The Ursinus Weekly, March 15, 1973

Ursinus Board of Directors meets in regular Spring session; Discusses tax proposals, committee reports, appointments • USGA fills vacancies; 3 new members elected • USGA secures bike racks; readies for J-Board elections • Old snack bar to be transformed by ProTheatre into acting workshop • Editorial: It depends on your point of view • Focus: David Mowere • WRUC, radio voice of Ursinus, on the air 12 hours a day • Fidler on the wax: New L.P. a delight for Traffic fans • Letters to the editor: Union head happy; Female uproar • Bearettes lose at regionals; West Chester drops Boydies • Water wonders end seasonhttps://digitalcommons.ursinus.edu/weekly/1100/thumbnail.jp

The Ursinus Weekly, February 17, 1972

College Union reveals plans • Dr. John Jacob Heilemann, professor of physics, dies • UCC presents grant toward church goal • Lorelei 1972, Leap Year Fest • Lantern announces contest • Editorial: Dr. Heilemann • 242 students named to dean\u27s list last semester • USGA elects new officers • Faculty portrait: Dr. John J. Heilemann • Spotlight: Dean H. Lloyd Jones • U.C. hosts two forum programs; four more scheduled for Spring • Good season for UC Bears • UC women score high • Ursinus College\u27s Cattell honoredhttps://digitalcommons.ursinus.edu/weekly/1116/thumbnail.jp

The Ursinus Weekly, June 2, 1972

Campus Chest presents: You can\u27t take it with you • New gym named Helfferich Hall • U.C. receives $100,000 grant from Kresge Foundation • Ursinus to confer 261 degrees at June 4 commencement • Ursinus suffers blackout; Transformer explodes • Scrounge Lounge opens; Provides place for chat • Editorial: The year of optimism • U.C. arts festival attracts hundreds • ProTheatre presents: Marat / Sade • President presents Ronnie Hollyman • Object d\u27art appears; Graces Library steps • President Pettit approves 3rd U.S.G.A. open dorm proposal • Kevin Akey elected new USGA president • Renovations: a new look for Pfahler • Ursinus Meistersingers plan 34th annual tour • WRUC-FM presents Jaime Brockett concert • Ursinus math team ranked in top 20 • I.R.C. welcomes 120 students to M.U.N.C. on U.C. campus • A. Wyeth, H.C. Pitz, and J.W. Merriam receive honorary degrees • Obituaries: Dr. John Jacob Heilemann, professor of physics, dies; Dr. Helen T. Garrett dies; Mrs. Dorothy A. Towers dies; Longtime Paisley resident head • Swimmers, Snellbelles off to regionals • Snellbelles undefeated • Bears close season with 4-4 record • Messiah sung tonight; Annual U.C. tradition • Women enjoy freedom with extended curfew • Ursinus Harriers place second in Middle Atlantic Conferencehttps://digitalcommons.ursinus.edu/weekly/1125/thumbnail.jp

The Ursinus Weekly, December 9, 1971

Gulf Oil Corporation awards scholarships to U.C. science scholars • Scrounge Lounge opens; Provides place for chat • Traditional banquet takes on a new look • Seven Ursinus seniors named to Who\u27s who • Memorial service: Dr. John Vorrath • Ecological concern group sponsors recycling project • Editorial: False alarm; Scrounge! • Focus: Stan Talley • Messiah sung tonight; Annual U.C. tradition • Faculty portrait: Mr. Walter Marsteller • Administration answers • Ursinus presents gift of $1,500 to Collegeville • Francis Davis speaks at Sigma Xi meeting • Slumming it • Critic\u27s choice: Thanksgiving, Marcus Welby M.D., Jamie Brockett and hayrides • Spotlight: Mr. Philip Harvey • Bears even record; Future looks good • Their work is never done • Letter to the editor • Soccer season closes: 4 wins, 7 losses, 3 ties • USGA notes • Outing Club braves cold • Ursinus Harriers place second in Middle Atlantic Conferencehttps://digitalcommons.ursinus.edu/weekly/1114/thumbnail.jp

The Ursinus Weekly, November 18, 1971

Name contest for new student faculty lounge • U.C. announces soloists for annual Messiah performance • President presents Ronnie Hollyman • Helicopter comes to U.C.; Nightlights installed • Buddhi\u27s Follies at Valley Forge • Education office offers new plan • Editorial: Rumors • Focus: Eileen Shrager • Students of many backgrounds participate in Sunday seminar • The science of setback • Century II: A bird\u27s eye view • Letter to the editor • Faculty portrait: Mr. Taras Zakydalsky • Pre-med meeting • The Administration answers • Bears close season with 4-4 record • Ursinus hoopla • Snellbelles undefeated • Ursinus wrestlers are bears • Bears drop 4: 1 game to gohttps://digitalcommons.ursinus.edu/weekly/1113/thumbnail.jp

Recombinant tissue-type plasminogen activator versus a novel dosing regimen of urokinase in acute pulmonary embolism: a randomized controlled multicenter trial

