Guiding-center dynamics of vortex dipoles in Bose-Einstein condensates

A quantized vortex dipole is the simplest vortex molecule, comprising two counter-circulating vortex lines in a superfluid. Although vortex dipoles are endemic in two-dimensional superfluids, the precise details of their dynamics have remained largely unexplored. We present here several striking observations of vortex dipoles in dilute-gas Bose-Einstein condensates, and develop a vortex-particle model that generates vortex line trajectories that are in good agreement with the experimental data. Interestingly, these diverse trajectories exhibit essentially identical quasi-periodic behavior, in which the vortex lines undergo stable epicyclic orbits.Comment: 4 pages, 2 figure

A Mixed-Method Analysis of Fatal Attacks on Police by Far-Right Extremists

Several recent high-profile homicides of police officers have brought increased attention to issues of far-right extremist violence in the United States. We still, however, know very little about why (and how) certain encounters between far-right extremists and police result in violence. To fill this research gap, we conduct a mixed-method analysis of far-right antipolice homicides based on quantitative and qualitative data from the U.S. Extremist Crime Database. We begin by categorizing cases based on key aspects of homicide storylines. We then comparatively analyze attributes of event precursor, transaction, and aftermath stages across four storyline categories. Finally, a case study is purposively selected to follow-up on each storyline category to better capture the nuances of fluid homicide processes. Our findings have important implications for identifying triggering events, escalation factors, and other situated sets of conditions and circumstances that contribute to deadly outcomes for police officers

Understanding and Applying SAR to Ideological and Nation- State-Sponsored Cybercrimes

The use of computer hacking, malicious software, and other forms of cyberattacks against U.S. infrastructure has increased dramatically since the 1990s. Many of these attacks target corporations and individuals for instrumental economic gain, such as the theft of personal information for use in fraud. Ideologically motivated attacks also occur, though the degree to which they are understood or documented is generally limited. For instance, jihadi groups have expressed an interest in cyberattacks since the early 2000s (see Holt et al., 2022). Similarly, DHS (2009) noted in the late 2000s that they expected cyberattacks from environmental or animal liberation-focused groups to increase. Attacks not only originate from individual actors, but also from nation-state-sponsored actors who seek to further the political and economic interests of their governments

Integrating genetic and oral histories of Southwest Indian populations

India is home to thousands of ethno-linguistically distinct groups, many maintaining strong self-identities that derive from oral traditions and histories. However, these traditions and histories are only partially documented and are in danger of being lost over time. More recently, genetic studies have established the existence of ancestry gradients derived from both western and eastern Eurasia as well as evidence of practices such as endogamy and consanguinity, revealing complexity in the regional population structure with consequences for the health landscape of local populations. Despite the increase in genome-wide data from India, there is still sparse sampling across finer-scale geographic regions leading to gaps in our understanding of how and when present-day genetic structure came into existence. To address the gaps in genetic and oral histories, we analyzed whole-genome sequences of 70 individuals from Southwest India identifying as Bunt, Kodava, and Nair—populations that share unique oral histories and origin narratives—and 78 recent immigrants to the United States with Kodava ancestry as part of a community-led initiative. We additionally generated genome-wide data from 10 individuals self-identifying as Kapla, a population from the same region that is socio-culturally different to the other three study populations. We supplemented existing but limited anthropological records on these populations with oral history accounts narrated by community members and non-member contacts during sampling and subsequent community engagement. Overall, we find that components of genetic ancestry are relatively homogeneous among the Bunt, Kodava, and Nair populations and comparable to neighboring populations in India, which motivates further investigation of non-local origin narratives referenced in their oral histories. A notable exception is the Kapla population, with a higher proportion of ancestry represented in the Onge from the Andaman Islands, similar to several South Indian tribal populations. Utilizing haplotype-based methods, we find latent genetic structure across South India, including the sampled populations available under aCC-BY-NC-ND 4.0 International license.was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made bioRxiv preprint doi: https://doi.org/10.1101/2022.07.06.498959; this version posted July 7, 2022. The copyright holder for this preprint (which 2 from Southwest India, suggesting more recent population structure between geographically proximal populations in the region. This study represents an attempt for community-engaged anthropological and genetic investigations in India and presents results from both sources, underscoring the need to recognize that oral and genetic histories should not be expected to overlap. Ultimately, oral traditions and unique self-identities, such as those held close by some of the study populations, warrant more community-driven anthropological investigations to better understand how they originate and their relationship to genetic histories

Daclatasvir in combination with asunaprevir and beclabuvir for hepatitis C virus genotype 1 infection with compensated cirrhosis

