Otosclerosis—an inflammatory disease of the otic capsule of viral aetiology?

Fragments of otospongiotic and otosclerotic footplates were investigated by immunohistochemical methods. Antibodies IgG, IgA, IgM were found to be found to the vascular connective tissue of the resorption lacunae, IgG also to osteocytes. The application of antibodies against mumps, measles and rubella antigens showed the expression of the relevant viral antigens in the large cells of the resorption lacunae, in the vascular connective tissue, and in osteocytes, osteoclasts and chondrocytes, present in or around the otospongiotic areas. In the sclerotic stage only the perivascular connective tissue and chondrocytes have expressed viral antigens whereas IgG was restricted to the osteocytes of the sclerotic focus and to the residual perivascular tissue. Two footplates with postinflammatory sclerosis serving as controls revelaed only IgG in some chondrocytes. Healthy footplates showed neither a deposition of antibodies nor any expression of viral antigens. These results favour a viral aetiology of otosclerosis as an inflammatory vasclar reaction of the otic capsule initiated or caused by the viruses of measles, rubella and mump

Local Strategy Improvement for Parity Game Solving

The problem of solving a parity game is at the core of many problems in model checking, satisfiability checking and program synthesis. Some of the best algorithms for solving parity game are strategy improvement algorithms. These are global in nature since they require the entire parity game to be present at the beginning. This is a distinct disadvantage because in many applications one only needs to know which winning region a particular node belongs to, and a witnessing winning strategy may cover only a fractional part of the entire game graph. We present a local strategy improvement algorithm which explores the game graph on-the-fly whilst performing the improvement steps. We also compare it empirically with existing global strategy improvement algorithms and the currently only other local algorithm for solving parity games. It turns out that local strategy improvement can outperform these others by several orders of magnitude

An Exponential Lower Bound for the Latest Deterministic Strategy Iteration Algorithms

This paper presents a new exponential lower bound for the two most popular deterministic variants of the strategy improvement algorithms for solving parity, mean payoff, discounted payoff and simple stochastic games. The first variant improves every node in each step maximizing the current valuation locally, whereas the second variant computes the globally optimal improvement in each step. We outline families of games on which both variants require exponentially many strategy iterations

Durability of Ag-TiO(2) Photocatalysts Assessed for the Degradation of Dichloroacetic Acid

The stability of Ag-TiO(2) photocatalysts was examined for the photocatalytic degradation of dichloroacetic acid (DCA) as a function of the recycling times. The photocatalytic activity was investigated by measuring the rate of H(+) ions released during the photodegradation of DCA and confirmed by measuring the total organic carbon removal. The photodegradation reactions were studied at pH 3 and pH 10 for a series of Ag-TiO(2) photocatalysts as different with Ag loadings. All the Ag-TiO(2) and bare TiO(2) photocatalysts showed a decrease in photocatalytic activity on recycling for the DCA photodegradation reaction. The decrease in activity can be attributed to poisoning of active sites by Cl(-) anions formed during the photocatalytic DCA degradation. The photocatalytic activity was, however, easily recovered by a simple washing technique. The reversibility of the poisoning is taken as evidence to support the idea that the recycling of Ag-P25 TiO(2) photocatalysts does not have a permanent negative effect on their photocatalytic performance for the degradation of DCA. The choice of the preparation procedure for the Ag-TiO2 photocatalysts is shown to be of significant importance for the observed changes in the photocatalytic activity of the Ag-TiO2 particles. Copyright (C) 2008 Victor M. Menendez-Flores et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Deutscher Akademischer Austausch Dienst (DAAD)Alexander-von-Humboldt-Stiftun

Symmetric Strategy Improvement

Symmetry is inherent in the definition of most of the two-player zero-sum games, including parity, mean-payoff, and discounted-payoff games. It is therefore quite surprising that no symmetric analysis techniques for these games exist. We develop a novel symmetric strategy improvement algorithm where, in each iteration, the strategies of both players are improved simultaneously. We show that symmetric strategy improvement defies Friedmann's traps, which shook the belief in the potential of classic strategy improvement to be polynomial

Geometric structure of the generic static traversable wormhole throat

Traversable wormholes have traditionally been viewed as intrinsically topological entities in some multiply connected spacetime. Here, we show that topology is too limited a tool to accurately characterize a generic traversable wormhole: in general one needs geometric information to detect the presence of a wormhole, or more precisely to locate the wormhole throat. For an arbitrary static spacetime we shall define the wormhole throat in terms of a 2-dimensional constant-time hypersurface of minimal area. (Zero trace for the extrinsic curvature plus a "flare-out" condition.) This enables us to severely constrain the geometry of spacetime at the wormhole throat and to derive generalized theorems regarding violations of the energy conditions-theorems that do not involve geodesic averaging but nevertheless apply to situations much more general than the spherically symmetric Morris-Thorne traversable wormhole. [For example: the null energy condition (NEC), when suitably weighted and integrated over the wormhole throat, must be violated.] The major technical limitation of the current approach is that we work in a static spacetime-this is already a quite rich and complicated system.Comment: 25 pages; plain LaTeX; uses epsf.sty (four encapsulated postscript figures

Cauchy Horizons, Thermodynamics and Closed Time-like Curves in Planar Supersymmetric Space-times

We study geodesically complete, singularity free space-times induced by supersymmetric planar domain walls interpolating between Minkowski and anti-de Sitter ($AdS_4$) vacua. A geodesically complete space-time without closed time-like curves includes an infinite number of semi-infinite Minkowski space-times, separated from each other by a region of $AdS_4$ space-time. These space-times are closely related to the extreme Reissner Nordstr\" om (RN) black hole, exhibiting Cauchy horizons with zero Hawking temperature, but in contrast to the RN black hole there is no entropy. Another geodesically complete extension with closed time-like curves involves space-times connecting a finite number of semi-infinite Minkowski space-times.Comment: 11 pages, 1 figure appended, phyzz