HS 0139+0559, HS 0229+8016, HS 0506+7725, and HS 0642+5049 : four new long-period cataclysmic variables

We present time-resolved optical spectroscopy and photometry of four relatively bright (V ∼ 14.0−15.5) long-period cataclysmic variables(CVs) discovered in the Hamburg Quasar Survey: HS 0139+0559, HS 0229+8016, HS 0506+7725, and HS 0642+5049. Their respective orbital periods, 243.69 ± 0.49 min, 232.550 ± 0.049 min, 212.7 ± 0.2 min, and 225.90 ± 0.23 min are determined from radial velocity and photometric variability studies. HS 0506+7725 is characterised by strong Balmer and He emission lines, short-period (∼10−20 min) flickering, and weak X-ray emission in the ROSAT All Sky Survey. The detection of a deep low state (B 18.5) identifies HS 0506+7725 as a member of the VY Scl stars. HS 0139+0559, HS 0229+8016, and HS 0642+5049 display thick-disc like spectra and no or only weak flickering activity. HS 0139+0559 and HS 0229+8016 exhibit clean quasi-sinusoidal radial velocity variations of their emission lines but no or very little orbital photometricvariability. In contrast, we detect no radial velocity variation in HS 0642+5049 but a noticeable orbital brightness variation. We identify all three systems either as UX UMa-type novalike variables or as Z Cam-type dwarf novae. Our identification of these four new systems underlines that the currently known sample of CVs is rather incomplete even for bright objects. The four new systems add to the clustering of orbital periods in the 3−4 h range found in the sample of HQS selected CVs, and we discuss the large incidence of magnetic CVs and VY Scl/SW Sex stars found in this period range among the known population of CVs

Dwarf novae in the Hamburg quasar survey : rarer than expected

Aims. We report the discovery of five new dwarf novae that were spectroscopically identified in the Hamburg Quasar Survey (HQS),and discuss the properties of the sample of new dwarf novae from the HQS. Methods. Follow-up time-resolved spectroscopy and photometry have been obtained to characterise the new systems. Results. The orbital periods determined from analyses of the radial velocity variations and/or orbital photometric variability are Porb 105.1min or Porb 109.9min for HS 0417+7445, Porb = 114.3 ± 2.7min for HS 1016+3412, Porb = 92.66 ± 0.17 min for HS 1340+1524, Porb = 272.317 ± 0.001 min for HS 1857+7127, and Porb = 258.02 ± 0.56 min for HS 2214+2845. HS 1857+7127 is found to be partially eclipsing. In HS 2214+2845 the secondary star of spectral type M3 ± 1 is clearly detected, and we estimate the distance to the system to be d = 390 ± 40 pc. We recorded one superoutburst of HS 0417+7445, identifying the system as a SUUMatype dwarf nova. HS 1016+3412 and HS 1340+1524 have rare outbursts, and their subtype is yet undetermined. HS 1857+7127 frequently varies in brightness and may be a ZCam-type dwarf nova. HS 2214+2845 is a UGem-type dwarf nova with a most likely cycle length of 71 d. Conclusions. To date, 14 new dwarf novae have been identified in the HQS. The ratio of short-period (3 h)systems of this sample is 1.3, much smaller compared to the ratio of 2.7 found for all known dwarf novae. The HQS dwarf novae display typically infrequent or low-amplitude outburst activity, underlining the strength of spectroscopic selection in identifying new CVs independently of their variability. The spectroscopic properties of short-period CVs in the HQS, newly identified and previously known, suggest that most, or possibly all of them are still evolving towards the minimum period. Their total number agrees with the predictions of population models within an order of magnitude. However, the bulk of all CVs is predicted to have evolved past the minimum period, and those systems remain unidentified. This suggests that those post-bounce systems have markedly weaker Hβ emission lines compared to the average known short-period CVs, and undergo no or extremely rare outbursts

Biopsy of breast cancer metastases: patient characteristics and survival

Abstract Background Discordance in hormone receptors (HR) and human epidermal growth factor receptor 2 (HER2) status between primary tumors and metastatic sites for breast cancer is well established. However, it is uncertain which patient-related factors lead to biopsy when metastases are suspected and whether having a biopsy impacts survival. Methods The medical charts of metastatic breast cancer (MBC) patients diagnosed January 2000-August 2014 were retrospectively reviewed. A biopsy was defined as a procedure where tissue was obtained and assessed for both HR and HER2. Both bivariate and multivariate analyses were performed to assess patient characteristics related to biopsy and whether having a biopsy was associated with improved survival. Results Of 409 patients suspected of having MBC, 165 (40%) had a biopsy, and 34% of these had discordant HR or HER2 status when compared to the initial diagnosis. In multivariate analysis, having a biopsy was associated with: recurrence in years 2010–2014, disease-free interval of > =3 years, stage 0-IIA at presentation, suspected locoregional recurrence, being HR+/HER2-, or missing HR/HER2 at diagnosis. A similar multivariate analysis revealed that having a biopsy was associated with improved survival (HR = 0.67, p = 0.002). The association of biopsy and improved survival was noted in specific subgroups: patients with missing HR and HER2 data at initial diagnosis (p = 0.001), those without metastases in liver, lung or brain (p = 0.001), and being younger than 70 years old at recurrence (p < 0.001). Conclusions Specific clinical factors were associated with biopsy at the time of suspected recurrence. Having a biopsy was associated with reduced mortality

