Swimming against the tide: a study of a neighbourhood trying to rediscover its ‘reason for being’– the case of South Bank, Redcar and Cleveland

Many of the programmes and initiatives to regenerate deprived neighbourhoods appear to have had limited lasting impact. It has been argued that one reason for this is that we still have little real understanding of the nature and scale of the problems some communities face (Bernt, 2009). This paper attempts to add to our knowledge through close study of an area with multiple problems and a history of failed regeneration attempts. An in-depth case study undertaken to explore the current situation and future prospects of South Bank, a small neighbourhood in the North East of England, highlights transferable knowledge which may be applied to other regeneration areas. The analysis considers the nature and consequences of industrial decline; entrenched deprivation; the stigmatization of communities; the value of community consultation and the potential impact of retail-led regeneration. We question whether negative stigma attached to places can be changed and we ask what the future may hold for deprived communities now that public sector funding has largely dried up, and we consider an alternative approach: the potential impacts of private sector retail-led regeneration in the absence of public sector funding

'It'll get worse before it gets better': Local experiences of living in a regeneration area

The negative consequences of living in deprived neighbourhoods for residents’ quality of life are well documented. Area-based regeneration initiatives are invariably concerned with improving local quality of life over the long term. The process of regeneration, however, can itself directly result in immediate and potentially lasting negative effects for local communities. This paper discusses some of the ways in which living in an area undergoing regeneration can adversely affect inhabitants’ quality of life, including problems associated with voids, relocation, demolitions, environmental quality, complexity, funding issues, uncertainty, frustration, fear for the future and consultation fatigue. A case study approach draws examples from a deprived neighbourhood in the North East of England. The conclusion discusses some of the possible implications for future regeneration policy, including: the importance of ongoing communication between professionals and communities; the need to value local people’s experience, judgement and the contribution they can make to local decision-making processes; recognition that successful regeneration can take many years; and the implications of current UK government policy

Genomic function during the lampbrush chromosome stage of amphibian oogenesis

Throughout its lengthy developmental history the disposition of the genetic material in the amphibian oocyte nucleus differs from that in other cell types. The chromosomes in the oocyte nucleus, arrested for the whole of oogenesis at the prophase of the first meiotic division, are known to contain at least the tetraploid amount of DNA.(1,2) Oogenesis in amphibia requires months or even years to complete, depending on the species

ICIS 2017 Panel Report: Break Your Shackles! Emancipating Information Systems from the Tyranny of Peer Review

The paper presents the report of a panel that debated the review process in the information systems (IS) discipline at ICIS 2017 in Seoul, Korea. The panel asked the fundamental question of whether we need to rethink the way we review papers in the discipline. The panelists partnered with the audience to explore some reviewing limitations in IS today and the ways that reviewing in the discipline might change to address some of its difficulties. We first report key concerns with modern reviewing. We then present arguments for and against three proposals (i.e., paying for reviews, mandatory reviews, and open reviews) and a panel audience vote on the issues. We neither advocate for nor condemn these solutions but rather use them to illustrate what we believe represent the core underlying issues with reviewing in the IS discipline. Specifically, we believe the key stumbling blocks to effectively improving our review process include 1) a lack of empirical data on actual practice, 2) a lack of clear goals, and 3) an ignorance of the possible solutions to the review dilemma that the wider literature articulates

927-37 Is Coronary Revascularization Complete Therapy for Secondary Prevention of Ischemic Cardiac Arrest?

