Why punish hate?

An excerpt from chapter 7 of Professor Frederick M. Lawrence’s book Punishing hate: bias crimes under American law, considering the often controversial debate over the treatment in law of crimes motivated by racial hatred and the wider issue of punishment theory. Article by Professor Frederick M. Lawrence (Boston University, USA). Published in Amicus Curiae - Journal of the Institute of Advanced Legal Studies and its Society for Advanced Legal Studies. The Journal is produced by the Society for Advanced Legal Studies at the Institute of Advanced Legal Studies, University of London

Training response inhibition to food is associated with weight loss and reduced energy intake (article)

AcceptedNatalia S Lawrence University of Exeter Psychology Exeter Devon EX4 4QG United KingdomAccompanying dataset available at: http://hdl.handle.net/10871/17621Note to users: Uncorrected proofs are Articles in Press that have been copy edited and formatted, but have not been finalized yet. They still need to be proof-read and corrected by the author(s) and the text could still change before final publication. Although uncorrected proofs do not have all bibliographic details available yet, they can already be cited using the year of online publication and the DOI, as follows: author(s), article title, Publication (year), DOI. Please consult the journal's reference style for the exact appearance of these elements, abbreviation of journal names and use of punctuation. When the final article is assigned to an volumes/issues of the Publication, the Article in Press version will be removed and the final version will appear in the associated published volumes/issues of the Publication. The date the article was first made available online will be carried over.The majority of adults in the UK and US are overweight or obese due to multiple factors including excess energy intake. Training people to inhibit simple motor responses (key presses) to high-energy density food pictures reduces intake in laboratory studies. We examined whether online response inhibition training reduced real-world food consumption and weight in a community sample of adults who were predominantly overweight or obese (N = 83). Participants were allocated in a randomised, double-blind design to receive four 10-minute sessions of either active or control go/no-go training in which either high-energy density snack foods (active) or non-food stimuli (control) were associated with no-go signals. Participants’ weight, energy intake (calculated from 24-hour food diaries), daily snacking frequency and subjective food evaluations were measured for one week pre- and post-intervention. Participants also provided self-reported weight and monthly snacking frequency at pre-intervention screening, and one month and six months after completing the study. Participants in the active relative to control condition showed significant weight loss, reductions in daily energy intake and a reduction in rated liking of high-energy density (no-go) foods from the pre- to post-intervention week. There were no changes in self-reported daily snacking frequency. At longer-term follow-up, the active group showed significant reductions in self-reported weight at six months, whilst both groups reported significantly less snacking at one- and six-months. Excellent rates of adherence (97%) and positive feedback about the training suggest that this intervention is acceptable and has the potential to improve public health by reducing energy intake and overweight.National Institute for Health and Research Exeter Clinical Research FacilityWellcome TrustEuropean Research Counci

Understanding and optimising the transfection of lipopolyplexes formulated in saline: the effects of peptide and serum

Lipopolyplexes (LPDs) are of considerable interest for use as gene delivery vehicles. Here LPDs have been prepared from cationic vesicles (composed of a 1 : 1 molar ratio of DOTMA with the neutral helper lipid, DOPE), singly branched cationic peptides and plasmid DNA. All peptides contained a linker sequence (cleaved by endosomal furin) attached to a targeting sequence selected to bind human airway epithelial cells and mediate gene delivery. The current study investigates the effects of novel Arg-containing cationic peptide sequences on the biophysical and transfection properties of LPDs. Mixed His/Arg cationic peptides were of particular interest, as these sequences have not been previously used in LPD formulations. Lengthening the number of cationic residues in a homopolymer from 6 to 12 in each branch reduced transfection using LPDs, most likely due to increased DNA compaction hindering the release of pDNA within the target cell. Furthermore, LPDs containing mixed Arg-containing peptides, particularly an alternating Arg/His sequence exhibited an increase in transfection, probably because of their optimal ability to complex and subsequently release pDNA. To confer stability in serum, LPDs were prepared in 0.12 M sodium chloride solution (as opposed to the more commonly used water) yielding multilamellar LPDs with very high levels of size reproducibility and DNA protection, especially when compared to the (unilamellar) LPDs formed in water. Significantly for the clinical applications of the LPDs, those prepared in the presence of sodium chloride retained high levels of transfection in the presence of media supplemented with fetal bovine serum. This work therefore represents a significant advance for the optimisation of LPD formulation for gene delivery, under physiologically relevant conditions, in vivo

Overview of the spectrometer optical fiber feed for the Habitable-zone Planet Finder

The Habitable-zone Planet Finder (HPF) is a highly stabilized fiber fed precision radial velocity (RV) spectrograph working in the Near Infrared (NIR): 810 - 1280 nm . In this paper we present an overview of the preparation of the optical fibers for HPF. The entire fiber train from the telescope focus down to the cryostat is detailed. We also discuss the fiber polishing, splicing and its integration into the instrument using a fused silica puck. HPF was designed to be able to operate in two modes, High Resolution (HR- the only mode mode currently commissioned) and High Efficiency (HE). We discuss these fiber heads and the procedure we adopted to attach the slit on to the HR fibers.Comment: Presented at 2018 SPIE Astronomical Telescopes + Instrumentation, Austin, Texas, USA. 18 pages, 25 figures, and 2 table

Centerscope

Centerscope, formerly Scope, was published by the Boston University Medical Center "to communicate the concern of the Medical Center for the development and maintenance of improved health care in contemporary society.

