUSS Claude
- LÉVI-STRAUSS Claude
- LÉVI-STRAUSS Claude
- MACHEREL Claude
- MACLEAN Virginia
- MADONES G
- Mafalda ZEMELLA
- MAGALHÃES BasÃlio de
- MAGALHÃES Eduardo Fernandes de
- MALINOWSKI B
- MANDERSON Leonore
- MARCONI Marina de Andrade
- MARENCO C
- MARS Gerald
- MATOSSIAN Mary Kilbourne
- MAURIZIO Adam
- MAURO Frédéric
- MAUÉS Maria Angélica Motta
- MAUÉS Raimundo H
- MAYOLO R
- MAZZINI Innocenzo
- McCANCE Robert A
- McCOLLUM Elmer Verner
- McGEE Harold
- McGOVERN Patrick
- McINTOSH Laine N
- McKEOWN Thomas
- McMILLAN Della E
- MELLO Antônio da Silva
- MELLO Evaldo Cabral de
- MELLO Jorge Saldanha Bandeira de
- MELLO José Antonio Gonçalves de
- MELO Antonio da Silva
- MELO Antonio da Silva
- MENDEL G
- MENNELL Stephen
- MENNELL Stephen
- MENNELL Stephen
- MENNELL Stephen
- MEPHAM Bem
- MESSER Ellen
- MESSÉGUÉ Maurice
- MICHEL Henri
- MIGLIARI M.L
- MILLMAN Sara
- MILLMAN Sara
- MINTZ Sidney W
- MINTZ Sidney W
- MINTZ SidneyW
- MOLLAT M
- MONCKTON H.A
- MONTANARI Massimo
- MONTANARI Massimo
- MONTANARI Massimo
- MONTANARl Massimo
- MONTEIRO Agostinho
- MONTEIRO Mário Ypiranga
- MOREIRA Nicolau joaquim
- MORINEAU M
- MOSKOWITZ H
- MOULIN L
- MOULIN L
- MOUNT J.L
- MOURA Hugo
- MOWAT Linda
- MUCHNIK J
- MURCOTI Anne
- MURCOTI Anne
- MURCOTI Anne
- MURCOTT Anne
- MURCOTT Anne
- MURRAY Oswyn
- MURRAY Oswyn
- NAHOUM-GRAPPE Véronique
- NALLO E. Di
- NELSON M
- NEVEUX H
- NEWMAN Lucile E
- NICOLAlDES Stylianos
- NIELSEN Inge
- NOURISSON Didier
- NOURRISON Didier
- NOVAlS Fernando
- OHNUKI-TIERNEY Emiko
- ORBACH Susie
- ORNELLAS Lieselotte Hoeschl
- ORSTER Elborg
- ORTENCIO Bariani
- ORTIZ Femando
- ORTIZ Femando
- PAIMER Amold
- PAIMER Catherine
- PANCOAST H
- PANTEL Pauline Schmitt
- PARAISO Aviva
- PATRONE A. M
- PENDERGAST Mark
- PEREIRA J
- PERI I
- PESEZ Jean-Marie
- PESSANHA Nely M
- PIERSON Donald
- PIERSON Lionel James
- PILLSBURY Richard
- PIPERNO DoIores R
- PITIE Jean-Robert
- PIUZ A.-M
- POKHLEBKIN William
- POO Mu-chou
- POTTIER Johan
- POULOT Dominique
- PRAKASH O
- PRENTICE Parmalle
- PRICE T. DougIas
- PRICE Weston
- PULLAR P
- PYNSON P
- QUIGLEY D.T
- RAINWATER Dorothy
- RAMINELLI Ronald
- REDDING Richard W
- REED William
- REEDS J.A
- RENFREW Colin
- RENFREW J
- RENNER H. D
- REVEL Jacques
- REVEL Jean François
- REVEL Jean François
- RIBEIRO Berta G
- RIBEIRO Joaquim
- RICHARDS Audrey 1
- RICHARDS Audrey 1
- RITCHIE Carson I.A
- RIVERS J
- ROBSON John R.K
- ROCHE Daniel
- RODINSON M
- Rom Bodris
- ROOT Waverly
- ROSALDO M.Z
- ROSEBERRY William
- ROSS E
- ROTBERG R.I
- ROWLEY Aothony
- ROYER c
- ROZIN Elizabeth
- SABBAN Françoise
- SABBAN Françoise
- SAHLINS Marshall
- SAHLINS Marshall
- SAILLENPEST J
- SALAMAN Redcliffe N
- SALDANHA Nelson
- SAMPAIO A.J
- SANTOS Carlos Roberto Antunes dos
- SCARANO Julita
- SCARANO Julita
- SCARPI Paolo
- SCHIVELBUSCH Wolfgang
- SCHWARTZ Hillel
- SCHWARTZ Stuart B
- SCRIMSHAW Nevin S
- SEEGER Anthony
- SEN Amartya K
- SENTIERI M
- SERED Susan Starr
- SHAND P.M
- SHAW T
- SHELTON Allen
- SHELTON Walter James
- SHEPPARD Ronald
- SILVA Francisco Carlos Teixeira da
- SILVA Francisco Carlos Teixeira da
- SILVA G.J. da Rosa e
- SILVA Maria Beatriz Nizza da
- SILVA Maria Beatriz Nizza da
- SIMMEL Georg
- SIMON André
- SIMOONS Fredericky
- SLATER WJ
- SLOCUM S
- SMART Barry
- SMITH Bruce D
- SMITH R.E.E
- SOLER Jean
- SOLER Jean
- SORRO M
- SOUTO MAIOR M
- SOUTO MAIOR M
- SOUTO MAIOR M
- SOUTO MAIOR Mário
- SPENCER Colin
- STEAD J
- STERN Radu
- STEWART A
- STOIANOVITCH T
- STOIANOVITCH T
- STOUFF Louis
- STRONG 1.A.G
