38 research outputs found
Evaluation of physical activity programmes for the elderly - exploring the lessons from other sectors and examining the general characteristics of the programmes
<p>Abstract</p> <p>Background</p> <p>In Portugal, there are several physical activity (PA) programmes for elderly people developed by the local government. The importance of these programmes has been increasing since the evidence has shown that this type of health promotion interventions may reduce the deleterious effects of the ageing process. However, no study has already identified the general characteristics of these programmes nor if they use any scheme to assess the quality of the service provided. A widely-used scheme is the EFQM Excellence Model, which will be in the core of our present work. Thus, the main aims of this preliminary study were 1) to identify the general characteristics of the PA programmes developed by the Portuguese Local Public Administration 2) to determine the extent of implementation of quality initiatives in these programmes.</p> <p>Methods</p> <p>Data were collected by an on-line questionnaire sent to all Continental Municipalities (n = 278). Categorical data were expressed as absolute counts and percentages. Continuous data were expressed as the mean and SD. An open-ended question was analysed using qualitative content analysis with QSR NVivo software. Associations between categorical variables were tested by the use of contingency tables and the calculation of chi-square tests. Significance level was set at p ≤ 0.05.</p> <p>Results</p> <p>Results showed: i) a total of 125 PA programmes were identified in the 18 districts of the Portugal mainland; ii) the main goal of the majority (95.2%) was the participants' health promotion; iii) different characteristics of the programmes were found according to different regions of the country; iv) certain characteristics of the programmes were associated to the existence of other features; v) only one PA programme developed quality initiatives.</p> <p>Conclusions</p> <p>In conclusion, although there are many PA programmes for elderly people spread throughout the country, aiming at improving the health of participants, the overwhelming majority does not adopt quality control initiatives. Considering that the quality of a service increases customer satisfaction, the continuous quality improvement of the PA programmes for elderly people should therefore be implemented since they can be useful and critical for elderly satisfaction and adherence.</p
Podocyte GSK3 is an evolutionarily conserved critical regulator of kidney function
Albuminuria affects millions of people, and is an independent risk factor for kidney failure, cardiovascular morbidity and death. The key cell that prevents albuminuria is the terminally differentiated glomerular podocyte. Here we report the evolutionary importance of the enzyme Glycogen Synthase Kinase 3 (GSK3) for maintaining podocyte function in mice and the equivalent nephrocyte cell in Drosophila. Developmental deletion of both GSK3 isoforms (α and β) in murine podocytes causes late neonatal death associated with massive albuminuria and renal failure. Similarly, silencing GSK3 in nephrocytes is developmentally lethal for this cell. Mature genetic or pharmacological podocyte/nephrocyte GSK3 inhibition is also detrimental; producing albuminuric kidney disease in mice and nephrocyte depletion in Drosophila. Mechanistically, GSK3 loss causes differentiated podocytes to re-enter the cell cycle and undergo mitotic catastrophe, modulated via the Hippo pathway but independent of Wnt-β-catenin. This work clearly identifies GSK3 as a critical regulator of podocyte and hence kidney functio
Down regulation of the expression and function of the transporter associated with antigen processing in murine tumor cell lines expressing IL-10
Informational heritage, sustainable Development and tourism: the Urban Route of the Fisherman’s Project
The Fisherman’s Route reflects the interinstitutional collaboration between the Higher Institute of Accounting and Administration of Porto and the Parish Council of Vila do Conde, developed as part of a sustainable tourism project based on the largest fishing community in the Country: Poça da Barca and Caxinas. It aims to safeguard cultural and immaterial heritage, promoting the transfer of knowledge using the skills of the information professional acquired in the degree in Sciences and Technologies of Documentation and Information. Through the application of semi-structured interviews and documentary analysis, the identification of the relevant information was carried out, regarding informational heritage, ethnographic, cultural, religious, architectural, related to shipbuilding and the clothing and gastronomy. The results are: the creation of the project logo; the creation of merchandising and a glossary of the typical language of the caxineiro; the outline of a small pedestrian route; the creation of a Facebook page and the re-creation of certain community traditions as well as an online portal and an app designed for tourists. The project assumes itself as a model of great importance in the sustainable development based on tourist initiatives, valuing the traditions and the memory, preserving the informational heritage connected to the fishing activity of those communities.info:eu-repo/semantics/publishedVersio