Significance Testing Of Archeological Sites 41SR242, The Cornelio Alvarez SR. Site, Starr County, Texas

The Texas Department of Transportation (TxDOT), conducted National Register of Historic Places (NRHP) eligibility testing of the Cornelio Alvarez Sr. site (41SR242) as part of the State Loop (SL) 195 project (Project) (CSJ: 3632-01-001) in Starr County, Texas. Subsequent to the field investigations, SWCA Environmental Consultants (SWCA) conducted artifact analysis, reporting, and curation preparation for the multi-component historic and prehistoric site. Investigations were conducted in compliance with Section 106 of the National Historic Preservation Act (54 United State Code 30601) and the Antiquities Code of Texas (9 Natural Resources Code). The investigations assessed the site’s eligibility for listing on the NRHP (36 Code of Federal Regulations 60.4) and for designation as a State Antiquities Landmark (SAL; 13 Texas Administrative Code 26.8, 26.12). Christopher W. Ringstaff served as Principal Investigator under Texas Antiquities Permit Number 7912. TxDOT conducted the field investigations were from February 20–24, 2017, and April 10–14, 2017. Site 41SR242 is primarily a Middle to Late Archaic site with lesser Late Prehistoric and perhaps earlier components. The open occupational site is located on an upland margin landform in a tributary valley a few miles from the Rio Grande. The investigations revealed material assemblages consisting of diffusely scattered burned rock, debitage, and lithic tools, which were predominantly recovered from a 30- to 50- cm-thick stratum of mixed artifacts. However, a few concentrations of artifacts were identified, and each location yielded isolated intact features. Formation and post-depositional processes are generally not conducive to preservation of intact archeological surfaces, patterns, or site structure. Although the overall site lacks integrity and potential data yield, isolated discrete behavioral loci are present. Therefore, site 41SR242 is recommended as eligible for the NRHP and as an SAL. This recommendation pertains to the portions of the site within the APE. The site extends beyond the APE, and the areas outside of the APE have not been evaluated

Significance Testing of Archeological Site 41SR242, The Cornelio Alvarez Sr. Site, Starr County, Texas

The Texas Department of Transportation (TxDOT), conducted National Register of Historic Places (NRHP) eligibility testing of the Cornelio Alvarez Sr. site (41SR242) as part of the State Loop (SL) 195 project (Project) (CSJ: 3632-01-001) in Starr County, Texas. Subsequent to the field investigations, SWCA Environmental Consultants (SWCA) conducted artifact analysis, reporting, and curation preparation for the multi-component historic and prehistoric site. Investigations were conducted in compliance with Section 106 of the National Historic Preservation Act (54 United State Code 30601) and the Antiquities Code of Texas (9 Natural Resources Code). The investigations assessed the site’s eligibility for listing on the NRHP (36 Code of Federal Regulations 60.4) and for designation as a State Antiquities Landmark (SAL; 13 Texas Administrative Code 26.8, 26.12). Christopher W. Ringstaff served as Principal Investigator under Texas Antiquities Permit Number 7912. TxDOT conducted the field investigations were from February 20–24, 2017, and April 10–14, 2017. Site 41SR242 is primarily a Middle to Late Archaic site with lesser Late Prehistoric and perhaps earlier components. The open occupational site is located on an upland margin landform in a tributary valley a few miles from the Rio Grande. The investigations revealed material assemblages consisting of diffusely scattered burned rock, debitage, and lithic tools, which were predominantly recovered from a 30- to 50-cm-thick stratum of mixed artifacts. However, a few concentrations of artifacts were identified, and each location yielded isolated intact features. Formation and post-depositional processes are generally not conducive to preservation of intact archeological surfaces, patterns, or site structure. Although the overall site lacks integrity and potential data yield, isolated discrete behavioral loci are present. Therefore, site 41SR242 is recommended as eligible for the NRHP and as an SAL. This recommendation pertains to the portions of the site within the APE. The site extends beyond the APE, and the areas outside of the APE have not been evaluated

Heavy Fermion Behavior, Crystalline Electric Field Effects, and Weak Ferromagnetism in SmOs_{4}Sb_{12}

The filled skutterudite compound SmOs_{4}Sb_{12} was prepared in single crystal form and characterized. The SmOs_{4}Sb_{12} crystals have the LaFe_{4}P_{12}-type structure with lattice parameter a = 9.3085 Angstroms. Specific heat measurements indicate a large electronic specific heat coefficient of ~880 mJ/mol K^{2}, from which an enhanced effective mass m^{*} ~ 170 m_{e} is estimated. The specific heat data also suggest crystalline electric field (CEF) splitting of the Sm^{3+} J = 5/2 multiplet into a Gamma_{7} doublet ground state and a Gamma_{8} quartet excited state separated by 37 K. Electrical resistivity rho(T) measurements reveal a decrease in rho(T) below ~50 K that is consistent with CEF splitting of ~33 K between a Gamma_(7) doublet ground state and Gamma_{8} quartet excited state. Specific heat and magnetic susceptibility measurements display a possible weak ferromagnetic transition at ~2.6 K, which could be an intrinsic property of SmOs_4Sb_{12} or possibly due to an unknown impurity phase.Comment: 24 pages, 11 Postscript figures, to be published in Physical Review