Coronary revascularization has been suggested assole therapy for secondary prevention of sudden cardiac arrest associated with ischemia. Among 412 consecutive patients receiving an implantable defibrillator (ICD), 23 (6%) were identified as: sudden cardiac arrest survivors, noninducible with programmed stimulation, unstable angina or ischemia on a functional study, and underwent successful coronary revascularization. In follow-up, 10 (43%) of the 23 patients received ICD shocks (8±8 per patient, range: 1–22) shocks) and 9/10 had syncope/presyncope associated with at least one ICD discharge.Clinical Characteristics:ICD firings (n=10)*No ICD firings (n=13)*Follow-up (months)39±1331±21Age (years)63±763±12Male gender89Mean left ventricular ejection fraction (%)36±1040±14Previous history of a myocardial infarction1010Presence of a left ventricular aneurysm41Q-wave infarction pattern on electrocardiogram75Sudden cardiac arrest presenting with exertion, angina, or CPK elevation88Mean number of vessels with coronary disease2.2±0.823±0.9Mean severity of coronary stenosis (%)87±1888±16Coronary revascularization considered complete710β-blocker therapy55Antiarrhythmic therapy812*p value>0.05No clinical characteristic was statistically different between patients with and without ICD shocks. In conclusion, coronary revascularization alone may be inadequate therapy for survivors of sudden cardiac arrest associated with ischemia who are noninducible with programmed stimulation, and clinical variables cannot predict which patients are likely to experience recurrent malignant ventricular arrhythmias. Therefore, ICD therapy should be considered in these patients

927-37 Is Coronary Revascularization Complete Therapy for Secondary Prevention of Ischemic Cardiac Arrest?

Coronary revascularization has been suggested assole therapy for secondary prevention of sudden cardiac arrest associated with ischemia. Among 412 consecutive patients receiving an implantable defibrillator (ICD), 23 (6%) were identified as: sudden cardiac arrest survivors, noninducible with programmed stimulation, unstable angina or ischemia on a functional study, and underwent successful coronary revascularization. In follow-up, 10 (43%) of the 23 patients received ICD shocks (8±8 per patient, range: 1–22) shocks) and 9/10 had syncope/presyncope associated with at least one ICD discharge.Clinical Characteristics:ICD firings (n=10)*No ICD firings (n=13)*Follow-up (months)39±1331±21Age (years)63±763±12Male gender89Mean left ventricular ejection fraction (%)36±1040±14Previous history of a myocardial infarction1010Presence of a left ventricular aneurysm41Q-wave infarction pattern on electrocardiogram75Sudden cardiac arrest presenting with exertion, angina, or CPK elevation88Mean number of vessels with coronary disease2.2±0.823±0.9Mean severity of coronary stenosis (%)87±1888±16Coronary revascularization considered complete710β-blocker therapy55Antiarrhythmic therapy812*p value>0.05No clinical characteristic was statistically different between patients with and without ICD shocks. In conclusion, coronary revascularization alone may be inadequate therapy for survivors of sudden cardiac arrest associated with ischemia who are noninducible with programmed stimulation, and clinical variables cannot predict which patients are likely to experience recurrent malignant ventricular arrhythmias. Therefore, ICD therapy should be considered in these patients

On the side of the angels: community involvement in the governance of neighbourhood renewal.

This article draws upon the authors’ experiences of community-led regeneration developed while members of the National Evaluation Team for the NDC Programme. The article continues the focus on urban regeneration adopted in a range of outputs from two of the authors over the last decade. In assessing how the term community has been defined by policy-makers and the challenges involved in empowering communities, the output was aimed at both academic and user communities. For its direct relevance to communities involved in regeneration, the article was awarded the 2006 Sam Aaronovitch Prize, awarded annually by the journal Local Economy

On the Power and Weakness of Rational Expectations: Logical Fallacies, Periodic Bubbles and Business Cycles

A popular interpretation of the Rational Expectations/Efficient Markets hypothesis states that, if the hypothesis holds, then market valuations must follow a random walk. This postulate has frequently been criticized on the basis of empirical evidence. Yet the assertion itself incurs what we could call 'fallacy of probability diffusion symmetry': although market efficiency does indeed imply that the mean (i.e. expected) path must be a random walk, if the probability diffusion process is asymmetric then the observed path will most closely resemble not the mean but the median, which does not necessarily follow a random walk. To illustrate the implications, this paper develops an efficient markets model where the median path of Tobin's q ratio displays regular cycles of bubbles and crashes reflecting an agency problem between investors and producers. The model is tested against US market data, with results suggesting that such a regular cycle does indeed exist and is statistically significant. The aggregate production function in Gracia (Uncertainty and Capacity Constraints: Reconsidering the Aggregate Production Function, 2011) is then put forward to show how financial fluctuations can drive the business cycle by periodically impacting aggregate productivity and, as a consequence, GDP growth