S18RS SGR No. 1 (TOPS)

A RESOLUTION To strongly urge the Louisiana State Legislature to FULLY fund the Taylor Opportunity Program for Students (TOPS) during the 2018 Legislative sessio

Toward Housing Stability: Exiting Homelessness as an Emerging Adult

This paper explores the lives of formerly homeless young people as they transitioned towards housing stability. The study employed a longitudinal design involving 51 street youth in Halifax, N.S. (n = 21) and Toronto, ON (n = 30). This paper sheds light upon the pathways through which young people transitioned away from homelessness using the developmental lens of emerging adulthood: a stage involving numerous developmental struggles (identity, instability, self-focus, feeling in-between) but also an age filled with hope and possibilities. There are numerous interrelated factors at play that allow participants to regain a sense of citizenship with mainstream society. While housing in itself did not shape these young people\u27s sense of stability, it influenced feelings of health, happiness and security. Yet, our participants, as a particular segment of the youth population who have transitioned out of basic homelessness, continue to describe their current lives in terms of fragility and instability. For most, opportunity for experimentation and identity exploration was often curtailed by processes outside of their control and struggles with the consequences of profound disempowerment —past trauma with family and/or current struggles with public sector structures and services. As a result, many felt abandoned and stigmatized by the very resources whose mission it is to assist

The effect of head and neck per-cooling on neuromuscular fatigue following exercise in the heat

The effect of localised head and neck per-cooling on central and peripheral fatigue during high thermal strain was investigated. Fourteen participants cycled for 60 min at 50% peak oxygen uptake on 3 occasions: thermoneutral control (CON; 18 °C), hot (HOT; 35 °C), and HOT with head and neck cooling (HOTcooling). Maximal voluntary force (MVF) and central activation ratio (CAR) of the knee extensors were measured every 30 s during a sustained maximal voluntary contraction (MVC). Triplet peak force was measured following cycling, before and after the MVC. Rectal temperatures were higher in HOTcooling (39.2 ± 0.6 °C) and HOT (39.3 ± 0.5 °C) than CON (38.1 ± 0.3 °C; P < 0.05). Head and neck thermal sensation was similar in HOTcooling (4.2 ± 1.4) and CON (4.4 ± 0.9; P > 0.05) but lower than HOT (5.9 ± 1.5; P < 0.05). MVF and CAR were lower in HOT than CON throughout the MVC (P < 0.05). MVF and CAR were also lower in HOTcooling than CON at 5, 60, and 120 s, but similar at 30 and 90 s into the MVC (P > 0.05). Furthermore, they were greater in HOTcooling than HOT at 30 s, whilst triplet peak force was preserved in HOT after MVC. These results provide evidence that central fatigue following exercise in the heat is partially attenuated with head and neck cooling, which may be at the expense of greater peripheral fatigue

Structural Conservation and E2F Binding Specificity within the Retinoblastoma Pocket Protein Family

The human pocket proteins retinoblastoma (Rb), p107, and p130 are critical negative regulators of the cell cycle and contribute to tumor suppression. While strong structural conservation within the pocket protein family provides for some functional redundancy, important differences have been observed and may underlie the reason that Rb is a uniquely potent tumor suppressor. It has been proposed that distinct pocket protein activities are mediated by their different E2F transcription factor binding partners. In humans, Rb binds E2F1–E2F5, whereas p107 and p130 almost exclusively associate with E2F4 and E2F5. To identify the molecular determinants of this specificity, we compared the crystal structures of Rb and p107 pocket domains and identified several key residues that contribute to E2F selectivity in the pocket family. Mutation of these residues in p107 to match the analogous residue in Rb results in an increase in affinity for E2F1 and E2F2 and an increase in the ability of p107 to inhibit E2F2 transactivation. Additionally, we investigated how phosphorylation by Cyclin-dependent kinase on distinct residues regulates p107 affinity for the E2F4 transactivation domain. We found that phosphorylation of residues S650 and S975 weakens the E2F4 transactivation domain binding. Our data reveal molecular features of pocket proteins that are responsible for their similarities and differences in function and regulation