Igby Goes Down

This is a review of Igby Goes Down (2002)

Jodhaa Akbar

This is a review of Jodhaa Akbar (2008)

Sweet Sixteen

This is a review of Sweet Sixteen (2002)

Changing lexicons : a study of young adult programming at the Denver Art Museum

A decrease in arts participation among Generation Y young adults demonstrates a need for museum educators to increase programming efforts with this audience. By reaching out to young adults, educators can secure museums’ relevance in society while inspiring lifelong learning in what will be America’s largest generation. Moreover, due to their learning preferences young adults present an opportunity for educators to investigate participatory and digital engagement programming. This explanatory case study draws from current research on Generation Y and recent trends in museum programming particularly related to the young adult audience. It explores the approach of educators at the Denver Art Museum (DAM) to developing young adult programs. I conducted interviews with DAM staff members and program evaluators and examined multiple documents related to the development of these programs. Based on my data, I identified five key features of the Denver Art Museum’s approach and assessed their suitability for transferring to other museums.Art Educatio

A closer look at ARSA activity in a patient with metachromatic leukodystrophy.

Metachromatic leukodystrophy (MLD) is an autosomal recessive lysosomal storage disease mainly caused by a deficiency of arylsulfatase A activity. The typical clinical course of patients with the late infantile form includes a regression in motor skills with progression to dysphagia, seizures, hypotonia and death. We present a case of a 4-year-old female with rapidly progressive developmental regression with loss of motor milestones, spasticity and dysphagia. MRI showed volume loss and markedly abnormal deep white matter. Enzymatic testing in one laboratory showed arylsulfatase A activity in their normal range. However, extraction of urine showed a large increase in sulfatide excretion in a second laboratory. Measurement of arylsulfatase A in that laboratory showed a partial decrease in arylsulfatase A activity measured under typical conditions (about 37% of the normal mean). When the concentration of substrate in the assay was lowered to one quarter of that normally used, this individual had activity \u3c10% of controls. The patient was found to be homozygous for an unusual missense mutation in the arylsulfatase A gene confirming the diagnosis of MLD. This case illustrates the importance of careful biochemical and molecular testing for MLD if there is suspicion of this diagnosis

Safe Spring Break [brochure and streaming video]

Many college students use spring break as a time to unwind and get away from their classes and responsibilities, but unfortunately many also leave their common sense behind. Our video will show students how to incorporate safe practices into their vacations. We will go into detail about safe alcohol consumption, consent education, and basic emergency procedures. Our goal is that students will have the information they need to take care of themselves and their friends. We are using the below article as our theatrical basis, as well as information from the Harm Reduction Alliance, a coalition of fraternity and sorority headquarters who have teamed up to produce risk-reduction education materials

Trends in Alaska's Health-Care Spending

All Americans spend a lot to get health care—but Alaskans spend the most per resident, face the highest insurance premiums, and have seen overall spending grow much faster. Here we highlight some trends in Alaska’s health-care spending since the 1990s, based on existing publicly available data that allow us to compare changes in Alaska and nationwide. A chart book with much more detail is available on ISER’s website. We hope this broad information on trends in health-care spending will help Alaskans better understand what happened, consider possible reasons why, and think about potential ways to change the upward spiral.Harold E. Pomeroy Public Policy Research Endowment University of Alaska Foundatio

Implementing SBIRT in Primary Care: A Study of Three Mat-Su Borough Health Care Practices

Despite decades of research evidence that SBIRT is effective for addressing unhealthy patterns of drinking and reducing binge drinking, its adoption within healthcare practices continues to be slow. Providers have identified numerous reasons for not routinely screening and intervening on alcohol, including limited time, training, and resources for patients requiring treatment; lack of confidence in their ability to help patients reduce their drinking; inadequate reimbursement for SBIRT services, and worry about stigmatizing patients

Integrating Life Cycle and Impact Assessments to Map Food's Cumulative Environmental Footprint

Producing food exerts pressures on the environment. Understanding the location and magnitude of food production is key to reducing the impacts of these pressures on nature and people. In this Perspective, Kuempel et al. outline an approach for integrating life cycle assessment and cumulative impact mapping data and methodologies to map the cumulative environmental pressure of food systems. The approach enables quantification of current and potential future environmental pressures, which are needed to reduce the net impact of feeding humanity. © 2020 The AuthorsFeeding a growing, increasingly affluent population while limiting environmental pressures of food production is a central challenge for society. Understanding the location and magnitude of food production is key to addressing this challenge because pressures vary substantially across food production types. Applying data and models from life cycle assessment with the methodologies for mapping cumulative environmental impacts of human activities (hereafter cumulative impact mapping) provides a powerful approach to spatially map the cumulative environmental pressure of food production in a way that is consistent and comprehensive across food types. However, these methodologies have yet to be combined. By synthesizing life cycle assessment and cumulative impact mapping methodologies, we provide guidance for comprehensively and cumulatively mapping the environmental pressures (e.g., greenhouse gas emissions, spatial occupancy, and freshwater use) associated with food production systems. This spatial approach enables quantification of current and potential future environmental pressures, which is needed for decision makers to create more sustainable food policies and practices. © 2020 The Author

The Tryptophan Hydroxylase Inhibitor LX1031 Shows Clinical Benefit in Patients With Nonconstipating Irritable Bowel Syndrome

Serotonin (5-hydroxytryptamine [5-HT]) has an important role in gastrointestinal function. LX1031 is an oral, locally acting, small molecule inhibitor of tryptophan hydroxylase (TPH). Local inhibition of TPH in the gastrointestinal tract might reduce mucosal production of serotonin (5-HT) and be used to treat patients with nonconstipating irritable bowel syndrome (IBS)