An information states blackboard as an intelligent querying interface for snow and avalanche data

We present the graph-based querying paradigm used in the Regional Avalanche Information and Forecasting System (RAIFoS) for the collection and analysis of snow and weather related physical parameters in the Swiss Alps. The querying paradigm relies upon the issue of interactively constructing a semantically valid query graph on an Information States Blackboard as guided by meta-data elements standing for interpretations of conceptual model, data values and/or operations. The meta-data elements constitute the terms of a meta-data-driven query language (MDDQL) the interpretation of which is done interactively relying on a kind of finite state automaton

A Catalog of Digital Images of 113 Nearby Galaxies

We present a digital catalog of images of 113 galaxies in this paper. These galaxies are all nearby, bright, large and well resolved. All images were recorded with charge coupled devices (CCDs) at the Palomar Observatory with the 1.5 meter telescope and at the Lowell Observatory with the 1.1 meter telescope. At Palomar we used the Thuan--Gunn g, r and i photometric bands to take 3 images each of 31 spiral galaxies; at Lowell we used the B_J and R bands (2 images per galaxy) of the photometric system by Gullixson et al. (1995) to observe 82 spirals and ellipticals. The galaxies were selected to span the Hubble classification classes. All data are photometrically calibrated with foreground stars removed. Important data on these galaxies published in the "Third Reference Catalog of Bright Galaxies" (RC3) are recorded in the FITS file headers. All files are available through anonymous FTP from ftp://astro.princeton.edu/, through WWW at http://astro.princeton.edu/~frei/galaxy_catalog.html, and Princeton University Press will soon publish the data on CD-ROM.Comment: uuencoded compressed tar archive of postscript files (paper + 2 tables + 7 figures) Accepted for publication in the Astronomical Journa

Induction of somatic mutation and recombination by four inhibitors of eukaryotic topoisomerases assayed in the wing spot test of Drosophila melanogaster

Four inhibitors of eukaryotic topoisomerases were investigated for genotoxic effects in the wing spot test of Drosophila melanogaster. As a somatic mutation and recombination test (SMART) this assay assesses mitotic recombination and mutational events of various kinds. We studied camptothecin as a topoisomerase I inhibitor, as well as ellipticine as an intercalating inhibitor and teniposide and etoposide as two non-intercalating inhibitors of topoisomerase II. Wing spots were induced in flies trans-heterozygous for the recessive wing cell markers multiple wing hairs (mwh) and flare (flr3) as well as in flies heterozygous for mwh and the multiply inverted TM3 balancer chromosome. All four compounds proved significantly genotoxic in this test The spot induction frequencies formally standardized to the millimolar unit of exposure dose decreased in the order camptothecin > teniposide > ellipticine ≳ etoposide in the mwh/flr3 inversion-free genotype. In the mwh/TM3 genotype, in which mitotic crossing over is suppressed because of the inversion-heterozygosity, the observed spot frequencies were considerably reduced, but to different extents. In this genotype, spot induction by ellipticine was not statistically significant, and it was determined that >99% of the spots are due to mitotic recombination in mwh/flr3 flies. For the other compounds, spot induction in the inversion-heterozygous genotype was significant. The relative contribution of recombination to total spot induction in the inversion-free genotype was 88% for camptothecin. It was significantly lower for the two epipodophyllotoxins teniposide (71%) and etoposide (59%). Only suggestions can be proffered at present as to how these proportions could be related to the primary damage produced by the respective compounds on the chromosome

Mantle heterogeneity during the formation of the North Atlantic Igneous Province: Constraints from trace element and Sr-Nd-Os-O isotope systematics of Baffin Island picrites

Sr-Nd-Os-O isotope and major and trace element data from ~62 Ma picrites from Baffin Island constrain the composition of mantle sources sampled at the inception of North Atlantic Igneous Province (NAIP) magmatism. We recognize two compositional types. Depleted (N-type) lavas have low 87Sr/86Sri (0.702990–0.703060) and 187Os/188Osi (0.1220–0.1247) and high 143Nd/144Ndi (0.512989–0.512999) and are depleted in incompatible elements relative to primitive mantle. Enriched (E-type) lavas have higher 87Sr/86Sri (0.703306–0.703851) and 187Os/188Osi (0.1261–0.1303), lower 143Nd/144Ndi (0.512825–0.512906), and incompatible element concentrations similar to, or more enriched than, primitive mantle. There is also a subtle difference in oxygen isotope composition; E-type lavas are marginally lower in δ18Oolivine value (5.16–4.84‰) than N-type lavas (5.15–5.22‰). Chemical and isotopic variations between E- and N-type lavas are inconsistent with assimilation of crust and/or subcontinental lithospheric mantle and appear to instead reflect mixing between melts derived from two distinct mantle sources. Strontium-Nd-O isotope compositions and incompatible trace element abundances of N-type lavas suggest these are largely derived from the depleted upper mantle. The 187Os/188Osi ratios of N-type lavas can also be explained by such a model but require that the depleted upper mantle had γOs of approximately −5 to −7 at 62 Ma. This range overlaps the lowest γOs values measured in abyssal peridotites. Baffin Island lava compositions are also permissive of a model involving recharging of depleted upper mantle with 3He-rich material from the lower mantle (Stuart et al., Nature, 424, 57–59, 2003), with the proviso that recharge had no recognizable effect on the lithophile trace element and Sr-Nd-Os-O isotope composition. The origin of the enriched mantle component sampled by Baffin Island lavas is less clear but may be metasomatized and high-temperature-altered recycled oceanic lithosphere transported within the proto Iceland plume. Differences between Baffin Island lavas and modern Icelandic basalts suggest that a range of enriched and depleted mantle sources have been tapped since the inception of magmatism in the province. Similarities between Baffin Island lavas erupted and those of similar age from East and West Greenland also suggest that the enriched component in Baffin Island lavas may have been sampled by lavas erupted over a wide geographic range

