4,261 research outputs found
Making a case for introspection
Defending first-person introspective access to own mental states, we argue against Carruthers' claim of mindreading being prior to meta-cognition and for a fundamental difference between how we understand our own and others' mental states. We conclude that a model based on one mechanism but involving two different kinds of access for self and other is sufficient and more consistent with the evidence
Development during adolescence of the neural processing of social emotion
In this fMRI study, we investigated the development between adolescence and adulthood of the neural processing of social emotions. Unlike basic emotions (such as disgust and fear), social emotions (such as guilt and embarrassment) require the representation of another's mental states. Nineteen adolescents (10–18 years) and 10 adults (22–32 years) were scanned while thinking about scenarios featuring either social or basic emotions. In both age groups, the anterior rostral medial prefrontal cortex (MPFC) was activated during social versus basic emotion. However, adolescents activated a lateral part of the MPFC for social versus basic emotions, whereas adults did not. Relative to adolescents, adults showed higher activity in the left temporal pole for social versus basic emotions. These results show that, although the MPFC is activated during social emotion in both adults and adolescents, adolescents recruit anterior (MPFC) regions more than do adults, and adults recruit posterior (temporal) regions more than do adolescents
Search for evidence of trend slow-down in the long-term TOMS/SBUV total ozone data record: the importance of instrument drift uncertainty and fingerprint detection
International audienceWe have developed a merged ozone data (MOD) data set for the period October 1978 through October 2005 combining total ozone measurements (version 8 retrieval) from the TOMS (Nimbus 7, Meteor 3, and Earth Probe) and SBUV/SBUV2 (Nimbus 7, NOAA 9/11/16) series of satellite instruments. We use MOD to search for evidence of ozone recovery in response to the observed leveling off of chlorine compounds in the stratosphere. A crucial step in any time series analysis is the evaluation of uncertainties. In addition to the standard statistical time-series uncertainties, we evaluate the possible instrumental drift uncertainty for the MOD data set. We combine these two sources of uncertainty and apply them to a cumulative sum of residuals (CUSUM) analysis for trend slow-down. For the quasi-global mean between 60° S and 60° N, the apparent slow-down in trend is found to be clearly significant if instrument uncertainties are ignored. When instrument uncertainties are added, the slow-down becomes marginally significant at the 2? level. For the mid-latitudes of the northern hemisphere (30° to 60° N) the trend slow-down is significant. For the mid-latitudes of the southern hemisphere (30° to 60° S) it is not significant. The fingerprint of ozone recovery expected from model calculations suggests both northern and southern mid-latitude total ozone levels should recover together. Our result fails this fingerprint test and is therefore not a demonstration of the response of total ozone to the leveling off of chlorine
Mindblind eyes: an absence of spontaneous theory of mind in Asperger syndrome
Adults with Asperger syndrome can understand mental states such as desires and beliefs (mentalizing) when explicitly prompted to do so, despite having impairments in social communication. We directly tested the hypothesis that such individuals nevertheless fail to mentalize spontaneously. To this end, we used an eye-tracking task that has revealed the spontaneous ability to mentalize in typically developing infants. We showed that, like infants, neurotypical adults’ (n = 17 participants) eye movements anticipated an actor’s behavior on the basis of her false belief. This was not the case for individuals with Asperger syndrome (n = 19). Thus, these individuals do not attribute mental states spontaneously, but they may be able to do so in explicit tasks through compensatory learning
Functional specialization within rostral prefrontal cortex (Area 10): a meta-analysis
One of the least well understood regions of the human brain is rostral prefrontal cortex, approximating Brodmann's area 10. Here, we investigate the possibility that there are functional subdivisions within this region by conducting a meta-analysis of 104 functional neuroimaging studies (using positron emission tomography/functional magnetic resonance imaging). Studies involving working memory and episodic memory retrieval were disproportionately associated with lateral activations, whereas studies involving mentalizing (i.e., attending to one's own emotions and mental states or those of other agents) were disproportionately associated with medial activations. Functional variation was also observed along a rostral-caudal axis, with studies involving mentalizing yielding relatively caudal activations and studies involving multiple-task coordination yielding relatively rostral activations. A classification algorithm was trained to predict the task, given the coordinates of each activation peak. Performance was well above chance levels (74% for the three most common tasks; 45% across all eight tasks investigated) and generalized to data not included in the training set. These results point to considerable functional segregation within rostral prefrontal cortex