- STRUNG Norman
- STUYVENBERG J. H. Van
- SUPER John C
- SUTTON David C
- SUTTON David C
- SUYEUX J
- TANNAHILL Reay
- TARRANT J
- TAUNAY Affonso d'E
- TCHERNIA A
- TELEKI G
- TELFER Elizabeth
- TEMPLE F.-J
- TEUTEBERG H.-J
- TEUTEBERG Hans-Jürgen
- TEUTEBERG Hans-Jürgen
- THIEL Barbara
- TOMUSON A
- TOUSSAINT-SAMAT Maguelonne
- TOUTAIN J.-C
- TRAGER James
- TUZIN D
- TWIGG J
- TWINING Stephen H
- UKERS WH
- Ulpiano T.Bezerra de Meneses
- UNWIN T
- V1SSER Margaret
- VAILLANT G.E
- VALENTINE Gill
- VALERI René
- VAN BATH B.H
- VAN DEN BERGHE Pierre
- VANDENBROEKE Christiaan
- VANDENBROEKE Christiaan
- VARELLA J.S. das Chagas
- VEDEL J
- VELHO Octávio Guilherme
- VELOSO Carlos
- VELOSO Cleto Seabra
- VERDIER Y
- VIALLES Noelle
- VINCENT B
- VOLPATO G
- WALDORF Cornelius
- WATSON B
- WATSON James
- WATT James
- WAUGH A
- WEISMANTEL Mary
- WIDDOWSON J
- WIEGELMANN Günter
- WIESSNER Polly
- WILDT Michael
- WILKINS Jobo Harvey
- WILLIAMS Robert G
- WILSON C.S
- WILSON Constance Anne
- WOOD R
- WOORTMAN Klaas
- WOORTMANN Klaas
- WYNNE-TYSON J
- YOUNG L
- YUDKIN John
- YVOREL Jean-Jacques
- ZEUNER E E
- ZILHR W
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- 01/01/1997
- Field of study
Os M. pretenderam traçar um quadro da História da Alimentação, não como um novo ramo epistemológico da disciplina, mas como um campo em desenvolvimento de práticas e atividades especializadas, incluindo pesquisa, formação, publicações, associações, encontros acadêmicos, etc. Um breve relato das condições em que tal campo se assentou faz-se preceder de um panorama dos estudos de alimentação e temas correia tos, em geral, segundo cinco abardagens Ia biológica, a econômica, a social, a cultural e a filosófica!, assim como da identificação das contribuições mais relevantes da Antropologia, Arqueologia, Sociologia e Geografia. A fim de comentar a multiforme e volumosa bibliografia histórica, foi ela organizada segundo critérios morfológicos. A seguir, alguns tópicos importantes mereceram tratamento à parte: a fome, o alimento e o domÃnio religioso, as descobertas européias e a difusão mundial de alimentos, gosto e gastronomia. O artigo se encerra com um rápido balanço crÃtico da historiografia brasileira sobre o tema
Action of restriction endonucleases on phosphorothioate DNA
- Author
- Publication venue
- 'Portland Press Ltd.'
- Publication date
- Field of study
Ein Beitrag zur experimentellen Parasitologie der Insekten
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
RNAi impacts the world of antisense
- Author
- Publication venue
- Publication date
- 01/01/2003
- Field of study
5′-Deoxy-5′-thioribonucleoside-5′-triphosphates
- Publication venue
- Elsevier Science
- Publication date
- 10/02/1997
- Field of study
5′-Deoxy-5′-thiouridine- and 5′-deoxy-5′-thioadenosine-5′-triphosphate 6 and 7were chemically synthesised by two methods. Their incorporation into RNA to produce a 5′-S-bridging phosphorothioate internucleotide linkages, using T7 RNA polymerase, was investigated.
Reaction of P1-(S)-thiotriphosphate with 5′-iodo-5′-deoxynucleoside leads to 5′-deoxy-5′-thioribonucleoside-5′-triphosphates. Their incorporation into RNA to produce a 5′-S-bridging phosphorothioate internucleotide linkage, using T7 RNA polymerase, was investigated
Antisense oligonucleotides as potential drugs
- Publication venue
- Wiley-VCH
- Publication date
- 01/01/2004
- Field of study
Incomplete primer extension during in vitro
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/1989
- Field of study
- …