PROGRAMMING Intergenerational Exercise Addresses the Public Health Issue of Obesity

ABSTRACT. Health practitioners are increasingly concerned about the rise in obesity and decrease in physical activity in society. This article reports on an intergenerational exercise program involving participants from Jewish Community Housing for the Elderly and four preschool classes in Newton, Massachusetts. The program attempts to address those health issues using an intergenerational approach. Children between ages 3 and 5, and older adults come together weekly during the course of a school year for pre-literacy play, intergenerational stories that raise awareness of aging issues and nutritional snacks. An exercise class is added to this program monthly. The exercise component reflects the physical needs of both groups. The classes enable older adults to recognize their important role as models for lifelong exercise, while simultaneously addressing their own health habits. Children see olde

Connected Rhythm: A Scoping Review of Therapeutic Drumming as an Intervention for Autistic Individuals

Background: Autism Spectrum Disorder (ASD) is a neurologically-based developmental disorder representing a subdomain of neurodivergence. Occupational therapy intervention for ASD typically incorporates sensory modalities, addressing a multitude of challenges, including mental health outcomes. This scoping review analyzes available evidence of the sensory-based intervention of therapeutic drumming (TD) to improve mental health in autistic clients. Method: Following the Johanna Briggs methodological framework, Proquest, Ebsco, Scopus and OTseeker databases were searched with the key and related words of “autism,” “therapeutic drumming,” and “mental health,” yielding 448 articles. After removal of duplicates and application of inclusion criteria, seventeen articles were included in the final analysis. Results: Analysis revealed strong consistency in delivery and implementation of TD intervention. Instrumentation of outcome measures, in contrast, was not well-synchronized; therefore, efficacy of the intervention was difficult to assess. Conclusion: Limitations included a general lack of research, limited research of TD with autistic people in occupational therapy literature, and a dearth of strongly instrumented research. This review revealed valuable contributions of TD interventions as a neurodiversity-affirming practice to support mental health and inform future studies of implementation of TD for people with ASD across the lifespan within the scope of occupational therapy

MFGE8 does not influence chorio-retinal homeostasis or choroidal neovascularization in vivo

Purpose: Milk fat globule-epidermal growth factor-factor VIII (MFGE8) is necessary for diurnal outer segment phagocytosis and promotes VEGF-dependent neovascularization. The prevalence of two single nucleotide polymorphisms (SNP) in MFGE8 was studied in two exsudative or “wet” Age-related Macular Degeneration (AMD) groups and two corresponding control groups. We studied the effect of MFGE8 deficiency on retinal homeostasis with age and on choroidal neovascularization (CNV) in mice. Methods: The distribution of the SNP (rs4945 and rs1878326) of MFGE8 was analyzed in two groups of patients with “wet” AMD and their age-matched controls from Germany and France. MFGE8-expressing cells were identified in Mfge8+/− mice expressing ß-galactosidase. Aged Mfge8+/− and Mfge8−/− mice were studied by funduscopy, histology, electron microscopy, scanning electron microscopy of vascular corrosion casts of the choroid, and after laser-induced CNV. Results: rs1878326 was associated with AMD in the French and German group. The Mfge8 promoter is highly active in photoreceptors but not in retinal pigment epithelium cells. Mfge8−/− mice did not differ from controls in terms of fundus appearance, photoreceptor cell layers, choroidal architecture or laser-induced CNV. In contrast, the Bruch's membrane (BM) was slightly but significantly thicker in Mfge8−/− mice as compared to controls. Conclusions: Despite a reproducible minor increase of rs1878326 in AMD patients and a very modest increase in BM in Mfge8−/− mice, our data suggests that MFGE8 dysfunction does not play a critical role in the pathogenesis of AMD

Common Genetic Polymorphisms Influence Blood Biomarker Measurements in COPD

Implementing precision medicine for complex diseases such as chronic obstructive lung disease (COPD) will require extensive use of biomarkers and an in-depth understanding of how genetic, epigenetic, and environmental variations contribute to phenotypic diversity and disease progression. A meta-analysis from two large cohorts of current and former smokers with and without COPD [SPIROMICS (N = 750); COPDGene (N = 590)] was used to identify single nucleotide polymorphisms (SNPs) associated with measurement of 88 blood proteins (protein quantitative trait loci; pQTLs). PQTLs consistently replicated between the two cohorts. Features of pQTLs were compared to previously reported expression QTLs (eQTLs). Inference of causal relations of pQTL genotypes, biomarker measurements, and four clinical COPD phenotypes (airflow obstruction, emphysema, exacerbation history, and chronic bronchitis) were explored using conditional independence tests. We identified 527 highly significant (p 10% of measured variation in 13 protein biomarkers, with a single SNP (rs7041; p = 10−392) explaining 71%-75% of the measured variation in vitamin D binding protein (gene = GC). Some of these pQTLs [e.g., pQTLs for VDBP, sRAGE (gene = AGER), surfactant protein D (gene = SFTPD), and TNFRSF10C] have been previously associated with COPD phenotypes. Most pQTLs were local (cis), but distant (trans) pQTL SNPs in the ABO blood group locus were the top pQTL SNPs for five proteins. The inclusion of pQTL SNPs improved the clinical predictive value for the established association of sRAGE and emphysema, and the explanation of variance (R2) for emphysema improved from 0.3 to 0.4 when the pQTL SNP was included in the model along with clinical covariates. Causal modeling provided insight into specific pQTL-disease relationships for airflow obstruction and emphysema. In conclusion, given the frequency of highly significant local pQTLs, the large amount of variance potentially explained by pQTL, and the differences observed between pQTLs and eQTLs SNPs, we recommend that protein biomarker-disease association studies take into account the potential effect of common local SNPs and that pQTLs be integrated along with eQTLs to uncover disease mechanisms. Large-scale blood biomarker studies would also benefit from close attention to the ABO blood group