Importance Effective and well-tolerated, interferon-free regimens are needed for treatment of patients with chronic hepatitis C virus (HCV) infection and cirrhosis. Objective All-oral therapy with daclatasvir (nonstructural protein 5A [NS5A] inhibitor), asunaprevir (NS3 protease inhibitor), and beclabuvir (nonnucleoside NS5B inhibitor), with or without ribavirin, was evaluated in patients with HCV genotype 1 infection and compensated cirrhosis. Design, Setting, and Participants The UNITY-2 study was conducted between December 2013 and October 2014 at 49 outpatient sites in the United States, Canada, France, and Australia. Patients were treated for 12 weeks, with 24 weeks of follow-up after completion of treatment. Adult patients with cirrhosis were enrolled in 2 cohorts: HCV treatment-naive or HCV treatment-experienced. Statistical analyses were based on historical controls; there were no internal controls. Interventions All patients received twice-daily treatment with the fixed-dose combination of daclatasvir (30 mg), asunaprevir (200 mg), and beclabuvir (75 mg). In addition, patients within each cohort were stratified according to HCV genotype 1 subtype (1a or 1b) and randomly assigned (1:1) to receive double-blinded weight-based ribavirin (1000-1200 mg/d) or matching placebo. Main Outcomes and Measures Sustained virologic response at posttreatment week 12 (SVR12). Results One hundred twelve patients in the treatment-naive group and 90 patients in the treatment-experienced group were treated and included in the analysis. Enrolled patients were 88% white with a median age of 58 years (treatment-naive group) or 60 years (treatment-experienced group); 74% had genotype 1a infection. SVR12 rates were 98% (97.5% CI, 88.9%-100%) for patients in the treatment-naive group and 93% (97.5% CI, 85.0%-100.0%) for those in the treatment-experienced group when ribavirin was included in the regimen. With the fixed-dose combination alone, response rates were 93% (97.5% CI, 85.4%-100.0%) for patients in the treatment-naive group and 87% (97.5% CI, 75.3%-98.0%) for those in the treatment-experienced group. Three serious adverse events were considered to be treatment related and there were 4 adverse event–related discontinuations. Treatment-emergent grade 3 or 4 alanine aminotransferase elevations were observed in 4 patients, of which 1 had concomitant total bilirubin elevation. Conclusions and Relevance In this open-label uncontrolled study, patients with chronic HCV genotype 1 infection and cirrhosis who received a 12-week oral fixed-dose regimen of daclatasvir, asunaprevir, and beclabuvir, with or without ribavirin, achieved high rates of SVR12

The radicalization of democracy: conflict, social movements and terrorism

The idea of democracy is being championed across the world, with some fifty new countries embracing this type of political system between 1974 and 2011 (Freedom House, 2016). Simultaneously, however, dissatisfaction has grown due to the perceived incapacity of democracy to deal with collective problems, hence the necessity to reconfigure it and redraw some of its principles. This paper links the analysis of the recent evolution of democratic systems with the trajectory of socio-political conflicts and the changing features of contemporary terrorism. It examines, therefore, two intertwined phenomena, namely the radicalization of democracy and the radicalization of the other. It concludes by stressing that encouraging dissent and heeding contentious claims made by social movements may be one way of mitigating both types of radicalization. Embedded in the tradition of critical criminology, this paper attempts to demonstrate that only by outflanking conventional categories of analysis can the criminological community aspire to grasp such thorny contemporary phenomena

Decoupling Environment-Dependent and Independent Genetic Robustness across Bacterial Species

The evolutionary origins of genetic robustness are still under debate: it may arise as a consequence of requirements imposed by varying environmental conditions, due to intrinsic factors such as metabolic requirements, or directly due to an adaptive selection in favor of genes that allow a species to endure genetic perturbations. Stratifying the individual effects of each origin requires one to study the pertaining evolutionary forces across many species under diverse conditions. Here we conduct the first large-scale computational study charting the level of robustness of metabolic networks of hundreds of bacterial species across many simulated growth environments. We provide evidence that variations among species in their level of robustness reflect ecological adaptations. We decouple metabolic robustness into two components and quantify the extents of each: the first, environmental-dependent, is responsible for at least 20% of the non-essential reactions and its extent is associated with the species' lifestyle (specialized/generalist); the second, environmental-independent, is associated (correlation = ∼0.6) with the intrinsic metabolic capacities of a species—higher robustness is observed in fast growers or in organisms with an extensive production of secondary metabolites. Finally, we identify reactions that are uniquely susceptible to perturbations in human pathogens, potentially serving as novel drug-targets

Does Private Islamic Schooling Promote Terrorism? An Analysis of the Educational Background of Successful American Homegrown Terrorists

Some commentators argue that private religious schools are less likely to inculcate the attributes of good citizenship than traditional public schools, specifically proposing that private Islamic schools are relatively more likely to produce individuals sympathetic to terrorism. This study offers a preliminary examination of the question by studying the educational backgrounds of Western educated terrorists. While data are limited, in accord with prior work findings indicate the vast majority of both Islamic and reactionary terrorists attended traditional public schools and had no religious education; hence findings suggest that early religious training and identification may actually encourage prosocial behavior