Vaskulärer Zugang in der Kindernotfallanästhesie

Zusammenfassung: Zum Thema des schwierigen intervenösen Zugangs bei pädiatrischen Notfallsituationen existieren erstaunlich wenige Angaben in der Literatur. "Wie machen es die Anderen?" war die Motivationsgrundlage für eine Umfrage bei in Kinderanästhesie erfahrenen Anästhesisten. Insgesamt 89Fragebögen wurden an die Leiter der Weiterbildungsstätten für Anästhesie in der Schweiz und an alle Mitglieder der Schweizerischen Gesellschaft für Kinderanästhesie verschickt. Anhand von 2Fallbeispielen (FallA: nicht nüchternes Kleinkind mit einer Radiusfraktur, FallB: Säugling mit hohem Ileus) wurde das weitere Vorgehen nach 2-3 erfolglosen peripheren Punktionsversuchen erfragt. Die Beantwortung ergab, dass die meisten der Befragten in beiden Situationen zunächst weitere periphere Venenpunktionen vornehmen werden. Falls diese Versuche erfolglos bleiben, wird beim Kleinkind mit der Radiusfraktur eine intramuskuläre oder inhalative Anästhesieeinleitung befürwortet. Bei dem Säugling mit Ileus wird versucht, für die Anästhesieeinleitung einen intraossären oder zentralvenösen Zugang (V.femoralis) zu legen. Aufgrund der Resultate der Umfrage und einer Literaturrecherche wird eine Prioritätenliste zu den wichtigsten vaskulären Zugängen und alternativen Anästhesieeinleitungsmethoden in der pädiatrischen Notfallsituation vorgeschlage

Contribution of Lake-Effect Snow to the Catskill Mountains Snowpack

Meltwater from snow that falls in the Catskill Mountains in southern New York contributes to reservoirs that supply drinking water to approximately nine million people in New York City. Using the NOAA National Ice Centers Interactive Multisensor Snow and Ice Mapping System (IMS) 4km snow maps, we have identified at least 32 lake-effect (LE) storms emanating from Lake Erie andor Lake Ontario that deposited snow in the CatskillDelaware Watershed in the Catskill Mountains of southern New York State between 2004 and 2017. This represents a large underestimate of the contribution of LE snow to the Catskills snowpack because many of the LE snowstorms are not visible in the IMS snow maps when they travel over snow-covered terrain. Most of the LE snowstorms that we identified originate from Lake Ontario but quite a few originate from both Erie and Ontario, and a few from Lake Erie alone. Using satellite, meteorological and reanalysis data we identify conditions that contributed to LE snowfall in the Catskills. Clear skies following some of the storms permitted measurement of the extent of snow cover in the watershed using multiple satellite sensors. IMS maps tend to overestimate the extent of snow compared to MODerate resolution Imaging Spectroradiometer (MODIS) and Landsat-derived snow-cover extent maps. Using this combination of satellite and meteorological data, we can begin to quantify the important contribution of LE snow to the Catskills Mountain snowpack. Changes that are predicted in LE snowfall from the Great Lakes could impact the distribution of rain vs snow in the Catskills which may affect future reservoir operations in the NYC Water Supply System

Improved serodiagnosis of alveolar echinococcosis of humans using an in vitro-produced Echinococcus multilocularis antigen

Serology is an important tool for the diagnosis of alveolar echinococcosis (AE) in humans. In order to improve serodiagnostic performance, we have developed an in vitro-produced Echinococcus mulilocularis metacestode vesicle fluid (EmVF) antigen for application in an immunoblot assay. Immunoblot analysis of EmVF revealed an abundant immunoreactive band triplet of 20-22kDa, achieving a sensitivity of 100% based on the testing of sera from 62 pre-operative and pre-treatment cases of active and inactive AE. Thus, the EmVF-immunoblotting allowed the specific detection of cases seronegative by the Em2- and/or EmII/3-10-ELISA, usually attributable to abortive, inactive cases of AE. The specificity of the EmVF-immunoblotting did not allow discrimination between AE and cystic echinococcosis (CE) but was 100% with respect to non-Echinococcus parasitic infections or cancer malignancies. Based on the findings of this study, it is recommended that the current ELISA test combination (Em2- and II/3-10-ELISA) be complemented with EmVF-immunoblotting, allowing an improved diagnosis of both clinical and subclinical forms of AE, including those associated with E. multilocularis-specific antibody reactivities not detectable by ELIS