8,651 research outputs found

    Social and General Intelligence Improves Collective Action in a Common Pool Resource System

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    On a planet experiencing global environmental change, the governance of natural resources depends on sustained collective action by diverse populations. Engaging in such collective action can only build upon the foundation of human cognition in social–ecological settings. To help understand this foundation, we assess the effect of cognitive abilities on the management of a common pool resource. We present evidence that two functionally distinct cognitive abilities, general and social intelligence, improve the ability of groups to manage a common pool resource. Groups high in both forms of intelligence engage in more effective collective action that is also more consistent, despite social or ecological change. This result provides a foundation for integrating the effects of cognitive abilities with other dimensions of cognitive diversity to explain when groups will and will not sustainably govern natural resources

    Stakeholder Theory and Marketing: Moving from a Firm-Centric to a Societal Perspective

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    This essay is inspired by the ideas and research examined in the special section on “Stakeholder Marketing” of the Journal of Public Policy & Marketing in 2010. The authors argue that stakeholder marketing is slowly coalescing with the broader thinking that has occurred in the stakeholder management and ethics literature streams during the past quarter century. However, the predominant view of stakeholders that many marketers advocate is still primarily pragmatic and company centric. The position advanced herein is that stronger forms of stakeholder marketing that reflect more normative, macro/societal, and network-focused orientations are necessary. The authors briefly explain and justify these characteristics in the context of the growing “prosociety” and “proenvironment” perspectives—orientations that are also in keeping with the public policy focus of this journal. Under the “hard form” of stakeholder theory, which the authors endorse, marketing managers must realize that serving stakeholders sometimes requires sacrificing maximum profits to mitigate outcomes that would inflict major damage on other stakeholders, especially society

    Polymers, Encapsulation, and Artifical Organs (Report on Session 26.0)

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    Artificial Organs " at the Fourth International Symposium on Neurotransplantation consisted of five presentations examining the possibility that polymer capsules with or without cells could have therapeutic application for various neurological diseases. Dr. Robert Langer of the Massachusetts Institute of Technology provided an introduction to the use of polymers as systems for controlled release, long-term drug delivery/4/. Some of these systems are currently in use for the treatment of ophthalmic diseases, tobacco addiction, and birth control, and can continuously release drugs for over one year. Of interest is the use of these slow releasing polymers for delivering drugs and chemical

    Management Theory and Social Welfare: Contributions and Challenges

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    In this Introduction to the Special Topic Forum on Management Theory and Social Welfare, we first provide an overview of the motivation behind the special issue. We then highlight the contributions of the six articles that make up this forum and identify some common themes. We also suggest some reasons why social welfare issues are so difficult to address in the context of management theory. In addition, we evaluate means of assessing social welfare and urge scholars not to make (or imply) unwarranted “wealth creation” claims

    Technical Characteristics of a Novel Helical-Groove Traveling-Wave Tube Structure

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    Experimental measurements of the dispersion characteristics of a C-band helix structure were carried out and compared to the dispersion characteristics found from a helix model using the three-dimensional electromagnetic computer code MAFIA. A conceptually novel design comprising a helical thread of the same pitch and inner diameter in a cylindrical waveguide also were calculated using the MAFIA code. The helical-groove structure exhibits a smaller bandwidth but at a much higher frequency range than the traditional helical structure for similar physical dimensions. It is physically more robust in construction. The interaction impedance also compares favorably with those of the conventional structure

    Rapid in vivo forward genetic approach for identifying axon death genes in Drosophila

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    Axons damaged by acute injury, toxic insults, or neurodegenerative diseases execute a poorly defined autodestruction signaling pathway leading to widespread fragmentation and functional loss. Here, we describe an approach to study Wallerian degeneration in the Drosophila L1 wing vein that allows for analysis of axon degenerative phenotypes with single-axon resolution in vivo. This method allows for the axotomy of specific subsets of axons followed by examination of progressive axonal degeneration and debris clearance alongside uninjured control axons. We developed new Flippase (FLP) reagents using proneural gene promoters to drive FLP expression very early in neural lineages. These tools allow for the production of mosaic clone populations with high efficiency in sensory neurons in the wing. We describe a collection of lines optimized for forward genetic mosaic screens using MARCM (mosaic analysis with a repressible cell marker; i.e., GFP-labeled, homozygous mutant) on all major autosomal arms ( approximately 95% of the fly genome). Finally, as a proof of principle we screened the X chromosome and identified a collection eight recessive and two dominant alleles of highwire, a ubiquitin E3 ligase required for axon degeneration. Similar unbiased forward genetic screens should help rapidly delineate axon death genes, thereby providing novel potential drug targets for therapeutic intervention to prevent axonal and synaptic loss

    PrFeO3 Photocathodes Prepared Through Spray Pyrolysis

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    Perovskite oxides are receiving wide interest for photocatalytic and photoelectrochemical devices, owing to their suitable band gaps for solar light absorption and stability in aqueous applications. Herein, we assess the activity of PrFeO3 photocathodes prepared by using spray pyrolysis and calcination temperatures between 500 and 700 °C. Scanning electron microscopy shows corrugated films of high surface coverage on the conductive glass substrate. The electrochemically active surface area shows slight decreases with temperature increases from 500 to 600 and 700 °C. However, transient photocurrent responses and impedance spectroscopy data showed that films calcined at higher temperatures reduced the probabilities of recombination due to trap states, resulting in faster rates of charge extraction. In this trade‐off, a calcination temperature of 600 °C provided a maximum photocurrent of ‐130±4 μA cm−2 at +0.43 VRHE under simulated sunlight, with an incident photon‐to‐current conversion efficiency of 6.6 % at +0.61 VRHE and 350 nm and an onset potential of +1.4 VRHE for cathodic photocurrent

    Diazoxide-responsive hyperinsulinemic hypoglycemia caused by HNF4A gene mutations

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    Objective: The phenotype associated with heterozygous HNF4A gene mutations has recently been extended to include diazoxide responsive neonatal hypoglycemia in addition to maturity-onset diabetes of the young (MODY). To date, mutation screening has been limited to patients with a family history consistent with MODY. In this study, we investigated the prevalence of HNF4A mutations in a large cohort of patients with diazoxide responsive hyperinsulinemic hypoglycemia (HH). Subjects and methods: We sequenced the ABCC8, KCNJ11, GCK, GLUD1, and/or HNF4A genes in 220 patients with HH responsive to diazoxide. The order of genetic testing was dependent upon the clinical phenotype. Results: A genetic diagnosis was possible for 59/220 (27%) patients. KATP channel mutations were most common (15%) followed by GLUD1 mutations causing hyperinsulinism with hyperammonemia (5.9%), and HNF4A mutations (5%). Seven of the 11 probands with a heterozygous HNF4A mutation did not have a parent affected with diabetes, and four de novo mutations were confirmed. These patients were diagnosed with HI within the first week of life (median age 1 day), and they had increased birth weight (median +2.4 SDS). The duration of diazoxide treatment ranged from 3 months to ongoing at 8 years. Conclusions: In this large series, HNF4A mutations are the third most common cause of diazoxide responsive HH. We recommend that HNF4A sequencing is considered in all patients with diazoxide responsive HH diagnosed in the first week of life irrespective of a family history of diabetes, once KATP channel mutations have been excluded
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