19 research outputs found
MMP-13 Selective Alpha-sulfone Hydroxamates: Identification of Selective P1\u27 Amides
Get PDFContinuing our interest in designing compounds preferentially potent and selective for MMP-13, we report on a series of hydroxamic acids with a flexible amide P1\u27 substituents. We identify an amide which spares both MMP-1 and -14, and shows \u3e500 fold selectivity for MMP-13 versus MMP-2 and -8
Identification, synthesis and SAR of amino substituted pyrido[3,2b]pyrazinones as potent and selective PDE5 inhibitors
Get PDFDiels-Alder Approach to Tetra-Ortho-Substituted Biaryls Employing Propargylic Tertiary Alcohols as Dienophiles
No full textSynthesis, Coordination Chemistry, and Catalytic Application of a Novel Unsymmetrical P/O Ferrocenediyl Ligand
No full textTunable dual-emitting shell-crosslinked nano-objects as single-component ratiometric pH-sensing materials
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Diels-Alder Approach for the Construction of Halogenated, o-Nitro Biaryl Templates and Application to the Total Synthesis of the Anti-HIV Agent Siamenol
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Oligonucleotides Containing 6-Aza-2-deoxyuridine: Synthesis, Nucleobase Protection, pH-Dependent Duplex Stability, and Metal-DNA Formation
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