Does Reading-While-Listening Enhance Students' Reading Fluency? Preliminary Results from School Experiments in Rural Uganda

Although studies on the effects of Reading While Listening (RWL) to audiobooks on students' reading fluency is limited, the available emerging literature consistently demonstrates its favourable contribution to improve reading fluency. Since improving fluency is an important instructional goal of primary schools, understanding the role of RWL to audiobooks in improving reading fluency is essential. The goal of the study was to assess the impact of RWL to audiobooks on reading fluency. To achieve this goal, we conducted a randomized controlled experiment using forty six students enrolled in grade 3 at Hadassa Primary School in rural Mbale, Uganda.The significance of the study underscores the current inefficiencies within classrooms globally and the ease with which simple interventions can be implemented to improve fluency.  Limitations of the study are discussed. Keywords: Reading While Listening (RWL); reading fluency; randomized control trial; The Walking School Bus; Uganda; audioboo

Determinants of Adoption of Improved Crossbred Cattles: A Case Study of Suba and Laikipia Districts, Kenya

Recognizing that more than 10% of the Kenyan GDP and 50% of agricultural GDP are comprised of sales within the livestock subsector; the purpose of this research is to identify the determinants of adoption of improved crossbred cattle in rural Kenya. This research has important implications for increasing the dairy subsectors’ productivity, improving nutrient intake within rural Kenya and motivating higher rates of foreign direct investment in a sustainable, beneficial sector. We used a publicly available (www.ifpri.org) dataset called "Land Tenure, Agricultural Productivity and the Environment, 2001." A logistical regression analysis is employed to answer our research questions. The results showed that: family members education, having an extra job in addition to farming, and exposure to external market forces (was the farmer a local, or immigrant) all greatly contributed to the likelihood of adoption. This research aims to gnaw away at the ambiguity and lack of research associated with the Kenyan dairy sub-sector and aims to facilitate greater understanding and investment in the sector. Keywords: Adoption, Logistic regression, Kenya, Crossbreed cattl

Case report: response to the ERK1/2 inhibitor ulixertinib in BRAF D594G cutaneous melanoma.

Melanoma is characterized by oncogenic mutations in pathways regulating cell growth, proliferation, and metabolism. Greater than 80% of primary melanoma cases harbor aberrant activation of the mitogen-activated protein kinase kinase/extracellular-signal-regulated kinase (MEK/ERK) pathway, with oncogenic mutations in BRAF, most notably BRAF V600E, being the most common. Significant progress has been made in BRAF-mutant melanoma using BRAF and MEK inhibitors; however, non-V600 BRAF mutations remain a challenge with limited treatment options. We report the case of an individual diagnosed with stage III BRAF D594G-mutant melanoma who experienced an extraordinary response to the ERK1/2 inhibitor ulixertinib as fourth-line therapy. Ulixertinib was obtained via an intermediate expanded access protocol with unique flexibility to permit both single-agent and combination treatments, dose adjustments, breaks in treatment to undergo surgery, and long-term preventive treatment following surgical resection offering this patient the potential for curative treatment

Dark sectors 2016 Workshop: community report

This report, based on the Dark Sectors workshop at SLAC in April 2016, summarizes the scientific importance of searches for dark sector dark matter and forces at masses beneath the weak-scale, the status of this broad international field, the important milestones motivating future exploration, and promising experimental opportunities to reach these milestones over the next 5-10 years

Sequelae due to bacterial meningitis among African children: a systematic literature review