AbstractThrombolysis of acute pulmonary embolism can be accomplished more rapidly and safely with 100 mg of recombinant human tissue-type plasminogen activator (rt-PA) (Activase) than with a conventional dose of urokinase (Abbokinase) given as a 4,400-U/kg bolus dose, followed by 4,400 U/kg per h for 24 h. To determine the effects of a more concentrated urokinase dose administered over a shorter time course, this trial enrolled 90 patients with baseline perfusion lung scans and angiographically documented pulmonary embolism. They were randomized to receive either 100 mg/2 h of rt-PA or a novel dosing regimen of urokinase: 3 million U/2 h with the initial 1 million U given as a bolus injection over 10 min. Both drugs were delivered through a peripheral vein.To assess efficacy after initiation of therapy, repeat pulmonary angiograms at 2 h were performed in 87 patients and then graded in a blinded manner by a panel of six investigators. Of the 42 patients allocated to rt-PA therapy, 79% showed angiographic improvement at 2 h, compared with 67% of the 45 patients randomized to urokinase therapy (95% confidence interval for the difference in these proportions [rt-PA minus urokinase] is −6.6% to 30.4%; p = 0.11). The mean change in perfusion lung scans between baseline and 24 h was similar for both treatments. Three patients (two treated with rt-PA and one with urokinase) had an intracranial hemorrhage, which was fatal in one.The results indicate that a 2-h regimen of rt-PA and a new dosing regimen of urokinase exhibit similar efficacy and safety for treatment of acute pulmonary embolism

A Characterization of Brain-Computer Interface Performance Trade-Offs Using Support Vector Machines and Deep Neural Networks to Decode Movement Intent

Laboratory demonstrations of brain-computer interface (BCI) systems show promise for reducing disability associated with paralysis by directly linking neural activity to the control of assistive devices. Surveys of potential users have revealed several key BCI performance criteria for clinical translation of such a system. Of these criteria, high accuracy, short response latencies, and multi-functionality are three key characteristics directly impacted by the neural decoding component of the BCI system, the algorithm that translates neural activity into control signals. Building a decoder that simultaneously addresses these three criteria is complicated because optimizing for one criterion may lead to undesirable changes in the other criteria. Unfortunately, there has been little work to date to quantify how decoder design simultaneously affects these performance characteristics. Here, we systematically explore the trade-off between accuracy, response latency, and multi-functionality for discrete movement classification using two different decoding strategies–a support vector machine (SVM) classifier which represents the current state-of-the-art for discrete movement classification in laboratory demonstrations and a proposed deep neural network (DNN) framework. We utilized historical intracortical recordings from a human tetraplegic study participant, who imagined performing several different hand and finger movements. For both decoders, we found that response time increases (i.e., slower reaction) and accuracy decreases as the number of functions increases. However, we also found that both the increase of response times and the decline in accuracy with additional functions is less for the DNN than the SVM. We also show that data preprocessing steps can affect the performance characteristics of the two decoders in drastically different ways. Finally, we evaluated the performance of our tetraplegic participant using the DNN decoder in real-time to control functional electrical stimulation (FES) of his paralyzed forearm. We compared his performance to that of able-bodied participants performing the same task, establishing a quantitative target for ideal BCI-FES performance on this task. Cumulatively, these results help quantify BCI decoder performance characteristics relevant to potential users and the complex interactions between them

Book reviews

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/42842/1/10734_2004_Article_BF00129421.pd

Budesonide Oral Suspension Improves Symptomatic, Endoscopic, and Histologic Parameters Compared With Placebo in Patients With Eosinophilic Esophagitis

BACKGROUND & AIMS: Pharmacologic treatment of eosinophilic esophagitis (EoE) is limited to off-label use of corticosteroids not optimized for esophageal delivery. We performed a randomized, controlled phase 2 trial to assess the ability of budesonide oral suspension (BOS), a novel muco-adherent topical steroid formulation, to reduce symptoms and esophageal eosinophilia in adolescents and adults with EoE. METHODS: In this multicenter, randomized, double-blind, placebo-controlled, parallel-group trial, 93 EoE patients between the ages of 11 and 40 years with dysphagia and active esophageal eosinophilia were randomized to receive either BOS 2 mg or placebo twice daily for 12 weeks. Co-primary outcomes were change in Dysphagia Symptom Questionnaire (DSQ) score from baseline, and proportion of patients with a histologic response (≤6 eosinophils/high-power field) after treatment. Endoscopic severity scores and safety parameters were assessed. RESULTS: At baseline, mean DSQ scores were 29.3 and 29.0, and mean peak eosinophil counts were 156 and 130 per hpf in the BOS and placebo groups, respectively. After treatment, DSQ scores were 15.0 and 21.5, and mean peak eosinophil counts were 39 and 113 per high-power field, respectively (P < .05 for all). For BOS vs placebo, change in DSQ score was -14.3 vs -7.5 (P = .0096), histologic response rates were 39% vs 3% (P < .0001), and change in endoscopic severity score was -3.8 vs 0.4 (P < .0001). Adverse events were similar between groups. CONCLUSIONS: Treatment with BOS was well tolerated in adolescent and young adult patients with EoE and resulted in improvement in symptomatic, endoscopic, and histologic parameters using validated outcome instruments. ClinicalTrials.gov ID NCT01642212