Gentle Masking of Low-Complexity Sequences Improves Homology Search
Detection of sequences that are homologous, i.e. descended from a common ancestor, is a fundamental task in computational biology. This task is confounded by low-complexity tracts (such as atatatatatat), which arise frequently and independently, causing strong similarities that are not homologies. There has been much research on identifying low-complexity tracts, but little research on how to treat them during homology search. We propose to find homologies by aligning sequences with “gentle” masking of low-complexity tracts. Gentle masking means that the match score involving a masked letter is , where is the unmasked score. Gentle masking slightly but noticeably improves the sensitivity of homology search (compared to “harsh” masking), without harming specificity. We show examples in three useful homology search problems: detection of NUMTs (nuclear copies of mitochondrial DNA), recruitment of metagenomic DNA reads to reference genomes, and pseudogene detection. Gentle masking is currently the best way to treat low-complexity tracts during homology search
Forty years on: Uta Frith's contribution to research on autism and dyslexia, 1966–2006
Uta Frith has made a major contribution to our understanding of developmental disorders, especially autism and dyslexia. She has studied the cognitive and neurobiological bases of both disorders and demonstrated distinctive impairments in social cognition and central coherence in autism, and in phonological processing in dyslexia. In this enterprise she has encouraged psychologists to work in a theoretical framework that distinguishes between observed behaviour and the underlying cognitive and neurobiological processes that mediate that behaviour
Rheology of protein-stabilised emulsion gels envisioned as composite networks. 2 - Framework for the study of emulsion gels
The aggregation of protein-stabilised emulsions leads to the formation of
emulsion gels. These soft solids are classically envisioned as droplet-filled
matrices. Here however, it is assumed that protein-coated sub-micron droplets
contribute to the network formation in a similar way to proteins. Emulsion gels
are thus envisioned as composite networks made of proteins and droplets.
Emulsion gels with a wide range of composition are prepared and their
viscoelasticity and frequency dependence are measured. Their rheological
behaviours are then analysed and compared with the properties of pure gels
presented in the first part of this study. The rheological behaviour of
emulsion gels is shown to depend mostly on the total volume fraction, while the
composition of the gel indicates its level of similarity with either pure
droplet gels or pure protein gels. These results converge to form an emerging
picture of protein-stabilised emulsion gel as intermediate between droplet and
protein gels. This justifies a posteriori the hypothesis of composite networks,
and opens the road for the formulation of emulsion gels with fine-tuned
rheology.Comment: 22 pages, 5 figure
Knowing me, knowing you: Spontaneous use of mentalistic language for self and other in autism
Recent studies on mentalizing have shown that autistic individuals who pass explicit mentalizing tasks may still have difficulties with implicit mentalizing tasks. This study explores implicit mentalizing by examining spontaneous speech that is likely to contain mentalistic expressions. The spontaneous production of meta-statements provides a clear measure for implicit mentalizing that is unlikely to be learned through experience. We examined the self- and other-descriptions of highly verbally able autistic and non-autistic adults in terms of their spontaneous use of mentalistic language and meta-representational utterances through quantitative and qualitative analysis. We devised a hierarchical coding system that allowed us to study the types of statements produced in comparable conditions for the self and for a familiar other. The descriptions of autistic participants revealed less mentalistic content relating to psychological traits and meta-statements. References to physical traits were similar between groups. Within each group, participants produced a similar pattern of types of mental utterance across ‘self’ and ‘other’ conditions. This suggests that autistic individuals show a unique pattern of mental-state-representation for both self and other. Meta-statements add a degree of complexity to self- and other-descriptions and to the understanding of mental states; their reduction in autism provides evidence for implicit mentalizing difficulties
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