Developmental consequences of perinatal cannabis exposure: behavioral and neuroendocrine effects in adult rodents

Cannabis is the most commonly used illicit drug among pregnant women. Since the endocannabinoid system plays a crucial role in brain development, maternal exposure to cannabis derivatives might result in long-lasting neurobehavioral abnormalities in the exposed offspring. It is difficult to detect these effects, and their underlying neurobiological mechanisms, in clinical cohorts, because of their intrinsic methodological and interpretative issues. The present paper reviews relevant rodent studies examining the long-term behavioral consequences of exposure to cannabinoid compounds during pregnancy and/or lactation. Maternal exposure to even low doses of cannabinoid compounds results in atypical locomotor activity, cognitive impairments, altered emotional behavior, and enhanced sensitivity to drugs of abuse in the adult rodent offspring. Some of the observed behavioral abnormalities might be related to alterations in stress hormone levels induced by maternal cannabis exposure. There is increasing evidence from animal studies showing that cannabinoid drugs are neuroteratogens which induce enduring neurobehavioral abnormalities in the exposed offspring. Several preclinical findings reviewed in this paper are in line with clinical studies reporting hyperactivity, cognitive impairments and altered emotionality in humans exposed in utero to cannabis. Conversely, genetic, environmental and social factors could also influence the neurobiological effects of early cannabis exposure in humans

Long-Baseline Neutrino Facility (LBNF) and Deep Underground Neutrino Experiment (DUNE) Conceptual Design Report Volume 2: The Physics Program for DUNE at LBNF

The Physics Program for the Deep Underground Neutrino Experiment (DUNE) at the Fermilab Long-Baseline Neutrino Facility (LBNF) is described

Neural antecedents of self-initiated actions in secondary motor cortex

The neural origins of spontaneous or self-initiated actions are not well understood and their interpretation is controversial. To address these issues, we used a task in which rats decide when to abort waiting for a delayed tone. We recorded neurons in the secondary motor cortex (M2) and interpreted our findings in light of an integration-to-bound decision model. A first population of M2 neurons ramped to a constant threshold at rates proportional to waiting time, strongly resembling integrator output. A second population, which we propose provide input to the integrator, fired in sequences and showed trial-to-trial rate fluctuations correlated with waiting times. An integration model fit to these data also quantitatively predicted the observed inter-neuronal correlations. Together, these results reinforce the generality of the integration-to-bound model of decision-making. These models identify the initial intention to act as the moment of threshold crossing while explaining how antecedent subthreshold neural activity can influence an action without implying a decision.info:eu-repo/semantics/publishedVersio

Methods of probing the interactions between small molecules and disordered proteins

It is generally recognized that a large fraction of the human proteome is made up of proteins that remain disordered in their native states. Despite the fact that such proteins play key biological roles and are involved in many major human diseases, they still represent challenging targets for drug discovery. A major bottleneck for the identification of compounds capable of interacting with these proteins and modulating their disease-promoting behaviour is the development of effective techniques to probe such interactions. The difficulties in carrying out binding measurements have resulted in a poor understanding of the mechanisms underlying these interactions. In order to facilitate further methodological advances, here we review the most commonly used techniques to probe three types of interactions involving small molecules: (1) those that disrupt functional interactions between disordered proteins; (2) those that inhibit the aberrant aggregation of disordered proteins, and (3) those that lead to binding disordered proteins in their monomeric states. In discussing these techniques, we also point out directions for future developments.Gabriella T. Heller is supported by the Gates Cambridge Trust Scholarship. Francesco A. Aprile is supported by a Senior Research Fellowship award from the Alzheimer’s Society, UK (grant number 317, AS-SF-16-003)

The DUNE Far Detector Interim Design Report, Volume 3: Dual-Phase Module

The DUNE IDR describes the proposed physics program and technical designs of the DUNE far detector modules in preparation for the full TDR to be published in 2019. It is intended as an intermediate milestone on the path to a full TDR, justifying the technical choices that flow down from the high-level physics goals through requirements at all levels of the Project. These design choices will enable the DUNE experiment to make the ground-breaking discoveries that will help to answer fundamental physics questions. Volume 3 describes the dual-phase module's subsystems, the technical coordination required for its design, construction, installation, and integration, and its organizational structure