<p>Abstract</p> <p>Background</p> <p>African children have some of the highest rates of bacterial meningitis in the world. Bacterial meningitis in Africa is associated with high case fatality and frequent neuropsychological sequelae. The objective of this study is to present a comprehensive review of data on bacterial meningitis sequelae in children from the African continent.</p> <p>Methods</p> <p>We conducted a systematic literature search to identify studies from Africa focusing on children aged between 1 month to 15 years with laboratory-confirmed bacterial meningitis. We extracted data on neuropsychological sequelae (hearing loss, vision loss, cognitive delay, speech/language disorder, behavioural problems, motor delay/impairment, and seizures) and mortality, by pathogen.</p> <p>Results</p> <p>A total of 37 articles were included in the final analysis representing 21 African countries and 6,029 children with confirmed meningitis. In these studies, nearly one fifth of bacterial meningitis survivors experienced in-hospital sequelae (median = 18%, interquartile range (IQR) = 13% to 27%). About a quarter of children surviving pneumococcal meningitis and <it>Haemophilus influenzae </it>type b (Hib) meningitis had neuropsychological sequelae by the time of hospital discharge, a risk higher than in meningococcal meningitis cases (median = 7%). The highest in-hospital case fatality ratios observed were for pneumococcal meningitis (median = 35%) and Hib meningitis (median = 25%) compared to meningococcal meningitis (median = 4%). The 10 post-discharge studies of children surviving bacterial meningitis were of varying quality. In these studies, 10% of children followed-up post discharge died (range = 0% to 18%) and a quarter of survivors had neuropsychological sequelae (range = 3% to 47%) during an average follow-up period of 3 to 60 months.</p> <p>Conclusion</p> <p>Bacterial meningitis in Africa is associated with high mortality and risk of neuropsychological sequelae. Pneumococcal and Hib meningitis kill approximately one third of affected children and cause clinically evident sequelae in a quarter of survivors prior to hospital discharge. The three leading causes of bacterial meningitis are vaccine preventable, and routine use of conjugate vaccines could provide substantial health and economic benefits through the prevention of childhood meningitis cases, deaths and disability.</p

Seeding Science, Courting Conclusions: Reexamining the Intersection of Science, Corporate Cash, and the Law

Social scientists have expressed strong views on corporate influences over science, but most attention has been devoted to broad, Black/White arguments, rather than to actual mechanisms of influence. This paper summarizes an experience where involvement in a lawsuit led to the discovery of an unexpected mechanism: A large corporation facing a multibillion-dollar court judgment quietly provided generous funding to well-known scientists (including at least one Nobel prize winner) who would submit articles to "open," peer-reviewed journals, so that their "unbiased science" could be cited in an appeal to the Supreme Court. On balance, the corporation's most effective techniques of influence may have been provided not by overt pressure, but by encouraging scientists to continue thinking of themselves as independent and impartial

A review and report of a rare clinical entity: Intratonsillar abscess

Background: Intratonsillar abscess is a rare complication of tonsillitis. The number of reported cases in the literature is scarce. The clinical features can resemble tonsillitis or peritonsillar abscess. Recognition of this as a possible cause is important as management differs. Often imaging is required to make this distinction. The aim of this report is to help provide a comprehensive review of the literature on patients with intratonsillar abscess. In doing so a case is also presented. Method: Literature review and case review. Case review: We report the case of a previously well 40 year old man with an intratonsillar abscess. Imaging was required to make the diagnosis and patient was managed with incision and drainage together with empirical intravenous antibiotics. Conclusion: Intratonsillar abscess is rare. Although the distinction between tonsilitis, intratonsillar abscess and peritonsillar abscess is difficult there are symptoms and signs that may help the clinician make the differentiation. Imaging is often utilised to localise the abscess. To achieve a more rapid recovery procedural management seems to be necessary

Hydroxychloroquine for pre-exposure prophylaxis of COVID-19 in health care workers: a randomized, multicenter, placebo-controlled trial Healthcare Worker Exposure Response and Outcomes of Hydroxychloroquine (HERO-HCQ)

ABSTRACT: Objectives: To determine whether hydroxychloroquine (HCQ) is safe and effective at preventing COVID-19 infections among health care workers (HCWs). Methods: In a 1: 1 randomized, placebo-controlled, double-blind, parallel-group, superiority trial at 34 US clinical centers, 1360 HCWs at risk for COVID-19 infection were enrolled between April and November 2020. Participants were randomized to HCQ or matched placebo. The HCQ dosing included a loading dose of HCQ 600 mg twice on day 1, followed by 400 mg daily for 29 days. The primary outcome was a composite of confirmed or suspected COVID-19 clinical infection by day 30, defined as new-onset fever, cough, or dyspnea and either a positive SARS-CoV-2 polymerase chain reaction test (confirmed) or a lack of confirmatory testing due to local restrictions (suspected). Results: Study enrollment closed before full accrual due to recruitment challenges. The primary end point occurred in 41 (6.0%) participants receiving HCQ and 53 (7.8%) participants receiving placebo. No difference in the proportion of participants experiencing clinical infection (estimated difference of -1.8%, 95% confidence interval -4.6-0.9%, P = 0.20) was identified nor any significant safety issues. Conclusion: Oral HCQ taken as prescribed appeared safe among HCWs. No significant clinical benefits were observed. The study was not powered to detect a small but potentially important reduction in infection. Trial registration: NCT04334148